Therapeutic strategies for rheumatic diseases and disorders: targeting redox imbalance and oxidative stress

Islam, Muhammad Torequl; Sarkar, Chandan Kumar; Hossain, Rajib; Bhuia, Md. Shimul; Mardare, Ileana; Kulbayeva, Marzhan; Ydyrys, Alibek; Calina, Daniela; Habtemariam, Solomon; Kieliszek, Marek; Sharifi‐Rad, Javad; Cho, William C.

doi:10.1016/j.biopha.2023.114900

Cited by 22 publications

(13 citation statements)

References 103 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…They act as endogenous antioxidant defense systems, which clear ROS activity and accumulation in cells and maintain redox balance. [84][85][86] Phytochemicals which capable of elevating the activities of these antioxidant enzymes are a prominent target for anticancer drug therapy.…”

Section: Inhibition Of Oxidative Stressmentioning

confidence: 99%

Efficacy of Rotundic Acid and Its Derivatives as Promising Natural Anticancer Triterpenoids: A Literature‐Based Study

Bhuia,

Chowdhury,

Sonia

et al. 2024

Chemistry & Biodiversity

Self Cite

View full text Add to dashboard Cite

Rotundic acid (RA) is a naturally occurring pentacyclic triterpene with a multitude of pharmacological activities. The primary emphasis of this study is on summarizing the anticancer properties with the underlying mechanisms of RA and its derivatives, as well as the pharmacokinetic features. Data was collected (up to date as of November 10, 2023) from various reliable and authentic literatures by searching in different academic search engines, including PubMed, Springer Link, Scopus, Wiley Online, Web of Science, ScienceDirect, and Google Scholar. The findings imply that RA and its synthetic derivatives possess promising anti‐cancer properties against breast, colorectal, liver, and cervical cancers in various preclinical pharmacological test systems. The results also indicate that RA and its derivatives demonstrated anticancer effects via a number of cellular mechanisms, including apoptotic cell death, inhibition of oxidative stress, anti‐inflammatory effect, cytotoxicity, cell cycle arrest, anti‐proliferative effect, anti‐angiogenic effect, and inhibition of cancer cell migration and invasion. It has been proposed that RA and its derived compounds have the capability to serve as a hopeful chemotherapeutic agent, so further extensive clinical research is necessary.

show abstract

Section: Inhibition Of Oxidative Stressmentioning

confidence: 99%

Efficacy of Rotundic Acid and Its Derivatives as Promising Natural Anticancer Triterpenoids: A Literature‐Based Study

Bhuia,

Chowdhury,

Sonia

et al. 2024

Chemistry & Biodiversity

Self Cite

View full text Add to dashboard Cite

show abstract

“…Reactive species oxidize cellular biomolecules, leading to DNA damage ( 93 ). Therefore, reducing oxidative stress in RA is an effective therapeutic strategy ( 94 ). Physiological antioxidant enzymes such as superoxide dismutase (SOD), glutathione (GSH), and peroxiredoxins counteract the possible damaging effects of these reactive species by scavenging or neutralizing free radicals and oxidizing substances.…”

Section: Effects Of Tea Against Op Oa and Ramentioning

confidence: 99%

Potential mechanism of tea for treating osteoporosis, osteoarthritis, and rheumatoid arthritis

Xie,

Fu,

Gou

et al. 2024

Front. Med.

View full text Add to dashboard Cite

Osteoporosis (OP), osteoarthritis (OA), and rheumatoid arthritis (RA) are common bone and joint diseases with a high incidence and long duration. Thus, these conditions can affect the lives of middle-aged and elderly people. Tea drinking is a traditional lifestyle in China, and the long-term intake of tea and its active ingredients is beneficial to human health. However, the mechanisms of action of tea and its active ingredients against OP, OA, and RA are not completely elucidated. This study aimed to assess the therapeutic role and related mechanisms of tea and its active ingredients in OP, OA, and RA. Moreover, it expanded the potential mechanisms of tea efficacy based on network pharmacology and molecular docking. Results showed that tea has potential anti-COX properties and hormone-like effects. Compared with a single component, different tea components synergize or antagonize each other, thereby resulting in a more evident dual effect. In conclusion, tea has great potential in the medical and healthcare fields. Nevertheless, further research on the composition, proportion, and synergistic mechanism of several tea components should be performed.

