Therapeutic Potential of Tramadol and Dextromethorphan on Vincristine Induced Peripheral Neuropathy in Rats

Zbârcea, Cristina Elena

doi:10.31925/farmacia.2018.6.17

Cited by 10 publications

(13 citation statements)

References 16 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Non-clinical studies are commonly used to determine the therapeutic potential of xenobiotics [ 45 , 46 ]. The analgesic effect was quantified by two pharmacological tests, widely used to investigate the analgesic action of xenobiotics: acetic acid-induced writhing test and hot plate test.…”

Section: ⧉ Discussionmentioning

confidence: 99%

New 2-(4-(4-bromophenylsulfonyl)phenyl)-4-arylidene-oxazol-5(4H)-ones: analgesic activity and histopathological assessment

Bărbuceanu

Roşca

Apostol

et al. 2020

Rom J Morphol Embryol

View full text Add to dashboard Cite

This is an open-access article distributed under the terms of a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International Public License, which permits unrestricted use, adaptation, distribution and reproduction in any medium, non-commercially, provided the new creations are licensed under identical terms as the original work and the original work is properly cited. ORIGINAL PAPER New 2-(4-(4-bromophenylsulfonyl)phenyl)-4-arylideneoxazol-5(4H)-ones: analgesic activity and histopathological assessment FLORICA BĂRBUCEANU 1,2) , ELENA-VALENTINA ROŞCA 3) , THEODORA-VENERA APOSTOL 3) , OANA-CRISTINA ŞEREMET 4) , CONSTANTIN DRĂGHICI 5) , DRAGOŞ PAUL MIHAI 4) , SIMONA NEGREŞ 4) , GEORGE MIHAI NIŢULESCU 6) , ŞTEFANIA-FELICIA BĂRBUCEANU 3)

show abstract

Section: ⧉ Discussionmentioning

confidence: 99%

New 2-(4-(4-bromophenylsulfonyl)phenyl)-4-arylidene-oxazol-5(4H)-ones: analgesic activity and histopathological assessment

Bărbuceanu

Roşca

Apostol

et al. 2020

Rom J Morphol Embryol

View full text Add to dashboard Cite

show abstract

“…Reports of widespread clinical NP CT benefits provide an impetus for additional future investigations. Regarding this matter, a demonstration of CT benefits by several studies in animals could also provide a rationale for studies in this and other directions [50,[77][78][79][80][81][82][83][84][85].…”

Section: Implications For Researchmentioning

confidence: 99%

Combination Therapy for Neuropathic Pain: A Review of Recent Evidence

Serrano

Carnaval

Videla

2021

JCM

View full text Add to dashboard Cite

Pharmacological treatment is not very effective for neuropathic pain (NP). A progressive decrease in the estimated effect of NP drugs has been reported, giving rise to an increase in the use of the multimodal analgesic approach. We performed a new independent review to assess whether more and better-quality evidence has become available since the last systematic review. We evaluated the efficacy, tolerability, and safety of double-blinded randomized controlled trials involving only adult participants and comparing combination therapy (CT: ≥2 drugs) with a placebo and/or at least one other comparator with an NP indication. The primary outcome assessed was the proportion of participants reporting ≥50% pain reductions from baseline. The secondary outcome assessed was the proportion of drop-outs due to treatment-emergent adverse events. After removing duplicates, 2323 citations were screened, with 164 articles assessed for eligibility, from which 16 were included for qualitative analysis. From the latter, only five lasted for at least 12 weeks and only six complied with the required data for complete analysis. CT has been adopted for years without robust evidence. Efforts have been made to achieve better-quality evidence, but the quality has not improved over the years. In this regard, guidelines for NP should attempt to make recommendations about CT research, prioritizing which combinations to analyze.

show abstract

“…Reports of widespread clinical NP CT benefits provide an urge for additional future investigations. In this matter, demonstration of CT benefits by several studies in animals could also provide a rationale in this and other directions [77][78][79][80][81][82][83][84][85][86].…”

Section: Implications For Researchmentioning

confidence: 99%

“…For instance, in non-clinical studies, potentiation of morphine by GBP has been validated in a chronic constriction injury model of NP [77][78]. Likewise, for the combination of GBP and tramadol in a partial sciatic nerve ligation model [79], or peripheral neuropathy induced by paclitaxel [80], and in diabetic neuropathy [81]. Furthermore, no significant drug-to-drug interaction between PGB and tramadol has been already studied in healthy volunteers [87], and, surprisingly, there has been a recent proposal to make a compound tablet with tramadol and GBP [88], even though these combinations have not yet been validated in proper RCTs.…”

Section: Implications For Researchmentioning

confidence: 99%

Combination Therapy for Neuropathic Pain. A Systematic Review

Serrano¹,

Carnaval²,

S³

2021

Preprint

View full text Add to dashboard Cite

Pharmacological treatment is poorly effective for neuropathic pain (NP). A progressive decrease in the estimated effect of NP drugs has been reported, giving rise to an increase in multimodal analgesic approach. We performed a systematic review to assess whether there is more and better-quality evidence available since the last review. We evaluated the efficacy, tolerability and safety of double-blind randomized controlled trials involving only adult participants comparing combination therapy (CT: ≥ 2 drugs) to placebo and/or at least one other comparator with NP indication. The primary outcome was the proportion of participants reporting ≥ 50% pain reduction from baseline. Secondary outcome was the proportion of drop-outs due to treatment-emergent-adverse-events. After removing duplicates, 2323 citations were screened. 164 articles were assessed for eligibility, from which 16 were included for qualitative analysis. From the latter, only 5 lasted for at least 12 weeks and only 6 complied with required data for complete analysis, but not for meta-analysis. CT has been adopted for years without robust evidence. Efforts to achieve better quality evidence have not improved over the years. In this regard, guidelines for NP should attempt to make recommendations on CT research, prioritizing which combinations to analyze.

show abstract

Therapeutic Potential of Tramadol and Dextromethorphan on Vincristine Induced Peripheral Neuropathy in Rats

Cited by 10 publications

References 16 publications

New 2-(4-(4-bromophenylsulfonyl)phenyl)-4-arylidene-oxazol-5(4H)-ones: analgesic activity and histopathological assessment

New 2-(4-(4-bromophenylsulfonyl)phenyl)-4-arylidene-oxazol-5(4H)-ones: analgesic activity and histopathological assessment

Combination Therapy for Neuropathic Pain: A Review of Recent Evidence

Combination Therapy for Neuropathic Pain. A Systematic Review

Contact Info

Product

Resources

About