Therapeutic role of columbianadin in human disorders: Medicinal importance, biological properties and analytical aspects

Patel, Dinesh Kumar

doi:10.1016/j.prmcm.2022.100212

Cited by 10 publications

(2 citation statements)

References 107 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Columbianadin is a natural compound found in certain plants, particularly in the genus Angelica, which includes Angelica keiskei Koidzumii and Angelica gigas Nakai. It is classified as a coumarin derivative, a type of organic compound commonly found in plants 12,13 . Columbianadin has been subject of interest in research due to its potential pharmacological properties.…”

Section: Introductionmentioning

confidence: 99%

“…Columbianadin has been subject of interest in research due to its potential pharmacological properties. Some studies have suggested that it may have anti-inflammatory, antioxidant, and anti-cancer properties [12][13][14][15] . However, further research is needed to fully understand its mechanisms of action and its potential applications in medicine.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Columbianadin ameliorates experimental acute reflux esophagitis in rats via suppression of NF-κB pathway

Wu,

Hussain,

Luo

2024

Acta Cir. Bras.

View full text Add to dashboard Cite

Purpose: Reflux esophagitis is a condition characterized by inflammation and irritation of the esophagus, resulting from the backflow of stomach acid and other gastric contents into the esophagus. Columbianadin is a coumarin derivative that exhibits antiinflammatory and antioxidant effects. In this study, we tried to scrutinize the protective effect of Columbianadin against acute reflux esophagitis in rats. Methods: RAW 264.7 cells were utilized to assess cell viability and measure the production of inflammatory parameters. The rats received anesthesia, and reflux esophagitis was induced via ligation of pylorus and fore stomach and corpus junction. Rats received the oral administration of Columbianadin (25, 50 and 100 mg/kg) and omeprazole (20 mg/kg). The gastric secretion volume, acidity, and pH were measured. Additionally, the levels of oxidative stress parameters, cytokines, and inflammatory markers were determined. At the end of the study, mRNA expression was assessed. Results: Columbianadin remarkably suppressed the cell viability and production of tumor necrosis factor-α (TNF-α), interleukin (IL)-1β, IL-6, cyclooxygenase-2 (COX-2), inducible nitric oxide synthase (iNOS), and prostaglandin (PGE2). Columbianadin treatment remarkably suppressed the secretion of gastric volume, total acidity and enhanced the pH level in the stomach. Columbianadin remarkably altered the level of hydrogen peroxidase, free iron, calcium, and plasma scavenging activity, sulfhydryl group; oxidative stress parameters like malonaldehyde, glutathione, superoxide dismutase, catalase, glutathione peroxidase; inflammatory cytokines viz., TNF-α, IL-6, IL-1β, IL-10, IL-17, and monocyte chemoattractant protein-1; inflammatory parameters including PGE 2 , iNOS, COX-2, and nuclear kappa B factor (NF-κB). Columbianadin remarkably (P < 0.001) suppressed the mRNA expression TNF-α, IL-6, IL-1β and plasminogen activator inhibitor-1. Conclusion:Columbianadin demonstrated a protective effect against acute reflux esophagitis via NF-κB pathway.

show abstract

Section: Introductionmentioning

confidence: 99%