2016
DOI: 10.1007/s12038-016-9624-y
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Therapeutic resistance and cancer recurrence mechanisms: Unfolding the story of tumour coming back

Abstract: Cancer recurrence is believed to be one of the major reasons for the failure of cancer treatment strategies. This biological phenomenon could arise from the incomplete eradication of tumour cells after chemo- and radiotherapy. Recent developments in the design of models reflecting cancer recurrence and in vivo imaging techniques have led researchers to gain a deeper and more detailed insight into the mechanisms underlying tumour relapse. Here, we provide an overview of three important drivers of recurrence inc… Show more

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Cited by 41 publications
(34 citation statements)
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“…The resultant budding daughter cells begin to divide by mitosis and transiently display stem cell properties, and subsequently experience a complex life cycle eventually leading to the development of highly metastatic and therapy resistant descendants. This parasexual mode of somatic reduction division of MNGCs (neosis) has been reported from different laboratories for human ovarian [88,116], breast [87] and colon carcinoma cell lines [83] as well as other biological systems [122,123,124,125,126,127,128]. …”
Section: Fate Of Growth-arrested Cancer Cellsmentioning
confidence: 70%
“…The resultant budding daughter cells begin to divide by mitosis and transiently display stem cell properties, and subsequently experience a complex life cycle eventually leading to the development of highly metastatic and therapy resistant descendants. This parasexual mode of somatic reduction division of MNGCs (neosis) has been reported from different laboratories for human ovarian [88,116], breast [87] and colon carcinoma cell lines [83] as well as other biological systems [122,123,124,125,126,127,128]. …”
Section: Fate Of Growth-arrested Cancer Cellsmentioning
confidence: 70%
“…The resultant budding daughter cells begin to divide by mitosis and transiently display stem cell properties, and subsequently experience a complex life cycle eventually leading to the development of highly metastatic and therapy resistant descendants. This parasexual mode of somatic reduction division of MNGCs (neosis) has been reported from different laboratories for human ovarian [88,116], breast [87] and colon carcinoma cell lines [83] as well as other biological systems [122][123][124][125][126][127][128].…”
Section: Genome Reduction and Neosis Of Mngcsmentioning
confidence: 78%
“…It has also been shown that resveratrol induces apoptosis via inhibiting the PI3K/Akt/mTOR pathway [79,120,[127][128][129][130][131], modulating the mitogen-activated protein kinase pathway (MAPK) [129,130,132], and inhibiting NF-ÎşB activation [133,134]. Resveratrol triggered apoptosis within human T-cell acute lymphoblastic leukemia MOLT-4 cells by abrogating Akt phosphorylation, and subsequently preventing GSK3β from being activated [135].…”
Section: Anti-tumor-promotion Activitymentioning
confidence: 99%
“…Intriguingly, emerging studies have found that PGCCs could form numerous small mononuclear cells, which process is termed neosis [24,25,27]. Also, increasing evidence showed that neosis deriving from PGCCs had a potential role in therapeutic resistance [27,28], which may be undervalued before. Unfortunately, the direct role of neosis in tumor repopulation or recurrence was poorly understood.…”
Section: Discussionmentioning
confidence: 99%
“…Before the demise of PGCCs, some of them can undergo neosis characterized by karyokinesis via nuclear budding, asymmetrically intracellular cytokinesis and production of small mononuclear cells (be termed Raju cells) [24]. The newly formed Raju cells via neosis were considered to play a role in self-renewal in cancer [25,26], therapeutic resistance [27,28] due to their stem-like traits [29]. However, the de nite role of neosis in tumor recurrence or repopulation after therapy remains unclear.…”
Section: Introductionmentioning
confidence: 99%