Therapeutic Resevoirs: Implantable Therapeutic Reservoir Systems for Diverse Clinical Applications in Large Animal Models (Adv. Healthcare Mater. 11/2020)

Duffy, Garry P.; Robinson, Scott T.; O'Connor, Raymond G.; Wylie, Robert B.; Mauerhofer, Ciaran; Bellavia, Gabriella; Straino, Stefania; Cianfarani, Francesca; Mendez, Keegan; Beatty, Rachel; Levey, Ruth E.; O’Sullivan, Janice; McDonough, Liam; Kelly, Helena; Roche, Ellen T.; Dolan, Eimear

doi:10.1002/adhm.202070035

Cited by 2 publications

(3 citation statements)

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“…A sensor-enabled macroencapsulation device was manufactured following some of the techniques previously described, [57][58][59] as shown in Figure S3, Supporting Information. This device was composed of two layers of 6 mil thermoplastic polyurethane (TPU, American Polyfilm Inc) and with a capacity of 5 mL.…”

Section: Macroencapsulation Device Manufacturingmentioning

confidence: 99%

A Predictive Oxygen Durability Model to Analyze Oxygen Consumption of Insulin Producing Cells Encapsulated Within a Highly Oxygenated Hydrogel

Domingo‐Lopez

Levey

Brennan

et al. 2022

Adv Materials Technologies

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Cell transplantation aims to regenerate damaged tissues and cure currently incurable diseases, such as Type 1 diabetes. Post‐transplantation cell survival is highly limited by the lack of suitable support matrix (anoikis) and insufficient oxygen supply (hypoxia), which is aggravated when using macroencapsulation devices. Graft failure can be overcome by encapsulation in extracellular matrix (ECM)‐based hydrogels with high oxygen capacity. Estimation of the oxygen durability in these systems is critical for the design of hydrogel loaded macroencapsulation devices aimed to increase graft survival. In this study, a novel hyaluronic acid/perfluorocarbon biomaterial (Oxygel) is formulated, oxygenated, and characterized. Oxygel exhibits shear thinning and self‐healing properties while it can carry high oxygen payloads and slowly release them for 90 h, exhibiting a 14.5 times smaller oxygen diffusivity than PBS. In parallel, a model able to predict the oxygen durability within Oxygel upon cell encapsulation is developed and experimentally validated in vitro. Correlations between model estimations and experimental results are found, demonstrating the validity of the model to analyze oxygen durability. The application of this mathematical model to oxygenated cell scaffolds (such as Oxygel) holds great promise to improve cell transplantation success.

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Section: Macroencapsulation Device Manufacturingmentioning

confidence: 99%

A Predictive Oxygen Durability Model to Analyze Oxygen Consumption of Insulin Producing Cells Encapsulated Within a Highly Oxygenated Hydrogel

Domingo‐Lopez

Levey

Brennan

et al. 2022

Adv Materials Technologies

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“…[ 64 , 84 ] Intramuscular implant sites are promising in this regard as they a have higher affinity for neovascularization, [ 85 ] and can be accessed minimally invasively with specialized delivery devices. [ 86 ] The intraperitoneal space has also been explored as a potential site of implantation, as the peritoneal cavity can accommodate large volumes of cells that are required to reverse T1D in patients. However, accessing this space can result in numerous complications associated with intra‐abdominal procedures.…”

Section: Sustaining Sc‐islet Viability In a Temporally Dynamic Environmentmentioning

confidence: 99%

“…Hence, multiple islet infusions are often required to reverse insulin dependence. [ 186 ] Many of the commercially available [ 5 , 80 ] and research stage devices [ 86 , 176 , 187 ] have incorporated features (tubing and self‐sealing subcutaneous or transcutaneous ports) to enable the repeated delivery of cell cargo. This design consideration is particularly relevant to allow dosing and cargo adjustment if one thinks about future incorporation of continuous sensing of implant function.…”

Section: Minimizing Foreign Body Responsementioning

confidence: 99%

Design Considerations for Macroencapsulation Devices for Stem Cell Derived Islets for the Treatment of Type 1 Diabetes

et al. 2021

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Stem cell derived insulin producing cells or islets have shown promise in reversing Type 1 Diabetes (T1D), yet successful transplantation currently necessitates long‐term modulation with immunosuppressant drugs. An alternative approach to avoiding this immune response is to utilize an islet macroencapsulation device, where islets are incorporated into a selectively permeable membrane that can protect the transplanted cells from acute host response, whilst enabling delivery of insulin. These macroencapsulation systems have to meet a number of stringent and challenging design criteria in order to achieve the ultimate goal of reversing T1D. In this progress report, the design considerations and functional requirements of macroencapsulation systems are reviewed, specifically for stem‐cell derived islets (SC‐islets), highlighting distinct design parameters. Additionally, a perspective on the future for macroencapsulation systems is given, and how incorporating continuous sensing and closed‐loop feedback can be transformative in advancing toward an autonomous biohybrid artificial pancreas.

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Therapeutic Resevoirs: Implantable Therapeutic Reservoir Systems for Diverse Clinical Applications in Large Animal Models (Adv. Healthcare Mater. 11/2020)

Cited by 2 publications

References 0 publications

A Predictive Oxygen Durability Model to Analyze Oxygen Consumption of Insulin Producing Cells Encapsulated Within a Highly Oxygenated Hydrogel

A Predictive Oxygen Durability Model to Analyze Oxygen Consumption of Insulin Producing Cells Encapsulated Within a Highly Oxygenated Hydrogel

Design Considerations for Macroencapsulation Devices for Stem Cell Derived Islets for the Treatment of Type 1 Diabetes

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