Therapeutic Use of Soluble Fas Ligand Ameliorates Acute and Recurrent Herpetic Stromal Keratitis in Mice

Rogge, Megan; Yin, Xuewei; Godfrey, Lisa; Lakireddy, Priya; Potter, Chloe; Rosso, Chelsea R. Del; Stuart, Patrick M.

doi:10.1167/iovs.15-16588

Cited by 13 publications

(11 citation statements)

References 48 publications

(98 reference statements)

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“…It is possible that immune control mediated via sFas-L contributes to the moderate disease phenotype by preventing immunopathology. Supporting this hypothesis, administering sFas-L improved clinical outcome in herpes simplex virus-mediated keratitis, presumably by activating apoptosis of inflammatory cells [30]. The finding that TNFR-II is released in soluble form by T-regulatory cells and can control IL-6-mediated inflammation [31] adds further credence to the idea of immune control playing a critical role in controlling EBOV clinical severity.…”

Section: Immune Modulation and Evdmentioning

confidence: 92%

Kinetic Analysis of Biomarkers in a Cohort of US Patients With Ebola Virus Disease

McElroy¹,

Harmon²,

Flietstra³

et al. 2016

Clinical Infectious Diseases

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Biomarkers that were associated with severe EVD were proinflammatory and indicative of endothelial or coagulation cascade dysfunction, as has been seen historically in patients with fatal outcomes. In contrast, biomarkers that were associated with moderate EVD were suggestive of a strong interferon response and control of both innate and adaptive responses. Therefore, clinical interventions that modulate the phenotype and magnitude of immune activation may be beneficial in treating EVD.

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Section: Immune Modulation and Evdmentioning

confidence: 92%

Kinetic Analysis of Biomarkers in a Cohort of US Patients With Ebola Virus Disease

McElroy¹,

Harmon²,

Flietstra³

et al. 2016

Clinical Infectious Diseases

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“…Necrotizing stromal keratitis (NSK) is induced by the recurrent attacks of discoid or dendritic keratitis, which results from the infection of herpes simplex virus in corneal stromal cells [12,13]. NSK is clinically characterized by delayed hypersensitivity, including corneal neovascularization and severe inflammatory cell infiltration [14]. NSK might result in descemetocele, hypopyon, corneal perforation, and even mixed infection, with extremely poor prognosis.…”

Section: Discussionmentioning

confidence: 99%

Effects of deep lamellar keratoplasty on severe necrotizing stromal keratitis

Shi¹,

Liu²,

Jia³

et al. 2018

biomedicalresearch

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Objective: This study is to investigate the application of deep lamellar keratoplasty (DLKP) in the treatment of necrotizing stromal keratitis (NSK). Methods: Corneal confocal microscopy and histopathological examination were performed before surgery. DLKP and penetrating keratoplasty (PKP) were performed on 14 and 20 NSK subjects, respectively, followed by proper drug administration. In the follow-up period, the pathological features were evaluated and compared. Results: Significant corneal neovascularization and inflammatory cell infiltration were observed in NSK patients before surgery. After proper drug treatments, PKP and DLKP were performed. In the followup period, the visual acuity was elevated in the PKP and DLKP groups at 1 y after surgery. Moreover, corneal opacity was observed in 2 corneal grafts in the PKP group, while all the corneal grafts were transparent in the DLKP group. Furthermore, compared with the PKP group, corneal endothelial cell numbers at 6 and 12 months after surgery were significantly higher in the DLKP group. On the other hand, there were 2 eyes reporting virus recurrence in the PKP group, while no virus recurrence was reported in the DLKP group. Moreover, 4 eyes were accompanied with neovascularization at the corneal graft edge in the PKP group, while there was only 1 eye associated with neovascularization in the DLKP group. Furthermore, 5 cases in the PKP group reported graft rejection, while no rejection case was reported for DLKP. Conclusion: DLKP provides superior outcomes to PKP in treating NSK, which might be an ideal alternative option for the disease treatment.

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“…Apoptosis of salivary glands T cells was decreased in SS patients [ 34 ]. It was demonstrated that sFasL treatment has potential therapeutic benefit in reducing inflammatory infiltrate and neovascularization in primary and recurrent forms of herpetic stromal keratitis and that it does so by augmenting the restriction of Fas+ inflammatory cells mediated by membrane FasL [ 35 ]. Previous study also provided evidence that sFasL could be related to the mechanism involved in the elimination of the parasite [ 36 ].…”

Section: Discussionmentioning

confidence: 99%

A Potential of sFasL in Preventing Gland Injury in Sjogren’s Syndrome

Luo

Wang

et al. 2017

BioMed Research International

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Fas and its ligand FasL, members of tumor necrosis factor receptor superfamily, have been implicated in the process of cell apoptosis. FasL consists of two forms, membrane FasL (mFasL) and soluble FasL (sFasL). sFasL can be produced by mFasL cleaved by matrix metalloproteinases (MMP) and also reveals a role for binding to Fas which is expressed on cell surface. Although Fas/FasL axis has been implicated in a variety of diseases, its role in Sjogren's syndrome still remains ill defined. In this study, we investigated the potential of sFasL in the pathogenesis of Sjogren's syndrome (SS). We found that the serum levels of sFasL in SS patients were significantly lower than healthy subjects. Moreover, serum levels of sFasL in patients with mild disease activity were higher than patients with severe disease activity. There is a positive correlation of the serum level of sFasL with uptake index of parotid gland in our expectation. In addition, liver injury involvement in SS patients showed decreased level of sFasL. Furthermore, we here also observed that the protective cytokine IL-10 expression was positively correlated with sFasL expression. Thus, our results here suggest a potential of sFasL in maintaining gland organ homeostasis.

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Therapeutic Use of Soluble Fas Ligand Ameliorates Acute and Recurrent Herpetic Stromal Keratitis in Mice

Abstract: This study provides evidence that sFasL treatment has potential therapeutic benefit in reducing inflammatory infiltrate and neovascularization in primary and recurrent forms of HSK, and that it does so by augmenting the restriction of Fas+ inflammatory cells mediated by membrane FasL.

Cited by 13 publications

References 48 publications

Kinetic Analysis of Biomarkers in a Cohort of US Patients With Ebola Virus Disease

Kinetic Analysis of Biomarkers in a Cohort of US Patients With Ebola Virus Disease

Effects of deep lamellar keratoplasty on severe necrotizing stromal keratitis

A Potential of sFasL in Preventing Gland Injury in Sjogren’s Syndrome

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