2018
DOI: 10.3389/fimmu.2018.02042
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Therapeutic Potential of the Gut Microbiota in the Prevention and Treatment of Sepsis

Abstract: Alongside advances in understanding the pathophysiology of sepsis, there have been tremendous strides in understanding the pervasive role of the gut microbiota in systemic host resistance. In pre-clinical models, a diverse and balanced gut microbiota enhances host immunity to both enteric and systemic pathogens. Disturbance of this balance increases susceptibility to sepsis and sepsis-related organ dysfunction, while restoration of the gut microbiome is protective. Patients with sepsis have a profoundly distor… Show more

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Cited by 129 publications
(109 citation statements)
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“…The impairments of gut during sepsis are mainly reflected in the disruption of epithelial integrity, leading to the intestinal hyperpermeability. Increased gut permeability was directly associated with bacterial translocation, systemic inflammatory response, and MOF [16]. In the present study, we showed that pretreatment of MitoQ alleviated the LPS-induced intestinal mucosal injury.…”
Section: Discussionsupporting
confidence: 62%
“…The impairments of gut during sepsis are mainly reflected in the disruption of epithelial integrity, leading to the intestinal hyperpermeability. Increased gut permeability was directly associated with bacterial translocation, systemic inflammatory response, and MOF [16]. In the present study, we showed that pretreatment of MitoQ alleviated the LPS-induced intestinal mucosal injury.…”
Section: Discussionsupporting
confidence: 62%
“…Having phenotypically characterized the salutary effects of doxycycline for survival to sepsis, tissue homeostasis, and metabolism, we then turned to the mechanistic identification doxycycline-induced perturbations leading to disease tolerance. The role of microbiota in host physiology has been increasingly acknowledged, with extensive research focusing on its therapeutic potential in sepsis (Haak et al, 2018) including its role in disease tolerance (Schieber et al, 2015). As an antibiotic, doxycycline induces substantial changes in gut microbiome composition (data not shown) that may indirectly affect host fitness.…”
Section: Low-dose Doxycycline Affects Mitochondrial Function In Vivomentioning
confidence: 99%
“…Although commensal bacteria reside innocuously in the gut mucosa, they share common microbeassociated molecular patterns (MAMPs) with the pathogenic bacteria that invade through the intestinal epithelium [46,47]. Commensal bacteria, therefore, have the potential to activate immune responses through pattern recognition receptors such as toll-like receptors (TLRs) and nucleotide-oligomerization domain (NOD)-like receptors (NLRs) [47].…”
Section: Discussionmentioning
confidence: 99%