Therapeutic strategies for oral lichen planus: State of the art and new insights

Didona, Dario; Caposiena, Raffaele Dante; Santos, Antonio Manuel Sequeira; Solimani, Farzan; Hertl, Michael

doi:10.3389/fmed.2022.997190

Cited by 47 publications

(42 citation statements)

References 88 publications

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“…Oral lichen planus (OLP) is a chronic inflammatory, mucocutaneous, autoimmune disease which is quite common in the female oral mucosa. Erosive OLP is characterized by ulceration and erosion in oral mucosa and causes severe pain in patients [ 2 ]. The recommended topical therapies for erosive OLP are topical corticosteroids, tacrolimus and photodynamic therapy.…”

Section: Introductionmentioning

confidence: 99%

In Vitro Cell Proliferation and Migration Properties of Oral Mucosal Fibroblasts: A Comparative Study on the Effects of Cord Blood- and Peripheral Blood-Platelet Lysate

Azmi

Yahya

Azhar

et al. 2023

IJMS

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Cord blood-platelet lysate (CB-PL), containing growth factors such as a platelet-derived growth factor, has a similar efficacy to peripheral blood-platelet lysate (PB-PL) in initiating cell growth and differentiation, which makes it a unique alternative to be implemented into oral ulceration healing. This research study aimed to compare the effectiveness of CB-PL and PB-PL in promoting oral wound closure in vitro. Alamar blue assay was used to determine the optimal concentration of CB-PL and PB-PL in enhancing the proliferation of human oral mucosal fibroblasts (HOMF). The percentage of wound closure was measured using the wound-healing assay for CB-PL and PB-PL at the optimal concentration of 1.25% and 0.3125%, respectively. The gene expressions of cell phenotypic makers (Col. I, Col. III, elastin and fibronectin) were determined via qRT-PCR. The concentrations of PDGF-BB were quantified using ELISA. We found that CB-PL was as effective as PB-PL in promoting wound-healing and both PL were more effective compared to the control (CTRL) group in accelerating the cell migration in the wound-healing assay. The gene expressions of Col. III and fibronectin were significantly higher in PB-PL compared to CB-PL. The PDGF-BB concentration of PB-PL was the highest and it decreased after the wound closed on day 3. Therefore, we concluded that PL from both sources can be a beneficial treatment for wound-healing, but PB-PL showed the most promising wound-healing properties in this study.

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Section: Introductionmentioning

confidence: 99%

In Vitro Cell Proliferation and Migration Properties of Oral Mucosal Fibroblasts: A Comparative Study on the Effects of Cord Blood- and Peripheral Blood-Platelet Lysate

Azmi

Yahya

Azhar

et al. 2023

IJMS

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“…The 2nd-ranked drug was Vitinoin, the generic name of which is tretinoin, which has been included in clinical trials and has demonstrated potential improvements in the clinical treatments pertaining to LP [38,39]. Dexamethasone is a steroid-based drug ranked 16th and has demonstrated good clinical outcomes associated with OLP [40][41][42][43]. In Supplementary Table 1_C, we provide enrichment analysis results pertaining to drug terms within DSigDB.…”

Section: Tablementioning

confidence: 99%

GENEvaRX: A Novel AI-Driven Method and Web Tool Can Identify Critical Genes and Effective Drugs for Lichen Planus

