Therapeutic red blood cell exchange in a child with sickle cell anaemia using the Spectra Optia^® apheresis system

The evaluation of a new apheresis device for automated red blood cell exchange procedures in patients with sickle cell disease

“…In three of the 16 depletion/exchange procedures performed, the savings were more than 250 mL and thus may have represented a full unit of blood savings. A recent report described the use of the SO depletion/exchange procedure in 10 of 11 procedures on an 11‐year‐old SCD patient. The report concluded that the isovolemic depletion phase reduced the amount of transfused RBC units, but quantitative results are not provided.…”

Iron depletion with a novel apheresis system in patients with hemochromatosis

“…A new apheresis system, the Spectra Optia (Terumo BCT, Lakewood, CO) has been recently introduced in the clinical setting. So far, studies about this new apheresis device report on mononuclear cell collection, on plasma‐exchange procedures, and on RBC exchange, respectively …”

Red blood cell exchange in children and adolescents with sickle cell disease

“…To this extent, most of the several instruments available to perform RBCX, i.e. COBE Spectra or Optia Spectra (TerumoBCT) and COM-TEC or Amicus (Fresenius Kabi), have been used for children (9,(11)(12)(22)(23)(24)(25).…”

“…However, the volume of RBC saved depends on the pre-apheresis features of the patient (weight, height, TBV and Hct) and the low TBVs observed in young children do not allow us to save significant numbers of RBCUs or to significantly space out the procedures. There are only anecdotal data of IHD-RBCX in children (24,26).…”