Therapeutic prospects of ceRNAs in COVID-19

Liu, Lin; Zhang, Yao; Chen, Yu; Zhao, Yueshui; Shen, Jing; Wu, Xu; Li, Mingxing; Chen, Meijuan; Li, Xiaobing; Sun, Yuhong; Gu, Li H.; Li, Wanping; Wang, Fang; Yao, Ling; Zhang, Zhuo; Xiao, Zhangang; Du, Fukuan

doi:10.3389/fcimb.2022.998748

Cited by 5 publications

(4 citation statements)

References 160 publications

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“…At this point, we focused on lncRNAs because several studies have reported their association with COVID-19. [74][75][76] In this section, XIST was omitted because changes in its expression were reported in infected mouse cells (not human cells). In addition, as shown in Figure 6f, several studies have confirmed some differences in the expression of MALAT1 and NEAT1 in different human cells or human PBMCs infected with SARS-CoV-2.…”

Section: Cerna Network Of Mrna-mirna-lncrnamentioning

confidence: 99%

Elucidating the Role of a Shared lncRNA-miRNA-mRNA Network in Exacerbating Parkinson’s Disease Symptoms in the Context of COVID-19 Infection

Yousefi,

Hashemi,

Peymani

et al. 2024

Gene Expr

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Background and objectives: Parkinson's disease (PD) is a common neurodegenerative disorder with unclear molecular mechanisms. Noncoding RNAs, such as microRNAs (miRNAs) and long noncoding RNAs (lncRNAs), have been identified as critical regulators of gene expression. This study aimed to investigate the triple network of lncRNA-miRNA-mRNA, known as competing endogenous RNAs (ceRNAs), and to identify essential lncRNAs that regulate PD-related gene expression through their target miRNAs. The study also identified a common triple network between COVID-19 and PD that may contribute to exacerbating PD symptoms. Methods:A bioinformatics approach was employed to construct a PD ceRNA network using common PD genes, miRNAs and lncRNAs with the highest interaction with their targets. Also, a PD-COVID-19 triple network was constructed by integrating PD network nodes into the COVID-19 network. Results:The PD ceRNA network comprised 34 nodes, including 12 lncRNAs, 16 miRNAs with interconnections and six mRNAs, some of which were related to COVID-19. The network showed parallel expression of the SNCA and PARK7 genes as well as the NEAT1 and MALAT1 lncRNAs in both PD and COVID-19. Conclusions:This study provide insights into the molecular mechanisms underlying the worsening of symptoms in PD patients with COVID-19. The PD and COVID-19 ceRNA network indicates that coronavirus could worsen PD symptoms by altering the expression of some genes related to PD. Therefore, COVID-19 could dysregulate the common RNAs involved in PD through lncRNAs, miRNAs.

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Section: Cerna Network Of Mrna-mirna-lncrnamentioning

confidence: 99%

Elucidating the Role of a Shared lncRNA-miRNA-mRNA Network in Exacerbating Parkinson’s Disease Symptoms in the Context of COVID-19 Infection

Yousefi,

Hashemi,

Peymani

et al. 2024

Gene Expr

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“…49 Studies have revealed lncRNAs like MALAT1 and TUG1 as regulators of inflammatory factors such as IL-6 and NLRP3, with implications for cardiovascular disease. 68 Further research uncovered that lncRNAs such as MIR503HG and NFIA-AS1 regulate apoptosis, ECM integrity, and inflammation in vascular disease contexts. 46,69,70…”

Section: Long Noncoding Rna and Reactive Oxygen Species In Vascular S...mentioning

confidence: 99%

The Role of Long Noncoding RNAs in Vascular Smooth Muscle Cell Phenotype and the Pathogenesis of Cardiovascular and Cerebrovascular Aneurysms

