Therapeutic SHPRH-146aa encoded by circ-SHPRH dynamically upregulates P21 to inhibit CDKs in neuroblastoma

Chang, Saishuo; Ren, Dong; Zhang, Li; Liu, Shan; Yang, Wei; Cheng, Haiyan; Zhang, Xuexi; Hong, Enyu; Geng, Di; Wang, Yadi; Chen, Chenghao; Zhang, Jie; Shi, Tieliu; Guo, Yongli; Ni, Xin; Wang, Huanmin; Jin, Yaqiong

doi:10.1016/j.canlet.2024.217120

Cancer Letters

2024

DOI: 10.1016/j.canlet.2024.217120

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Therapeutic SHPRH-146aa encoded by circ-SHPRH dynamically upregulates P21 to inhibit CDKs in neuroblastoma

Saishuo Chang,

Dong Ren,

Li Zhang

et al.

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CircRNA and lncRNA-encoded peptide in diseases, an update review

Yi,

Feng,

Lan

et al. 2024

Mol Cancer

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Non-coding RNAs (ncRNAs), including circular RNAs (circRNAs) and long non-coding RNAs (lncRNAs), are unique RNA molecules widely identified in the eukaryotic genome. Their dysregulation has been discovered and played key roles in the pathogenesis of numerous diseases, including various cancers. Previously considered devoid of protein-coding ability, recent research has revealed that a small number of open reading frames (ORFs) within these ncRNAs endow them with the potential for protein coding. These ncRNAs-derived peptides or proteins have been proven to regulate various physiological and pathological processes through diverse mechanisms. Their emerging roles in disease diagnosis and targeted therapy underscore their potential utility in clinical settings. This comprehensive review aims to provide a systematic overview of proteins or peptides encoded by lncRNAs and circRNAs, elucidate their production and functional mechanisms, and explore their promising applications in cancer diagnosis, disease prediction, and targeted therapy.

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CircRNA and lncRNA-encoded peptide in diseases, an update review

Yi,

Feng,

Lan

et al. 2024

Mol Cancer

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show abstract

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Therapeutic SHPRH-146aa encoded by circ-SHPRH dynamically upregulates P21 to inhibit CDKs in neuroblastoma

Cited by 1 publication

References 86 publications

CircRNA and lncRNA-encoded peptide in diseases, an update review

CircRNA and lncRNA-encoded peptide in diseases, an update review

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