Therapeutic response analysis in dogs with naturally occurring osteoarthritis

Gagnon, Alexandre; Brown, Dominique Xavier; Moreau, Maxim; Lussier, Bertrand; Otis, Colombe; Troncy, Éric

doi:10.1016/j.vaa.2017.07.008

Cited by 17 publications

(23 citation statements)

References 34 publications

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“…Our results demonstrated that MFAT injection significantly improved function and reduced pain and symptoms for at least 6 months with a trend of steady increase during time. Furthermore, we found that patients starting from a severe condition at baseline, mainly medium and large animals, showed greater improvements at 6 months compared to patients starting from a less severe condition, in line with a recent report investigating the therapeutic response in dogs with naturally occurring OA that revealed that dogs with a mild lameness are less prone to improve [47]. Pretreatment and posttreatment radiographic assessment indicated variable increase in osteophyte dimension and conformation at 3 and 6 months, in line with published data in which multiple injections of leukoreduced platelet rich plasma (PRP) were used in a canine model of cranial cruciate ligament and meniscal deficiency showing that radiographic OA significantly increased over time [48].…”

Section: Discussionsupporting

confidence: 91%

Intra-Articular Administration of Autologous Micro-Fragmented Adipose Tissue in Dogs with Spontaneous Osteoarthritis: Safety, Feasibility, and Clinical Outcomes

Zeira

Scaccia

Pettinari

et al. 2018

Stem Cells Translational Medicine

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Similar to the disease affecting humans, osteoarthritis (OA) is a painful musculoskeletal condition affecting 20% of the adult canine population. Several solutions have been proposed, but the results achieved to date are far from being satisfactory. New approaches, such as intra‐articular delivery of cells (including mesenchymal stromal cells), have been proposed. Among the many sources, the adipose tissue is considered very promising. We evaluated the safety, feasibility, and efficacy of a single intra‐articular injection of autologous and micro‐fragmented adipose tissue (MFAT) in 130 dogs with spontaneous OA. MFAT was obtained using a minimally invasive technique in a closed system and injected in the intra‐ and/or peri‐articular space. Clinical outcomes were determined using orthopedic examination and owners’ scores for up to 6 months. In 78% of the dogs, improvement in the orthopedic score was registered 1 month after treatment and continued gradually up to 6 months when 88% of the dogs improved, 11% did not change, and 1% worsened compared with baseline. Considering the owners’ scores at 6 months, 92% of the dogs significantly improved, 6% improved only slightly, and 2% worsened compared with baseline. No local or systemic major adverse effects were recorded. The results of this study suggest that MFAT injection in dogs with OA is safe, feasible, and beneficial. The procedure is time sparing and cost‐effective. Post injection cytological investigation, together with the clinical evidence, suggests a long‐term pain control role of this treatment. The spontaneous OA dog model has a key role in developing successful treatments for translational medicine. stem cells translational medicine 2018;7:819–828

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Section: Discussionsupporting

confidence: 91%

Intra-Articular Administration of Autologous Micro-Fragmented Adipose Tissue in Dogs with Spontaneous Osteoarthritis: Safety, Feasibility, and Clinical Outcomes

Zeira

Scaccia

Pettinari

et al. 2018

Stem Cells Translational Medicine

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“…This is in line with recent reports showing that dogs having mild lameness are less likely to improve. 38 Regarding the mechanism by which purified and microfragmented adipose tissue exerts its action within the joint, it has been speculated that adipocytes may play a mechanical role as a sort of shock absorber, protecting and lubricating the joint, while the therapeutic efficacy of adipose tissuederived stromal vascular fraction relies on angiogenic, antiinflammatory, immunomodulatory and regenerative effects. 8 Adipose stem cells in the form of adipose tissuederived stromal vascular fraction are multi-potential, contributing to chondroprotection and preventing the progression of osteoarthritis through a combination of secretory effects, direct engraftment and differentiation.…”

Section: Discussionmentioning

confidence: 99%

Evaluation of a Single Intra-Articular Injection of Autologous Adipose Tissue for the Treatment of Osteoarthritis: A Prospective Clinical Study in Dogs

