Therapeutic Potential of Pyrazole Containing Compounds: an Updated Review

Kapri, Anandi; Gupta, Nitin; Nain, Sumitra

doi:10.1007/s11094-024-03141-x

Pharm Chem J

2024

DOI: 10.1007/s11094-024-03141-x

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Therapeutic Potential of Pyrazole Containing Compounds: an Updated Review

Anandi Kapri,

Nitin Gupta,

Sumitra Nain

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2024

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Phenol (bio)isosteres in drug design and development

Dunker,

Schlegel,

Junker

2024

Archiv der Pharmazie

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Due to their versatile properties, phenolic compounds are integral to various biologically active molecules, including many pharmaceuticals. However, their application in drug design is often hindered by issues such as poor oral bioavailability, rapid metabolism, and potential toxicity. This review explores the use of phenol bioisosteres–structurally similar compounds that can mimic the biological activity of phenols while potentially offering improved drug‐like properties. We provide an extensive analysis of various phenol bioisosteres, including benzimidazolones, benzoxazolones, indoles, quinolinones, and pyridones, highlighting their impact on the pharmacokinetic and pharmacodynamic profiles of drugs. Case studies illustrate the successful application of these bioisosteres in enhancing metabolic stability, receptor selectivity, and overall therapeutic efficacy. Additionally, the review addresses the challenges associated with phenol bioisosterism, such as maintaining potency and avoiding undesirable side effects. By offering a detailed examination of current strategies and potential future directions, this review serves as a valuable resource for medicinal chemists seeking to optimize phenolic scaffolds in drug development. The insights provided herein aim to facilitate the design of more effective and safer therapeutic agents through strategic bioisosteric modifications.

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Phenol (bio)isosteres in drug design and development

Dunker,

Schlegel,

Junker

2024

Archiv der Pharmazie

View full text Add to dashboard Cite

show abstract

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Therapeutic Potential of Pyrazole Containing Compounds: an Updated Review

Cited by 1 publication

References 34 publications

Phenol (bio)isosteres in drug design and development

Phenol (bio)isosteres in drug design and development

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