Therapeutic strategies for glaucoma and optic neuropathies

Lo, Jung; Mehta, Kamakshi; Dhillon, Armaan; Huang, Yu-Kai; Luo, Ziming; Nam, Mi-Hyun; Al Diri, Issam; Chang, Kun-Che

doi:10.1016/j.mam.2023.101219

Cited by 2 publications

(1 citation statement)

References 174 publications

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“…However, it is important to note that not all the individuals with a high IOP develop glaucoma, and, conversely, glaucoma can occur in those with a normal IOP, suggesting that other factors play a crucial role [365]. However, existing treatment paradigms focus on reducing the intraocular pressure, mainly through the daily use of eye drops, sometimes associated with side effects or invasive surgical interventions [366,367]. The frequent inadequacy of ocular pressure-lowering approaches, substantial rates of treatment non-adherence affecting 30-70% of patients, and resulting financial burdens indicate the need for long-lasting, neuroprotective therapies.…”

Section: Glaucomamentioning

confidence: 99%

The Healthy and Diseased Retina Seen through Neuron–Glia Interactions

Tempone,

Borges-Martins,

César

et al. 2024

IJMS

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The retina is the sensory tissue responsible for the first stages of visual processing, with a conserved anatomy and functional architecture among vertebrates. To date, retinal eye diseases, such as diabetic retinopathy, age-related macular degeneration, retinitis pigmentosa, glaucoma, and others, affect nearly 170 million people worldwide, resulting in vision loss and blindness. To tackle retinal disorders, the developing retina has been explored as a versatile model to study intercellular signaling, as it presents a broad neurochemical repertoire that has been approached in the last decades in terms of signaling and diseases. Retina, dissociated and arranged as typical cultures, as mixed or neuron- and glia-enriched, and/or organized as neurospheres and/or as organoids, are valuable to understand both neuronal and glial compartments, which have contributed to revealing roles and mechanisms between transmitter systems as well as antioxidants, trophic factors, and extracellular matrix proteins. Overall, contributions in understanding neurogenesis, tissue development, differentiation, connectivity, plasticity, and cell death are widely described. A complete access to the genome of several vertebrates, as well as the recent transcriptome at the single cell level at different stages of development, also anticipates future advances in providing cues to target blinding diseases or retinal dysfunctions.

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Section: Glaucomamentioning

confidence: 99%

The Healthy and Diseased Retina Seen through Neuron–Glia Interactions

Tempone,

Borges-Martins,

César

et al. 2024

IJMS

View full text Add to dashboard Cite

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Glaucoma and dietary links: insights from high-salt intake, the Mediterranean diet, and specific nutrients

Yang,

Zhou,

Hong

2024

Front. Nutr.

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Glaucoma, a prevalent and potentially blinding eye disease, is linked to a variety of factors, including elevated intraocular pressure, optic nerve damage, and oxidative stress. In recent years, dietary habits, as a controllable lifestyle factor, have received increasing attention in the prevention and treatment of glaucoma. The purpose of this review was to investigate the effects of dietary factors on glaucoma, with a particular emphasis on two common dietary patterns: the high-salt diet and the Mediterranean diet. In addition, we investigated the association between many particular nutrients (including omega-3 fatty acids, vitamins, caffeine, and minerals) and glaucoma to fully assess the potential involvement of dietary variables in glaucoma pathogenesis, prevention, and treatment. This article reveals the importance of dietary components in glaucoma prevention and explores prospective possibilities for future research by conducting a comprehensive review of previous scientific studies.

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Therapeutic strategies for glaucoma and optic neuropathies

Cited by 2 publications

References 174 publications

The Healthy and Diseased Retina Seen through Neuron–Glia Interactions

The Healthy and Diseased Retina Seen through Neuron–Glia Interactions

Glaucoma and dietary links: insights from high-salt intake, the Mediterranean diet, and specific nutrients

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