2022
DOI: 10.5530/fra.2022.1.1
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Therapeutic Role of the Liver X Receptor in Modulation of Metabolic Diseases and Future Scenarios

Abstract: Liver X receptors (LXRs) are part of the nuclear receptor superfamily and are cholesteroldetecting receptors. LXRs are commonly found in two isoforms: LXR and LXR. LXRs were initially identified as orphan receptors from a rat cDNA library using an oligonucleotide probe. The regulatory activities of LXR in obesity are the subject of this review. LXRs directly operate on numerous target genes such as ABCA1, ABCG1, ABCG8, GLUT4, and other rate-limiting enzymes such as PEPCK, G6P, and F6P, and so play an important… Show more

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