Therapeutic potential of stem cells for treatment of neurodegenerative diseases

Ahmadian-Moghadam, Hamid; Sadat‐Shirazi, Mitra‐Sadat; Zarrindast, Mohammad‐Reza

doi:10.1007/s10529-020-02886-1

Cited by 29 publications

(18 citation statements)

References 273 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Cell-based therapy, which may provide structural and functional reconstruction in brain regions, is a potential strategy for neurodegenerative diseases (Table 1 ) [ 20 , 44 , 45 ]. In HD, these related studies have been examined in different animal models.…”

Section: Huntington’s Diseasementioning

confidence: 99%

The regulatory roles of microRNAs toward pathogenesis and treatments in Huntington's disease

et al. 2021

View full text Add to dashboard Cite

Huntington’s disease (HD) is one of neurodegenerative diseases, and is defined as a monogenetic disease due to the mutation of Huntingtin gene. This disease affects several cellular functions in neurons, and further influences motor and cognitive ability, leading to the suffering of devastating symptoms in HD patients. MicroRNA (miRNA) is a non-coding RNA, and is responsible for gene regulation at post-transcriptional levels in cells. Since one miRNA targets to several downstream genes, it may regulate different pathways simultaneously. As a result, it raises a potential therapy for different diseases using miRNAs, especially for inherited diseases. In this review, we will not only introduce the update information of HD and miRNA, but also discuss the development of potential miRNA-based therapy in HD. With the understanding toward the progression of miRNA studies in HD, we anticipate it may provide an insight to treat this devastating disease, even applying to other genetic diseases.

show abstract

Section: Huntington’s Diseasementioning

confidence: 99%

The regulatory roles of microRNAs toward pathogenesis and treatments in Huntington's disease

et al. 2021

View full text Add to dashboard Cite

show abstract

“…Repairing the neural circuit by replacement of the dysfunctional neurons would represent an effective cure for neurodegenerative disorders. Nowadays, based on stem cell transplantation, neural stem cells which possess self-renewal and pluripotency have become a promising curative agent for neurodegenerative disorders treatment ( Lindvall et al, 2004 ; McGinley et al, 2018 ; Reidling et al, 2018 ; Song et al, 2018 ; Yang et al, 2018 ; Ahmadian-Moghadam et al, 2020 ; Derakhshankhah et al, 2020 ; Xapelli et al, 2020 ). Following transplantation, neural stem cells can differentiate into neural subtype cells, including neurons, astrocytes, and oligodendrocytes, in vivo ( Gage, 2000 ).…”

Section: Introductionmentioning

confidence: 99%

Oriented Neural Spheroid Formation and Differentiation of Neural Stem Cells Guided by Anisotropic Inverse Opals

Xia

Shang

Chen

et al. 2020

Front. Bioeng. Biotechnol.

View full text Add to dashboard Cite

Isotropic inverse opal structures have been extensively studied for the ability to manipulate cell behaviors such as attachment, migration, and spheroid formation. However, their use in regulate the behaviors of neural stem cells has not been fully explored, besides, the isotropic inverse opal structures usually lack the ability to induce the oriented cell growth which is fundamental in neural regeneration based on neural stem cell therapy. In this paper, the anisotropic inverse opal substrates were obtained by mechanically stretching the poly (vinylidene fluoride) (PVDF) inverse opal films. The anisotropic inverse opal substrates possessed good biocompatibility, optical properties and anisotropy, provided well guidance for the formation of neural spheroids, the alignment of neural stem cells, the differentiation of neural stem cells, the oriented growth of derived neurons and the dendritic complexity of the newborn neurons. Thus, we conclude that the anisotropic inverse opal substrates possess great potential in neural regeneration applications.

show abstract

“…This result illustrates the potential of idebenone for treating neurodegenerative diseases including PD. [42] 3α-acetoxyeudesma-1,4(15),11( 13)-trien-12,6aolide [AETO, Figure 2C] is a compound isolated from the leaves of Laurusnobilis L., AETO (0.4, 2, and 10 μM) decreases the active form of caspase-3 and the levels of p53, which were accompanied by increased levels of Bcl-2 in a dose-dependent manner. Flow cytometry and Western blot analyses showed that AETO significantly inhibits DAinduced apoptosis and suppresses intracellular tyrosinase activity, ROS generation, quinoprotein, and SNCA formation.…”

Section: Antioxidant Compounds In Experimental Models Of Pdmentioning

confidence: 99%

Untitled

Sarvananda¹

2021

IJPSCR

View full text Add to dashboard Cite

Neurodegenerative movement disorder of the central nervous system (CNS) (Parkinson's disease [PD]) is characterized by necrosis of dopaminergic neurons in the substantia nigra pars compacta region of the midbrain. The etiology of PD is still unknown and is believed to be multifactorial, oxidative stress and mitochondrial dysfunction are widely considered major consequences, which provide important clues to the disease mechanisms. Studies have showed the role of free radicals and oxidative stress that contributes to the cascade of events leading to dopamine cell degeneration in PD. In general, in-built protective mechanisms consisting of enzymatic and non-enzymatic antioxidants in the CNS play decisive roles in preventing neuronal cell loss due to free radicals. However, the ability to produce these antioxidants decreases with aging. Therefore, antioxidant therapy alone or in combination with current treatment methods may represent an attractive strategy for treating or preventing the neurodegeneration seen in PD. Here, we summarize the recent discoveries of potential antioxidant compounds for modulating free-radical mediated oxidative stress leading to neurotoxicity in PD.

show abstract

Therapeutic potential of stem cells for treatment of neurodegenerative diseases

Cited by 29 publications

References 273 publications

The regulatory roles of microRNAs toward pathogenesis and treatments in Huntington's disease

The regulatory roles of microRNAs toward pathogenesis and treatments in Huntington's disease

Oriented Neural Spheroid Formation and Differentiation of Neural Stem Cells Guided by Anisotropic Inverse Opals

Untitled

Contact Info

Product

Resources

About