Pavarotti

Hivernaud²,

Brincin

et al. 2020

Vet Comp Orthop Traumatol

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Objective The aim of this study was to investigate the safety, feasibility and clinical efficacy of a single intra-articular injection of autologous and purified micro-fragmented adipose tissue for the treatment of osteoarthritis (OA) in dogs. Study Design Twenty-one client-owned dogs with radiographically confirmed OA were recruited into this prospective study. Lameness and discomfort were evaluated by physical examination at day 0 and then 14, 30, 60 and 180 days after injection. Kinetic data and temporospatial parameters were obtained using a pressure-sensing walkway. Peak vertical force, vertical impulse and percentages of body weight distribution were determined. Owner perception data regarding their own dog's physical activity were also collected using the Canine Brief Pain Inventory. Results Radiographic scores for OA from days 0 to 180 were similar, except in two dogs. No major side effects were noted after injection. Lameness and Canine Brief Pain Inventory scores were significantly lower at all time points compared with day 0. Post-injection results demonstrated gradual improvement of kinetic data up to day 180 compared with pre-treatment values: vertical impulse (>2.25%), peak vertical force (>5.32%) and percentages of body weight distribution (>3.6%). In dogs with elbow OA, gait analysis values significantly increased at all time points compared with day 0. Conclusion Regenerative autologous adipose tissue injection therapy is a promising alternative to traditional analgesics treatment in patients with OA, associated with significant reductions in pain and lameness, delayed disease progression and improved quality of life.

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“…The represented breeds were domestic short hair (n=12) and domestic long hair (n=1). The cats were aged 60 months, weighed 5.4 ± 1.2 kg, had a BCS of 5 [4][5][6][7][8][9] and their height was 28 ± 3.6 cm. There were significant positive correlations between both the body weight and the BCS, and the sensory thresholds (SCC: 0.21 and 0.27; and P = 0.04 and 0.007, respectively), and significant negative correlation between the height of the cats and the sensory thresholds (SCC: -0.31; P = 0.001).…”

Section: Resultsmentioning

confidence: 99%

“…Despite the lack of a unanimously accepted characterization of chronic pain in cats, 6 as a matter of fact cats do suffer from clinical conditions, such as osteoarthritis (OA), 7 which in humans and dogs are known to cause maladaptive pain. [8][9][10] In an attempt to evaluate OA-related feline pain, Benito and colleagues 11 developed and validated a Feline Musculoskeletal Pain Index (FMPI), based on subjective assessments performed by the owner in the animals' natural environment.…”

Section: Introductionmentioning

confidence: 99%

Inter-rater and inter-device reliability of mechanical thresholds measurement with the Electronic von Frey Anaesthesiometer and the SMALGO in healthy cats

Adami

Lardone

Monticelli

2018

Journal of Feline Medicine and Surgery

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Objectives The aim of this study was to compare the Electronic von Frey Anaesthesiometer (EVF) and the Small Animal ALGOmeter (SMALGO), used to measure sensory thresholds in 13 healthy cats at both the stifle and the lumbosacral joint, in terms of inter-rater and inter-device reliability. Methods Two independent observers carried out the sets of measurements in a randomised order, with a 45 min interval between them, in each cat. The inter-rater and inter-device reliability were evaluated by calculating the inter-rater correlation coefficient (ICC) for each pair of measurements. The Bland–Altman method was used as an additional tool to assess the level of agreement between the two algometers. Results The mean ± SD sensory thresholds measured with the EVF were 311 ± 116 g and 378 ± 178 g for the stifle and for the lumbosacral junction, respectively, whereas those measured with the SMALGO were 391 ±172 g and 476 ± 172 g. The inter-rater reliability was fair (ICC >0.4) for each pair of measurements except those taken at the level of the stifle with the SMALGO, for which the level of agreement between observers A and B was poor (ICC = 0.01). The inter-device reliability was good (ICC = 0.73; P = 0.001). The repetition of the measurements affected reliability, as the thresholds obtained after the 45 min break were consistently lower than those measured during the first part of the trial ( P = 0.02). Conclusions and relevance The EVF and the SMALGO may be used interchangeably in cats, especially when the area to be tested is the lumbosacral joint. However, when the thresholds are measured at the stifle, the inter-observer reliability is better with the EVF than with the SMALGO. The reliability decreases when the measurements are repeated within a short time interval, suggesting a limited clinical applicability of quantitative sensory testing with both algometers in cats.

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Therapeutic response analysis in dogs with naturally occurring osteoarthritis

Cited by 17 publications

References 34 publications

Intra-Articular Administration of Autologous Micro-Fragmented Adipose Tissue in Dogs with Spontaneous Osteoarthritis: Safety, Feasibility, and Clinical Outcomes

Intra-Articular Administration of Autologous Micro-Fragmented Adipose Tissue in Dogs with Spontaneous Osteoarthritis: Safety, Feasibility, and Clinical Outcomes

Evaluation of a Single Intra-Articular Injection of Autologous Adipose Tissue for the Treatment of Osteoarthritis: A Prospective Clinical Study in Dogs

Inter-rater and inter-device reliability of mechanical thresholds measurement with the Electronic von Frey Anaesthesiometer and the SMALGO in healthy cats

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