Therapeutic Potential of Pomegranate in Metabolic Disorders

Akaberi, Maryam; Boghrati, Zahra; Sahebkar, Amirhossein; Emami, Seyed Ahmad

doi:10.1007/978-3-030-73234-9_28

Cited by 14 publications

(5 citation statements)

References 91 publications

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“…[31,32] Despite their effectiveness, the side effects of those treatments would often cause a burden to patients. [33,34] CUR, a natural compound isolated from the root of Curcuma longa, [35] can induce apoptosis in a variety of different tumor cell lines, and hence can be used as an adjunct to other forms of cancer treatment, including the combination of radiotherapy and chemotherapy [36] and can exert anti-inflammatory and anti-oxidation effects. [37] CUR is often used as a dietary supplement to prevent PCa.…”

Section: Discussionmentioning

confidence: 99%

Curcumin inhibits prostate cancer by upregulating miR‐483‐3p and inhibiting UBE2C

Li,

Wang,

Wang

et al. 2024

J Biochem & Molecular Tox

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Prostate cancer (PCa) is an extremely common genitourinary malignancy among elderly men. Many evidence have shown the efficacy of curcumin (CUR) in inhibiting the progression of PCa. However, the pharmacological function of CUR in PCa is still not quite clear. In this research, CUR was found to suppress the proliferation and enhance the apoptotic rate in in vitro PCa cell models in a dose‐ and time‐dependent manner. In a xenograft animal model, the administration of CUR contributed to a significant decrease in the growth of the xenograft tumor induced by the transplanted PC‐3 cells. Ubiquitin‐conjugating enzyme E2 C is implicated in the modulation of multiple types of cancers. In humans, the expression levels of UBE2C are significantly higher in PCa versus benign prostatic hyperplasia. Treatment with CUR decreased the expression of UBE2C, whereas it increased miR‐483‐3p expression. In contrast with the control mice, the CUR‐treated mice showed a significant reduction in UBE2C and Ki‐67 in PCa cells. The capability of proliferation, migration, and invasion of PCa cells was inhibited by the knockdown of UBE2C mediated by siRNA. Furthermore, dual luciferase reporter gene assay indicated the binding of miR‐483‐3p to UBE2C. In summary, CUR exerts its antitumor effects through regulation of the miR‐483‐3p/UBE2C axis by decreasing UBE2C and increasing miR‐483‐3p. The findings may also provide new molecular markers for PCa diagnosis and treatment.

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Section: Discussionmentioning

confidence: 99%

Curcumin inhibits prostate cancer by upregulating miR‐483‐3p and inhibiting UBE2C

Li,

Wang,

Wang

et al. 2024

J Biochem & Molecular Tox

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“…A simple one-step purification using liquid-liquid extraction with the 10% v/v water in methanol can be used for preparing pomegranate peel extract rich in ellagic acid [20]. Studies have shown that ellagic acid extracted from pomegranate peels can be consumed and is relatively safe and non-toxic to the human body, with topical anti-inflammatory and analgesic activities [21,22]. However, ellagic acid prepared from gallnuts, a traditional source, is limited to external use.…”

Section: Introductionmentioning

confidence: 99%

Ultra-High-Performance Liquid Chromatography–Electrospray Ionization–High-Resolution Mass Spectrometry for Distinguishing the Origin of Ellagic Acid Extracts: Pomegranate Peels or Gallnuts

Wei,

Xu,

Zhang

et al. 2024

Molecules

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Ellagic acid, known for its various biological activities, is widely used. Ellagic acid from pomegranate peels is safe for consumption, while that from gallnuts is only suitable for external use. However, there is currently no effective method to confirm the source of ellagic acid. Therefore, this study establishes an analysis method using ultra-high-performance liquid chromatography–electrospray ionization–high-resolution mass spectrometry (UHPLC-ESI-HR-MS) to identify the components of crude ellagic acid extracts from pomegranate peels and gallnuts. The analysis revealed that there was a mix of components in the crude extracts, such as ellagic acid, palmitic acid, oleic acid, stearic acid, and 9(10)-EpODE. Furthermore, it could be observed that ellagic acid extracted from gallnuts contained toxic substances such as anacardic acid and ginkgolic acid (15:1). These components could be used to effectively distinguish the origin of ellagic acid from pomegranate peels or gallnuts. Additionally, a rapid quantitative analysis method using UHPLC-ESI-MS with multiple reaction monitoring (MRM) mode was developed for the quality control of ellagic acid products, by quantifying anacardic acid and ginkgolic acid (15:1). It was found that one of three ellagic acid health care products contained ginkgolic acid (C15:1) and anacardic acid at more than 1 ppm.

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“…14 Multiple clinical studies also corroborated the findings from animal models. 15,16 For example, the consump-tion of a standardized PE for four weeks resulted in a significant reduction in skin wrinkle severity. 17 Moreover, pomegranate juice is seemingly more potent in reducing the postprandial glycemic response as well as the risk factor of developing type 2 diabetes.…”

Section: Introductionmentioning

confidence: 99%

Multi-omics analysis detected multiple pathways by which pomegranate punicalagin exerts its biological effects in modulating host–microbiota interactions in murine colitis models

Liu

Smith²,

Wang³

et al. 2023

Food Funct.

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Therapeutic Potential of Pomegranate in Metabolic Disorders

Cited by 14 publications

References 91 publications

Curcumin inhibits prostate cancer by upregulating miR‐483‐3p and inhibiting UBE2C

Curcumin inhibits prostate cancer by upregulating miR‐483‐3p and inhibiting UBE2C

Ultra-High-Performance Liquid Chromatography–Electrospray Ionization–High-Resolution Mass Spectrometry for Distinguishing the Origin of Ellagic Acid Extracts: Pomegranate Peels or Gallnuts

Multi-omics analysis detected multiple pathways by which pomegranate punicalagin exerts its biological effects in modulating host–microbiota interactions in murine colitis models

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