Therapeutic role of natural agents in beta-thalassemia: A review

Kukreja, Aayush; Wadhwa, Neha; Tiwari, Archana

doi:10.1016/j.jopr.2013.10.002

Cited by 12 publications

(5 citation statements)

References 31 publications

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“…GA has been reported for its iron chelating properties which have been proved to be useful in the treatment of thalassemic patients. 33,34 It has also been reported for being an endogenous siderophore whose deficiency may lead to anemia and splenic overload in mice. 35 These reports may be correlated in this study wherein the CP induced anemia has been successfully ameliorated which can be attributed to the iron chelating properties of GA. Huang et al, 2011 in their study documented the association between the grade of platinum-based chemotherapy induced leukopenia and the clinical outcome of patients with metastatic non-small cell lung cancer patients amongst which neutropenia and monocytopenia was found to be more prominent.…”

Section: Discussionmentioning

confidence: 99%

Ameliorative effects of Gentisic acid on carboplatin induced hematological toxicities in Wistar Rats

Pujari¹,

Bandawane²

2019

IJPTR

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Hematological toxicity is a frequent and severe adverse effect of carboplatin chemotherapy, limiting its clinical use despite being one of the most potent anticancer agents. The present study was designed to evaluate the protective effects of a naturally occurring plant phenolic acids i.e. gentisic acid (2,5 dihyroxybenzoic acid) against carboplatin induced hematological toxicities in wistar rats. Exposure to carboplatin at a dose of 35 mg/kg caused significant decrease in hematological parameters of blood such as red blood cells, total leucocytes, platelets, neutrophills, basophills, lymphocytes and moncytes counts whereas increase in eosiphill counts rat blood indicating severe pancytopenia. Administration of gentisic acid at 10, 30 and 100 for 14 days resulted in a significant amelioration of altered blood parameters in a dose dependent manner indicating its potential as a protective agent for the prevention and amelioration of caboplatin induced hematological toxicities.

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Section: Discussionmentioning

confidence: 99%

Ameliorative effects of Gentisic acid on carboplatin induced hematological toxicities in Wistar Rats

Pujari¹,

Bandawane²

2019

IJPTR

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“…This means that resveratrol's anti-MERS and anti-SARS-CoV2 properties can be explored further. It has been revealed that the antioxidant polyphenol resveratrol protects against free radical damage in disorders such as cancer, diabetes, heart disease, neurological disease, and microbial infection [ 76 , 77 ].…”

Section: Medicinal Plant Candidatesmentioning

confidence: 99%

Natural Products as a Potential Source of Promising Therapeutics for COVID‐19 and Viral Diseases

Bafandeh

Khodadadi

Ganbarov

et al. 2023

Evidence-Based Complementary and Alternative Medicine

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Background. A global pandemic has recently been observed due to the new coronavirus disease, caused by SARS-CoV-2. Since there are currently no antiviral medicines to combat the highly contagious and lethal COVID-19 infection, identifying natural sources that can either be viricidal or boost the immune system and aid in the fight against the disease can be an essential therapeutic support. Methods. This review was conducted based on published papers related to the herbal therapy of COVID-19 by search on databases including PubMed and Scopus with herbal, COVID-19, SARS-CoV-2, and therapy keywords. Results. To combat this condition, people may benefit from the therapeutic properties of medicinal plants, such as increasing their immune system or providing an antiviral impact. As a result, SARS-CoV-2 infection death rates can be reduced. Various traditional medicinal plants and their bioactive components, such as COVID-19, are summarized in this article to assist in gathering and debating techniques for combating microbial diseases in general and boosting our immune system in particular. Conclusion. The immune system benefits from natural products and many of these play a role in activating antibody creation, maturation of immune cells, and stimulation of innate and adaptive immune responses. The lack of particular antivirals for SARS-CoV-2 means that apitherapy might be a viable option for reducing the hazards associated with COVID-19 in the absence of specific antivirals.

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“…Curcuminoids have been shown to bind in vitro and alleviate toxicity in thalassemic mice [31,32]. T h e i r o n c h e l a t i n g a c t i v i t y o f A f r i c a n w a l n u t (Tetracarpidium conophorum) and wheat grass (Triticum aestivum) extracts have been studied and the results suggest this may have potential for iron overload in thalassaemia patients [33][34][35]. The African walnut contains a number of phenolic compounds which are believed to chelate to iron or copper [34].…”

Section: Iron Chelatorsmentioning

confidence: 99%

“…The active chelators in wheat grass appear to be derivatives of mugineic acid, 3-hydroxy-mugineic acid and 2′deoxy-mugineic acid [35]. More understanding of the role that chelation plays is needed as these natural compounds also affect gene control of foetal haemoglobin which helps thalassaemia patients [33].…”

Section: Iron Chelatorsmentioning

confidence: 99%

Chelators in Iron and Copper Toxicity

et al. 2016

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Purpose of ReviewChelation therapy is used for diseases causing an imbalance of iron levels (for example haemochromatosis and thalassaemia) or copper levels (for example Menkes' and Wilson's diseases). Currently, most pharmaceutical chelators are relatively simple but often have side effects. Some have been taken off the market.This review attempts to find theory and knowledge required to design or find better chelators. Recent FindingsRecent research attempting to understand the biological mechanisms of protection against iron and copper toxicity is reviewed. Understanding of molecular mechanisms behind normal iron/copper regulation may lead to the design of more sophisticated chelators. The theory of metal ion toxicity explains why some chelators, such as EDTA, which chelate metal ions in a way which exposes the ion to the surrounding environment are shown to be unsuitable except as a means of killing cancer cells.The Lewis theory of acids and bases suggests which amino acids favour the attachment of the hard/intermediate ions Fe . Non-polar amino acids will chelate the ion in a position not in contact with the surrounding cellular environment. The conclusion is that only the soft ion binding cysteine and methionine appear as suitable chelators. Clearly, nature has developed proteins which are less restricted.Recent research on naturally produced chelators such as siderophores and phytochemicals show some promise as pharmaceuticals. SummaryAlthough an understanding of natural mechanisms of Fe/Cu regulation continues to increase, the pharmaceutical chelators for metal overload diseases remain simple non-protein molecules. Natural and synthetic alternatives have been studied but require further research before being accepted.

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Therapeutic role of natural agents in beta-thalassemia: A review

Cited by 12 publications

References 31 publications

Ameliorative effects of Gentisic acid on carboplatin induced hematological toxicities in Wistar Rats

Ameliorative effects of Gentisic acid on carboplatin induced hematological toxicities in Wistar Rats

Natural Products as a Potential Source of Promising Therapeutics for COVID‐19 and Viral Diseases

Chelators in Iron and Copper Toxicity

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