show abstract

“…As consequences of biochemical reactions or as a result of exogenous factors, ROS like singlet oxygen, superoxide anion, hydroxyl radical, and hydrogen peroxide are frequently produced [50,51] . By reacting with almost all of the molecules present in living cells, including DNA, these reactive species cause oxidative damage [52,53] . Elevated levels of intrinsic or extrinsic free radicals and high levels of lipid peroxides, which are the etiology of several degenerative conditions including atherosclerosis, cancer, diabetes, Alzheimer's disease, cataracts, aging, and so on, are produced by excess ROS if the antioxidant system is not able to remove them [50,54] .…”

Section: Traditional Usesmentioning

confidence: 99%

“…[50,51] By reacting with almost all of the molecules present in living cells, including DNA, these reactive species cause oxidative damage. [52,53] Elevated levels of intrinsic or extrinsic free radicals and high levels of lipid peroxides, which are the etiology of several degenerative conditions including atherosclerosis, cancer, diabetes, Alzheimer's disease, cataracts, aging, and so on, are produced by excess ROS if the antioxidant system is not able to remove them. [50,54] Consequently, to maintain the antioxidant system, different synthetic antioxidants including butylated hydroxytoluene (BHT), butylated hydroxyanisole (BHA), and propyl gallate (PG) have been used, but these are not safe, accessible, and affordable.…”

Section: Antioxidant Activitymentioning

confidence: 99%

Mikania micranthaKunth: An Ethnopharmacological Treasure Trove of Therapeutic Potential

Ali Khan,

El‐Kersh,

Islam

et al. 2023

Chemistry & Biodiversity

Self Cite

View full text Add to dashboard Cite

Mikania micrantha is utilized as a therapeutic for the treatment of various human ailments including insect bites, rashes and itches of skin, chicken pox, healing of sores and wounds, colds and fever, nausea, jaundice, rheumatism, and respiratory ailments. This study aimed at summarizing the traditional uses, phytochemical profile, and biological activities of M. micrantha based on obtainable information screened from different databases. The results suggest that fresh leaves and whole plant are frequently used in folk medicine. The plant contains more than 150 different phytochemicals under the following groups: essential oils, phenolics and flavonoids, terpenes, terpene lactones, glycosides, and sulfated flavonoids. It contains carbohydrates and micronutrients including vitamins and major and trace minerals. M. micrantha possesses antioxidant, anti‐inflammatory, anti‐microbial, anti‐dermatophytic, anti‐protozoal, anthelmintic, cytotoxic, anxiolytic, anti‐diabetic, lipid‐lowering and antidiabetic, spasmolytic, memory‐enhancing, wound‐healing, anti‐aging, and thrombolytic activities. No clinical studies have been reported to date. M. micrantha might be one of the potential sources of phytotherapeutic compounds against diverse ailments in humans. Studies are required to confirm its safety profile in experimental animals prior to initiating clinical trials. Moreover, adequate investigation is also crucial to clarify exact mechanism of action for each biological effect.

show abstract

Therapeutic strategies for rheumatic diseases and disorders: targeting redox imbalance and oxidative stress

Cited by 22 publications

References 103 publications

Efficacy of Rotundic Acid and Its Derivatives as Promising Natural Anticancer Triterpenoids: A Literature‐Based Study

Efficacy of Rotundic Acid and Its Derivatives as Promising Natural Anticancer Triterpenoids: A Literature‐Based Study

Potential mechanism of tea for treating osteoporosis, osteoarthritis, and rheumatoid arthritis

Mikania micranthaKunth: An Ethnopharmacological Treasure Trove of Therapeutic Potential

Contact Info

Product

Resources

About