“…In vitro, rutin decreased Aβ42‐induced cytotoxicity, oxidative stress and pro‐inflammatory cytokines in SH‐SY5Y neuroblastoma cells (Wang et al ., ), and protected pheochromocytoma (PC12) cells against 6‐hydroxydopamine‐induced neurotoxicity by improving antioxidant activities (Magalingam et al ., ). Moreover, in vivo , rutin protected rats against brain injury by several insults, such as trimethyltin (Koda et al ., ), streptozotocin (Kamalakkannan and Stanely Mainzen Prince, ), 6‐hydroxydopamine (Khan et al ., ) and focal ischaemia (Khan et al ., ; Annapurna et al ., ; Rodrigues et al ., ), via its antioxidative and anti‐inflammatory properties. Importantly, rutin treatment attenuated cognitive deficits in rats with repeated cerebral ischaemia (Pu et al ., ), trimethyltin treatment (Koda et al ., ), kindled with pentylenetetrazole (Nassiri‐Asl et al ., ), given i.c.v infusions of streptozotocin (Javed et al ., ) or aged rats (Pyrzanowska et al ., ).…”