Therapeutic Potential of Plant Oxylipins

Abstract

For immobile plants, the main means of protection against adverse environmental factors is the biosynthesis of various secondary (specialized) metabolites. The extreme diversity and high biological activity of these metabolites determine the researchers’ interest in plants as a source of therapeutic agents. Oxylipins, oxygenated derivatives of fatty acids, are particularly promising in this regard. Plant oxylipins, which are characterized by a diversity of chemical structures, can exert protective and therapeutic properties in animal cells. While the therapeutic potential of some classes of plant oxylipins, such as jasmonates and acetylenic oxylipins, has been analyzed thoroughly, other oxylipins are barely studied in this regard. Here, we present a comprehensive overview of the therapeutic potential of all major classes of plant oxylipins, including derivatives of acetylenic fatty acids, jasmonates, six- and nine-carbon aldehydes, oxy-, epoxy-, and hydroxy-derivatives of fatty acids, as well as spontaneously formed phytoprostanes and phytofurans. The presented analysis will provide an impetus for further research investigating the beneficial properties of these secondary metabolites and bringing them closer to practical applications.

Comparison of the inedible parts of white and green asparagus based on metabolomics and network pharmacology

“…A few studies indicated that plant oxylipins showed anticancer, antitumor, antifungal, anti-inflammatory and immunomodulatory effects. 41 In this study, the key targets, such as PIK3CA, AKT1 and ESR1, were associated with multiple oxylipins. There are 10 oxylipins acting on the ESR1 target, 9 oxylipins acting on the AKT1 target and 6 oxylipins acting on the PIK3CA target.…”

Antioxidant and Cytotoxic Potential of Carlina vulgaris Extract and Bioactivity-Guided Isolation of Cytotoxic Components

“…A bioactivity-guided approach led to the isolation of three main constituents from the extract with potential cytotoxic effects on cells, namely pinellic acid (PA), traumatic acid (TA), and 9,10-dihydroxy-8-oxsooctadec-12-enic acid (MUA). The compounds belong to oxylipin family, which are products from the oxygenation of fatty acids accumulated in plants in response to stress conditions [ 20 , 21 ]. They exhibit interesting biological activities, including pro-/anti-inflammatory, antimicrobial, neuroprotective, and regulatory effects [ 22 , 23 ].…”

Traumatic acid inhibits ACSL4 associated lipid accumulation in adipocytes to attenuate high‐fat diet‐induced obesity

“…TA is an oxylipin biosynthesized in plants by non‐enzymatic oxidation of traumatin (12‐oxo‐trans‐10‐dodecanoic acid) 29 . Plant oxylipins, characterized by diverse chemical structures, are an important class of secondary metabolites that protect plants from adverse environmental factors and can exert protective and therapeutic effects in animal cells 30 . Hence, as a member of the oxylipins, TA is an essential medium of dialogue between plants and animals.…”

“…29 Plant oxylipins, characterized by diverse chemical structures, are an important class of secondary metabolites that protect plants from adverse environmental factors and can exert protective and therapeutic effects in animal cells. 30 Hence, as a member of the oxylipins, TA is an essential medium of dialogue between plants and animals. Furthermore, TA has recently been detected in the peripheral blood of sarcopenia subjects 31 and patients with inflammatory bowel disease, 32 illustrating that TA is also an endogenous metabolite.…”