Therapeutic potential of palm oil vitamin E-derived tocotrienols in inflammation and chronic diseases: Evidence from preclinical and clinical studies

Zainal, Zaida; Khaza’ai, Huzwah; Radhakrishnan, Ammu Kutty; Chang, Sui Kiat

doi:10.1016/j.foodres.2022.111175

Cited by 31 publications

(18 citation statements)

References 253 publications

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“…Chronic inflammation has manifested as chronic kidney disease, rheumatoid arthritis, CVD, diabetes, cancers, neurodegeneration, metabolic syndrome, and liver disease. 185 Tocotrienols have successfully curbed inflammation by a variety of physiological mechanisms of which the downregulation of the gene expression of proinflammatory cytokines and the repression of inflammatory biomarkers are more common strategies. 186 The prominent biomarkers that are suppressed with tocotrienols include IL-6, TNF-a, MDA, and C-reactive protein although most results have been inconsistent.…”

Section: Anti-inflammatory Behavior Of Tocotrienolmentioning

confidence: 99%

“…Importantly, both these immune aberrant mechanisms are attenuated by tocotrienol therapy. Chronic inflammation has manifested as chronic kidney disease, rheumatoid arthritis, CVD, diabetes, cancers, neurodegeneration, metabolic syndrome, and liver disease 185 . Tocotrienols have successfully curbed inflammation by a variety of physiological mechanisms of which the downregulation of the gene expression of pro‐inflammatory cytokines and the repression of inflammatory biomarkers are more common strategies 186 .…”

Section: Antioxidant and Anti‐inflammatory Activities Of Tocotrienolmentioning

confidence: 99%

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Revisiting the therapeutic potential of tocotrienol

2022

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The therapeutic potential of the tocotrienol group stems from its nutraceutical properties as a dietary supplement. It is largely considered to be safe when consumed at low doses for attenuating pathophysiology as shown by animal models, in vitro assays, and ongoing human trials. Medical researchers and the allied sciences have experimented with tocotrienols for many decades, but its therapeutic potential was limited to adjuvant or concurrent treatment regimens. Recent studies have focused on targeted drug delivery by enhancing the bioavailability through carriers, self‐sustained emulsions, nanoparticles, and ethosomes. Epigenetic modulation and computer remodeling are other means that will help increase chemosensitivity. This review will focus on the systemic intracellular anti‐cancer, antioxidant, and anti‐inflammatory mechanisms that are stimulated and/or regulated by tocotrienols while highlighting its potent therapeutic properties in a diverse group of clinical diseases.

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Section: Anti-inflammatory Behavior Of Tocotrienolmentioning

confidence: 99%

Section: Antioxidant and Anti‐inflammatory Activities Of Tocotrienolmentioning

confidence: 99%

Revisiting the therapeutic potential of tocotrienol

2022

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“…Vitamin E exerts its health benefits primarily through its antioxidant and anti-inflammatory properties ( 34 , 35 ). Both the α-tocopherol and γ-tocopherol can modulate mitochondrial oxidative metabolism to ameliorate Alzheimer’s disease ( 36 ).…”

Section: Discussionmentioning

confidence: 99%

Association of multiple serum minerals and vitamins with metabolic dysfunction-associated fatty liver disease in US adults: National Health and Nutrition Examination Survey 2017–2018

Guo,

2024

Front. Nutr.

