Therapeutic use of caffeine in dermatology: A literature review

Visconti, Michael J.; Haidari, Wasim; Feldman, Steven R.

doi:10.4103/jdds.jdds_52_19

Cited by 12 publications

(13 citation statements)

References 36 publications

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“…In the cosmetic field, the application of caffeine in topical cosmetic products proved to prevent excessive fat accumulations in the skin, promote lymphatic drainage, and protect the skin from photodamage [ 52 ]. Caffeine has been highly reported to enhance the beneficial properties of dermatologic products due to its antioxidant and phosphodiesterase inhibitory effects, as well as being a cosmetic and nutraceutical ingredient [ 53 ]. Another interesting application of caffeine that has been reported is as a biocide, specifically against decaying fungi and termites in wood protection [ 54 ], and it has proved to be an eco-friendly alternative to the artificial biocidal agent.…”

Section: Resultsmentioning

confidence: 99%

Bioactive Compounds and Antioxidant Activity from Spent Coffee Grounds as a Powerful Approach for Its Valorization

2022

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Coffee is one of the world’s most popular beverages, and its consumption generates copious amounts of waste. The most relevant by-product of the coffee industry is the spent coffee grounds, with 6 million tons being produced worldwide per year. Although generally treated as waste, spent coffee grounds are a rich source of several bioactive compounds with applications in diverse industrial fields. The present work aimed at the analysis of spent coffee grounds from different geographical origins (Guatemala, Colombia, Brazil, Timor, and Ethiopia) for the identification of bioactive compounds with industrial interest. For this purpose, the identification and quantification of the bioactive compounds responsible for the antioxidant activity attributed to the spent coffee grounds were attempted using miniaturized solid-phase extraction (µ-SPEed), combined with ultrahigh-performance liquid chromatography with photodiode array detection (UHPLC-PDA). After validation of the µ-SPEed/UHPLC-PDA method, this allowed us to conclude that caffeine and 5-caffeoylquinic acid (5-CQA) are the most abundant bioactive compounds in all samples studied. The total phenolic content (TPC) and antioxidant activity are highest in Brazilian samples. The results obtained show that spent coffee grounds are a rich source of bioactive compounds, supporting its bioprospection based on the circular economy concept closing the loop of the coffee value chain, toward the valorization of coffee by-products.

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Section: Resultsmentioning

confidence: 99%

Bioactive Compounds and Antioxidant Activity from Spent Coffee Grounds as a Powerful Approach for Its Valorization

2022

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“…Cyclic adenosine monophosphate accumulation in the tissues is caused by phosphodiesterase (PDE) enzyme and is inhibited by this alkaloid (Barcelos et al, 2014). The body cells are secured against harm from certain substance responses, including oxidation of cancer prevention agent (Visconti et al 2020). Cell antioxidating activity of caffeine is connected to the rummaging of hydroxyl (OH) radical (Barrea et al, 2018).…”

Section: Caffeinementioning

confidence: 99%

A review on the important phytochemicals and their role in psoriasis

Pandey

Shukla

Dubey

et al. 2021

JANS

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Psoriasis may emerge at any stage of life irrespective of age, sex or geographic location. It is identified as a chronic immune-linked inflammatory skin disease that affects all human races. Psoriasis is often more Caucasian than non-Caucasian groups of human races and in geographic areas, like higher latitudes and Western countries. Therefore, attention should be paid to both genetic and environmental causes of psoriasis. Natural products have significantly contributed and encouraged the advances in skin disease treatment like psoriasis. The maximum number of phytochemicals is now being used worldwide, including various plants, herbs, and formulations. In addition, some phytochemicals like psoralen, aloe-emodin, curcumin etc. have also been isolated in pure form and have also shown their efficacy in the management of psoriasis. The presence of such phytochemicals confirms the effectiveness of few herbal therapies. This paper reviews some of the promising phytochemicals and their potential molecular target sites and mechanism of action, which may aid in designing and producing more precise and selective antipsoriatic agents. Exploring and recognizing phytochemicals as to how they function will facilitate more site-specific delivery methods for psoriasis care.

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“…At therapeutic doses of caffeine, the cerebral vessels are narrowed, which explains the beneficial effect of this drug at migraines. Caffeine stimulates skeletal muscle contraction through both central (via the CNS) and direct effects [16,17].…”

Section: ðàä³îëîã³÷íà ôàðìàêîëîã³ÿmentioning

confidence: 99%

“…Finally, adenosine has vasodilatory properties, inhibits renin release and platelet aggregation in vitro. Caffeine blocks this action [5,6,16,17].…”

Section: ðàä³îëîã³÷íà ôàðìàêîëîã³ÿmentioning

confidence: 99%

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Drugs of Radiological Pharmacology. Reprofiling: Caffeine

Kolotilov

2020

RDRT

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Caffeine (C8H10N4O2) is a purine alkaloid, colorless or white bitter crystals. It is a psychostimulant found in plants such as coffee, tea, cocoa, Paraguayan holly (mate), guarana, cola and others. The plant-based alkaloids related to caffeine are theobromine and theophylline. The fatal acute oral dose of caffeine for humans is estimated at 10-14 g (150-200 mg/kg body weight). As part of the reprofiling of drugs, caffeine is a means of oncological and radiological pharmacology. Caffeine reduces the risk of skin cancer and melanoma, colorectal cancer developing. Depending on the dose, caffeine has a radioprotective effect, increases the sensitivity of tumor cells to ionizing radiation (the radiosensitizing effects of caffeine are associated with inhibition of the activity of protein kinases), enhances the antitumor effect of chemotherapy drugs, especially agents that damage DNA (possibly, it can help in overcoming natural drug resistance), has protective action against cytogenotoxicity caused by vinblastine.

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Therapeutic use of caffeine in dermatology: A literature review

Cited by 12 publications

References 36 publications

Bioactive Compounds and Antioxidant Activity from Spent Coffee Grounds as a Powerful Approach for Its Valorization

Bioactive Compounds and Antioxidant Activity from Spent Coffee Grounds as a Powerful Approach for Its Valorization

A review on the important phytochemicals and their role in psoriasis

Drugs of Radiological Pharmacology. Reprofiling: Caffeine

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