Therapeutic targeting of PLK1 in TERT promoter‐mutant hepatocellular carcinoma
Qin Tang,
Guanghui Hu,
Ye Sang
et al.
Abstract:BackgroundHotspot mutations in the promoter of telomerase reverse transcriptase (TERT) gene are the most common genetic variants in hepatocellular carcinoma (HCC) and associated with poor prognosis of the disease. However, no drug was currently approved for treating TERT promoter mutation positive HCC patients. Here, we aim to explore the potential therapeutic strategy for targeting TERT promoter mutation in HCC.MethodsThe Liver Cancer Model Repository database was used for screening potential drugs to selecti… Show more
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