Turki

Taguchi

2023

Preprint

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Lichen planus (LP) is an autoimmune disorder diagnosed based on physical symptoms and lab tests. Examples of symptoms include flat bumps, and itchy and purplish skin, while lab tests include a shave biopsy of the lesion. When the pathology report shows consistency with LP and is negative for potential triggers for an allergy test and hepatitis C, a dermatologist typically prescribes corticosteroid in the form of pills or injection into the lesion to treat the symptoms. To understand the molecular mechanism of the disease and thereby overcome issues associated with disease treatment, there is a need to identify potential effective drugs, drug targets, and therapeutic targets associated the LP. Hence, we propose a novel computational framework based on new constrained optimization to support vector machines coupled with enrichment analysis. First, we downloaded three gene expression datasets (GSE63741, GSE193351, GSE52130) pertaining to healthy and LP patients from the gene expression omnibus (GEO) database. We then processed each dataset and entered it into our computational framework to select important genes. Finally, we performed enrichment analysis of selected genes, reporting the following results. Our methods outperformed baseline methods in terms of identifying disease and skin tissue. Moreover, we report 5 drugs (including, dexamethasone, retinoic acid, and quercetin), 45 unique genes (including PSMB8, KRT31, KRT16, KRT19, KRT17, COL3A1, LCE2D, LCE2A), and 23 unique TFs (including NFKB1, STAT1, STAT3) reportedly related to LP pathogenesis, treatments, and therapeutic targets. Our methods are publicly available in the GENEvaRX web server at https://aibio.shinyapps.io/GENEvaRX/.

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“…The pharmacological therapeutic modalities used in the treatment of OLP include corticosteroids (topical, intralesional, and systemic steroids), Immunosuppressants (tacrolimus, azathioprine, cyclosporin, and mycophenolate mofetil,), immunomodulators (levamisole and thalidomide), and retinoids. Various non-pharmacological regimens, such as Light amplification by stimulated emission of radiation (LASER) therapy, photodynamic therapy, and Psoralen plus ultraviolet-A radiation (PUVA) therapy are also used in OLP treatment [ 19 , 22 ]. A range of alternative therapies, such as topical aloe vera, oral curcuminoids, lycopene, hyaluronic acid, Bacillus Calmette-Guerin Polysaccharide nucleic acid (BCG-PSN), purslane extract, and ignatia have also exhibited promising results in the management of OLP [ 23 ].…”

Section: Introductionmentioning

confidence: 99%

Vitamin D in the Treatment of Oral Lichen Planus: A Systematic Review

Saeed

Choudhury²,

Ahmad

et al. 2022

Biomedicines

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Oral lichen planus (OLP) is a chronic mucocutaneous condition that affects up to 2% of the general population, and typically presents with long-standing, non-responsive lesions, with episodes of exacerbation and remissions. The etiopathogenesis of OLP is still unclear, although, it has been postulated that it is most likely a T-cell-mediated condition of an unknown antigen. The treatment remains a challenge with no defined treatment strategy. Vitamin D has anti-inflammatory and immunomodulatory properties, along with its regulatory effect on keratinocyte proliferation and differentiation; thus, suggesting its possible role in the treatment of OLP. This systematic review aims to evaluate the therapeutic role of vitamin D in OLP treatment. We searched PubMed/MEDLINE, and Google scholar search engines for studies evaluating vitamin D as a treatment modality in OLP from January 2000 to August 2022. Articles were searched with the combination of Medical Subject Heading (MeSH) terms. A web platform for visualizing risk-of-bias assessment was used in this review, and descriptive statistics were calculated. Out of the seventeen retrieved studies, five articles meeting the inclusion criteria were considered in this systematic review. All the included studies demonstrated significant amelioration in the OLP symptoms in patients who were given vitamin D supplements as an adjuvant to the conventional steroid therapy and or placebo. This systematic review signifies the role of vitamin D as adjuvant therapy for OLP. However, more studies with larger sample size are required to validate these results.

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Therapeutic strategies for oral lichen planus: State of the art and new insights

Cited by 47 publications

References 88 publications

In Vitro Cell Proliferation and Migration Properties of Oral Mucosal Fibroblasts: A Comparative Study on the Effects of Cord Blood- and Peripheral Blood-Platelet Lysate

In Vitro Cell Proliferation and Migration Properties of Oral Mucosal Fibroblasts: A Comparative Study on the Effects of Cord Blood- and Peripheral Blood-Platelet Lysate

GENEvaRX: A Novel AI-Driven Method and Web Tool Can Identify Critical Genes and Effective Drugs for Lichen Planus

Vitamin D in the Treatment of Oral Lichen Planus: A Systematic Review

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