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BackgroundDespite the rapid increase in the global prevalence of Metabolic Dysfunction-Associated Fatty Liver Disease (MAFLD), there are no approved therapeutic drugs for MAFLD yet. Nutrient supplementation might mitigate the risk of MAFLD. It is more typical for individuals to consume multiple nutrients simultaneously. However, the studies exploring the combined effects of multiple nutrients on MAFLD are limited. This study aimed to investigate the relationship between both individual nutrients and their combined influence on the risk of MAFLD.MethodsData were obtained from National Health and Nutrition Examination Survey (NHANES), and 18 types of nutrients were considered in this study. Logistic regression analysis was performed to evaluate the correlation between single nutrients and the risk of MAFLD. The Least Absolute Shrinkage and Selection Operator (LASSO) regression analysis was performed to pinpoint the most relevant nutrient associated with the risk of MAFLD. Subsequently, both Weighted Quantile Sum (WQS) regression and Quantile g-computation (Qgcomp) were used to assess the combined effects of multiple nutrients on the risk of MAFLD.ResultsA total of 3,069 participants were included in this study. LASSO regression analysis showed that Se, α-tocopherol, and γ-tocopherol exhibited a positive association with the risk of MAFLD. In contrast, the serum levels of Co, P, α-cryptoxanthin, LZ, and trans-β-carotene were inversely associated with the prevalence of MAFLD. When Se and two types of vitamin E were excluded, the WQS index showed a significant inverse relationship between the remaining 15 nutrients and the risk of MAFLD; α-cryptoxanthin showed the most substantial contribution. Similarly, Qgcomp suggested that the combined effects of these 15 nutrients were associated with a lower risk of MAFLD, with α-cryptoxanthin possessing the most significant negative weights.ConclusionThis study suggested that the complex nutrients with either a low proportion of Se, α-tocopherol, and γ-tocopherol or without them should be recommended for patients with MAFLD to reduce its risk.

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“…The cumulative anti-osteoporosis benefits of palm oil tocotrienols include a reduction in bone loss in postmenopausal female rats, improved bone strength and fracture resistance, and increased bone density. Palm oil tocotrienols also preserved the levels of cytokines involved in osteoclast differentiation and improved the cellular and dynamic properties of rat bone [ 57 ]. In addition, tocotrienols also strengthen young adults’ peak bone mass, which could be an indication of preventative effect of tocotrienols [ 58 ].…”

Section: Improving Tocotrienols’ Bioavailability For the Future Of An...mentioning

confidence: 99%

Ameliorative Effect of Tocotrienols on Perimenopausal-Associated Osteoporosis—A Review

et al. 2022

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Osteoporosis, or bone loss, is a disease that affects many women globally. As life expectancy increases, the risk of osteoporosis in women also increases, too, and this will create a burden on the healthcare and economic sectors of a country. Osteoporosis was once thought to be a disease that would occur only after menopause. However, many studies have shown that osteoporosis may develop even in the perimenopausal stage. Due to the erratic levels of estrogen and progesterone during the perimenopausal stage, studies suggest that women are exposed to the risk of developing osteoporosis even at this stage. The erratic hormonal changes result in the production of proinflammatory mediators and cause oxidative stress, which leads to the progressive loss of bone-building activities. Tocotrienols, members of vitamin E, have many health-promoting properties. Due to their powerful anti-oxidative and anti-inflammatory properties, tocotrienols have shown positive anti-osteoporotic properties in post-menopausal studies. Hence, we propose here that tocotrienols could also possibly alleviate perimenopausal osteoporosis by discussing in this review the connection between inflammatory mediators produced during perimenopause and the risk of osteoporosis. Tocotrienols could potentially be an anti-osteoporotic agent, but due to their low bioavailability, they have not been as effective as they could be. Several approaches have been evaluated to overcome this issue, as presented in this review. As the anti-osteoporotic effects of tocotrienols were mostly studied in post-menopausal models, we hope that this review could pave the way for more research to be done to evaluate their effect on peri-menopausal models so as to reduce the risk of osteoporosis from an earlier stage.

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Therapeutic potential of palm oil vitamin E-derived tocotrienols in inflammation and chronic diseases: Evidence from preclinical and clinical studies

Cited by 31 publications

References 253 publications

Revisiting the therapeutic potential of tocotrienol

Revisiting the therapeutic potential of tocotrienol

Association of multiple serum minerals and vitamins with metabolic dysfunction-associated fatty liver disease in US adults: National Health and Nutrition Examination Survey 2017–2018

Ameliorative Effect of Tocotrienols on Perimenopausal-Associated Osteoporosis—A Review

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