Therapeutic Targets and Drug Leads for Reproductive Health

Premrajan, Punya; Variyar, E. Jayadevi

doi:10.1007/978-981-99-9183-9_18

Drugs From Nature: Targets, Assay Systems and Leads 2024

DOI: 10.1007/978-981-99-9183-9_18

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Therapeutic Targets and Drug Leads for Reproductive Health

Punya Premrajan,

E. Jayadevi Variyar

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2024

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Apigenin as a Promising Agent for Enhancing Female Reproductive Function and Treating Associated Disorders

Sirotkin,

Harrath

2024

Biomedicines

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Apigenin is an organic flavonoid abundant in some plants such as parsley, chamomile, or celery. Recently, it has been investigated for several of its pharmacological characteristics, such as its ability to act as an antioxidant, reduce inflammation, and inhibit the growth of cancer cells. The purpose of this review is to provide a summary of the existing knowledge regarding the effects of apigenin on female reproductive systems and its dysfunctions. Apigenin can influence reproductive processes by regulating multiple biological events, including oxidative processes, cell proliferation, apoptosis, cell renewal and viability, ovarian blood supply, and the release of reproductive hormones. It could stimulate ovarian folliculogenesis, as well as ovarian and embryonal cell proliferation and viability, which can lead to an increase in fertility and influence the release of reproductive hormones, which may exert its effects on female reproductive health. Furthermore, apigenin could inhibit the activities of ovarian cancer cells and alleviate the pathological changes in the female reproductive system caused by environmental pollutants, harmful medications, cancer, polycystic ovarian syndrome, ischemia, as well as endometriosis. Therefore, apigenin may have potential as a biostimulator for female reproductive processes and as a therapeutic agent for certain reproductive diseases.

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Apigenin as a Promising Agent for Enhancing Female Reproductive Function and Treating Associated Disorders

Sirotkin,

Harrath

2024

Biomedicines

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Therapeutic Targets and Drug Leads for Reproductive Health

Cited by 1 publication

References 197 publications

Apigenin as a Promising Agent for Enhancing Female Reproductive Function and Treating Associated Disorders

Apigenin as a Promising Agent for Enhancing Female Reproductive Function and Treating Associated Disorders

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