Deng,

Ye,

et al. 2024

Journal of Cardiovascular Pharmacology

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Aneurysms are localized dilations of blood vessels, which can expand to 50% of the original diameter. They are more common in cardiovascular and cerebrovascular vessels. Rupture is one of the most dangerous complications. The pathophysiology of aneurysms is complex and diverse, often associated with progressive vessel wall dysfunction resulting from vascular smooth muscle cell (VSMC) death and abnormal extracellular matrix synthesis and degradation. Multiple studies have shown that long non-coding RNAs (lncRNAs) play a significant role in the progression of cardiovascular and cerebrovascular diseases. Therefore, it is necessary to find and summarize them. LncRNAs control gene expression and disease progression by regulating target mRNA or miRNA, and are biomarkers for the diagnosis and prognosis of aneurysmal cardiovascular and cerebrovascular diseases. This review explores the role, mechanism and clinical value of lncRNAs in aneurysms, providing new insights for a deeper understanding of the pathogenesis of cardiovascular and cerebrovascular aneurysms.

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“…The regulation of miRNAs by TFs is critical, and aberrant regulation of miRNAs by TFs can cause phenotypic variations and diseases 89 . In addition, as competitive endogenous RNA (ceRNA), lncRNA and circRNA competitively bind miRNA through miRNA response elements (MREs) to inhibit mRNA degradation mediated by miRNAs targeting, which is reflected in lncRNA/circRNA-miRNA-mRNA cascade regulation network 88 , 90 . LncRNAs can also be used as miRNA precursors, which can generate specific miRNAs by intracellular RNA cleavage and enhance the post-transcriptional regulation of target mRNAs 91 .…”

Section: Circulating Mirnas Involving In Covid-19-related Organ Dysfu...mentioning

confidence: 99%

Circulating microRNAs as emerging regulators of COVID-19

Liang¹,

Fang²,

Gao³

et al. 2023

Theranostics

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Coronavirus disease 2019 , an infectious disease caused by the novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), is a global pandemic that has high incidence rates, spreads rapidly, and has caused more than 6.5 million deaths globally to date. Currently, several drugs have been used in the clinical treatment of COVID-19, including antivirals (e.g., molnupiravir, baricitinib, and remdesivir), monoclonal antibodies (e.g., etesevimab and tocilizumab), protease inhibitors (e.g., paxlovid), and glucocorticoids (e.g., dexamethasone). Increasing evidence suggests that circulating microRNAs (miRNAs) are important regulators of viral infection and antiviral immune responses, including the biological processes involved in regulating COVID-19 infection and subsequent complications. During viral infection, both viral genes and host cytokines regulate transcriptional and posttranscriptional steps affecting viral replication. Virus-encoded miRNAs are a component of the immune evasion repertoire and function by directly targeting immune functions. Moreover, several host circulating miRNAs can contribute to viral immune escape and play an antiviral role by not only promoting nonstructural protein (nsp) 10 expression in SARS coronavirus, but among others inhibiting NOD-like receptor pyrin domain-containing (NLRP) 3 and IL-1β transcription. Consequently, understanding the expression and mechanism of action of circulating miRNAs during SARS-CoV-2 infection will provide unexpected insights into circulating miRNA-based studies. In this review, we examined the recent progress of circulating miRNAs in the regulation of severe inflammatory response, immune dysfunction, and thrombosis caused by SARS-CoV-2 infection, discussed the mechanisms of action, and highlighted the therapeutic challenges involving miRNA and future research directions in the treatment of COVID-19.

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Therapeutic prospects of ceRNAs in COVID-19

Cited by 5 publications

References 160 publications

Elucidating the Role of a Shared lncRNA-miRNA-mRNA Network in Exacerbating Parkinson’s Disease Symptoms in the Context of COVID-19 Infection

Elucidating the Role of a Shared lncRNA-miRNA-mRNA Network in Exacerbating Parkinson’s Disease Symptoms in the Context of COVID-19 Infection

The Role of Long Noncoding RNAs in Vascular Smooth Muscle Cell Phenotype and the Pathogenesis of Cardiovascular and Cerebrovascular Aneurysms

Circulating microRNAs as emerging regulators of COVID-19

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