Therapeutic Potential of Polyphenols-Loaded Polymeric Nanoparticles in Cardiovascular System

Pecháňová, Oľga; Dayar, Ezgi; Cebová, Martina

doi:10.3390/molecules25153322

Cited by 41 publications

(21 citation statements)

References 160 publications

(196 reference statements)

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“…A recent study has suggested that curcumin blocks LPA-induced MCP-1 expression via TGFBR1/ROCK signaling pathway [ 103 ].Additional studies are required to improve or add meaningful insights into our understanding of the mechanism(s) of action of curcumin against atherosclerosis, especially in the clinical setting. In addition, the development of novel drug delivery systems, such as the creation of curcumin nanomicelles [ 104 , 105 ], is critical for improving the oral bioavailability of curcumin which may contribute to its clinical efficacy [ 106 ].…”

Section: Discussionmentioning

confidence: 99%

Curcumin as a Natural Remedy for Atherosclerosis: A Pharmacological Review

Singh

Sharma

et al. 2021

Molecules

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Curcumin, a natural polyphenolic compound present in Curcuma longa L. rhizomes, shows potent antioxidant, anti-inflammatory, anti-cancer, and anti-atherosclerotic properties. Atherosclerosis is a comprehensive term for a series of degenerative and hyperplasic lesions such as thickening or sclerosis in large- and medium-sized arteries, causing decreased vascular-wall elasticity and lumen diameter. Atherosclerotic cerebro-cardiovascular disease has become a major concern for human health in recent years due to its clinical sequalae of strokes and heart attacks. Curcumin concoction treatment modulates several important signaling pathways related to cellular migration, proliferation, cholesterol homeostasis, inflammation, and gene transcription, among other relevant actions. Here, we provide an overview of curcumin in atherosclerosis prevention and disclose the underlying mechanisms of action of its anti-atherosclerotic effects.

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Section: Discussionmentioning

confidence: 99%

Curcumin as a Natural Remedy for Atherosclerosis: A Pharmacological Review

Singh

Sharma

et al. 2021

Molecules

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“…Additional studies are required to improve or add meaningful insights into our understandingof the mechanism of the action of curcumin against atherosclerosis in mice and human patients. In addition, the development of novel drug delivery systems, such as the creation of curcumin nanomicelles [84,85], is critical for improving curcumin oral bioavailability [86].…”

Section: Discussionmentioning

confidence: 99%

Curcumin as a Natural Remedy for Atherosclerosis: A Pharmacological Review

Singh¹,

Sharma²,

Xu³

et al. 2021

Preprint

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Curcumin, a hydrophobic bioactive constituent from Curcuma longa, has several health promoting properties including anti-atherosclerotic properties. Further, curcumin has blood glucose- and lipid-lowering properties, prophylactic, and therapeutic effects in other cardiometabolic diseases. Atherosclerosis is an umbrella term for a series of degenerative and hyperplasic lesions such as thickening or sclerosis in large and medium -sized artery walls that decrease vascular-wall elasticity and lumen diameter. The atherosclerotic cerebro-cardiovascular disease has become a major concern to human health in recent years. Considering the notable cardiovascular actions of curcumin, the present review summarizes the current status and future perspective of research on curcumin and its ability to prevent or treat atherosclerosis

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“…Quercetin-like plant compounds have been shown to be beneficial to the cardiovascular system due to their antiatherogenic, anti-inflammatory, anticoagulative and antihypertensive effects (Deng et al 2020 ; Pechanova et al 2020 ; Sato and Mukai 2020 ). The AIN-93M diet is a flavonoid-deficient diet.…”

Section: The Possible Cardioprotective Effects Of Quercetin-like Plant Flavonoids As Cofactors Of Cox-2mentioning

confidence: 99%

New horizons in the roles and associations of COX-2 and novel natural inhibitors in cardiovascular diseases

Chen

Zhong

Feng

et al. 2021

Mol Med

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Age-related cardiovascular disease is the leading cause of death in elderly populations. Coxibs, including celecoxib, valdecoxib, etoricoxib, parecoxib, lumiracoxib, and rofecoxib, are selective cyclooxygenase-2 (COX-2) inhibitors used to treat osteoarthritis and rheumatoid arthritis. However, many coxibs have been discontinued due to adverse cardiovascular events. COX-2 contains cyclooxygenase (COX) and peroxidase (POX) sites. COX-2 inhibitors block COX activity without affecting POX activity. Recently, quercetin-like flavonoid compounds with OH groups in their B-rings have been found to serve as activators of COX-2 by binding the POX site. Galangin-like flavonol compounds serve as inhibitors of COX-2. Interestingly, nabumetone, flurbiprofen axetil, piketoprofen-amide, and nepafenac are ester prodrugs that inhibit COX-2. The combination of galangin-like flavonol compounds with these prodrug metabolites may lead to the development of novel COX-2 inhibitors. This review focuses on the most compelling evidence regarding the role and mechanism of COX-2 in cardiovascular diseases and demonstrates that quercetin-like compounds exert potential cardioprotective effects by serving as cofactors of COX-2.

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Therapeutic Potential of Polyphenols-Loaded Polymeric Nanoparticles in Cardiovascular System

Cited by 41 publications

References 160 publications

Curcumin as a Natural Remedy for Atherosclerosis: A Pharmacological Review

Curcumin as a Natural Remedy for Atherosclerosis: A Pharmacological Review

Curcumin as a Natural Remedy for Atherosclerosis: A Pharmacological Review

New horizons in the roles and associations of COX-2 and novel natural inhibitors in cardiovascular diseases

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