Therapeutic Potential of Polyphenols in Parkinson’s Disease

Mythri, Rajeswara Babu; Harish, G.; Raghunath, Narayana Reddy; Bharath, M. M. Srinivas

doi:10.5772/20055

Towards New Therapies for Parkinson's Disease 2011

DOI: 10.5772/20055

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Therapeutic Potential of Polyphenols in Parkinson’s Disease

Rajeswara Babu Mythri¹,

G. Harish²,

Narayana Reddy Raghunath³

et al.

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2020

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References 258 publications

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“…Phenolic compounds are significant contributors in the fields of agrochemicals, [5] polymers, [6] pharmaceuticals, [7] natural antioxidants [8] such as flavonoids, phenolic acids, coumarins and lignans. These derivatives are witnessed to treat Anesthesia, [9] Parkinson's disease [10] and several life-threatening medical disorders. [11] During the past decades, a large number of reactions were devised to serve the synthesis of phenols.…”

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Amino‐Acid‐Mediated Aerobic Oxidation of Organoborons for the Synthesis of Phenolic Derivatives Using Single Electron Transfer

et al. 2020

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An efficient amino‐acid‐mediated ipso‐hydroxylation of arylboronic acids, aryl boronate esters and aryl trifluoroborates to aryl alcohols has been described. The current protocol was realized by using sub‐stoichiometric amount of l‐histidine in presence of triethylamine under aerobic conditions in DMF as solvent. This amino‐acid‐mediated process provides an alternative route for the hydroxylation of organoborons through in situ generation of hydrogen peroxide. The present protocol explores the synthetic utility of amino acids as organocatalysts for the preparation of aryl alcohols. It was observed that l‐histidine plays an important role for the conversion of aerial oxygen in to hydrogen peroxide via thermal excitation process followed by thermal degradation of Et3N. The developed approach holds good for a wide range of compounds with excellent yields and competent functional group tolerance.

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Amino‐Acid‐Mediated Aerobic Oxidation of Organoborons for the Synthesis of Phenolic Derivatives Using Single Electron Transfer

et al. 2020

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Therapeutic Potential of Polyphenols in Parkinson’s Disease

Cited by 1 publication

References 258 publications

Amino‐Acid‐Mediated Aerobic Oxidation of Organoborons for the Synthesis of Phenolic Derivatives Using Single Electron Transfer

Amino‐Acid‐Mediated Aerobic Oxidation of Organoborons for the Synthesis of Phenolic Derivatives Using Single Electron Transfer

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