Therapeutic uses of epicatechin in diabetes and cancer

Abdulkhaleq, Layth Abdulmajeed; Assi, Mohammed Abdulrazzaq; Noor, Mohd Hezmee Mohd; Abdullah, Rasedee; Saad, Mohd Zamri; Taufiq‐Yap, Yun Hin

doi:10.14202/vetworld.2017.869-872

Cited by 91 publications

(42 citation statements)

References 41 publications

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“…In this study, HPLC of PPE showed a significant amount of various phenolic compounds and flavonoids, thereby indicating that the extract could be useful in reducing inflammation. Catechin hydrate [30], (−) epicatechin [31] and p-coumaric acid [32] are natural phenolic compounds and flavonoids which act as potent antioxidants to scavenge free radicals in the body. Quercetin is also categorized as a flavonoid which exerts antioxidant activity, thereby useful in various anti-inflammatory diseases [33].…”

Section: Discussionmentioning

confidence: 99%

A mechanistic approach to HPLC analysis, antinociceptive, anti-inflammatory and postoperative analgesic activities of panch phoron in mice

Gias

Afsana

Debnath

et al. 2020

BMC Complement Med Ther

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Background: Panch phoron is a mixture of five spices containing an equal proportion of Foeniculum vulgare (fennel), Trigonella foenum-graecum Linn (fenugreek), Nigella sativa (black cumin), Cuminum cyminum (cumin) and Brassica nigra (black mustard). The mixture is commonly used in Bangladeshi cuisine and possesses many pharmacological effects. In this study, we evaluated the antinociceptive and anti-inflammatory activities of aqueous panch phoron extract (PPE) in vivo, its possible mechanism of action and phytochemical analysis by High-Performance Liquid Chromatography (HPLC). We also investigated the effect of PPE on postoperative pain in mice. Methods: HPLC was carried out using LC-20A Modular HPLC system to identify the bioactive compounds present in PPE. Five groups of Swiss albino male mice (n = 6 per group) were orally treated with 10 ml/kg of distilled water or 10 mg/kg of sodium diclofenac or three doses of PPE (100 mg/kg, 300 mg/kg, 500 mg/kg). In vivo assessment was carried out by the writhing test, tail-flick test, formalin test, and carrageenan induced paw edema test. The opioid antagonist, naloxone was used in the acetic acid test to evaluate the involvement of opioid receptors. To assess the effect of PPE in postoperative pain, mice that underwent sciatic nerve surgery were measured for the paw withdrawal latency in a hot water bath. Results: In HPLC analysis, different types of phenolic compounds and flavonoids, including catechin hydrate, paracoumaric acid, vanillic acid, and syringic acid were detected. Treatment with PPE exhibited dose-dependent antinociceptive and anti-inflammatory activities in pain models (p < 0.05). Furthermore, naloxone did not reverse the effect of PPE in the writhing test. Mice that underwent sciatic nerve surgery showed that the paw withdrawal latency increased gradually over 7 days. Conclusions: Our results demonstrate that PPE has significant antinociceptive and anti-inflammatory activities and can provide significant postoperative analgesia.

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Section: Discussionmentioning

confidence: 99%

A mechanistic approach to HPLC analysis, antinociceptive, anti-inflammatory and postoperative analgesic activities of panch phoron in mice

Gias

Afsana

Debnath

et al. 2020

BMC Complement Med Ther

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“…Some of these polyphenols were extracted in this study in great abundance (≥1000 µg/g dw). First of them is epicatechin (>1300 µg/g dw), it was reported that the consumption of epicatechin reduces blood glucose levels in diabetic patients and has an anticancer effect, which was attributed to its antioxidant properties, as well as antiangiogenic and direct cytotoxicity to cancer cells [44]. The second one is procyanidin B2 (>1500 µg/g dw).…”

Section: -Hba 4-hca Ca 4-mbamentioning

confidence: 99%

Peel of Traditional Apple Varieties as a Great Source of Bioactive Compounds: Extraction by Micro-Matrix Solid-Phase Dispersion

Lončarić

Matanović

Ferrer

et al. 2020

Foods

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Micro matrix solid phase dispersion (micro-MSPD) was optimized by response surface methodology for the extraction of polyphenols from the peel of twelve traditional and eight commercial apple varieties grown in Croatia. The optimized micro-MSPD procedure includes the use of 0.2 g of sample, 0.8 g of dispersant, a 57% solution of methanol in water as the solvent and 5 mL of extract volume. The total polyphenolic index (TPI) and antioxidant activity (AA) were measured by spectrophotometric assays. Eighteen polyphenolic compounds were identified in all investigated apples by HPLC-DAD and LC-(ESI)-MS. The peel of traditional apple varieties had higher contents of all investigated polyphenols. Calculated relative contribution of polyphenol groups indicated non-flavonoids (28.6%) and flavanols (46.2%) as the major contributors to the total polyphenolic content in traditional and commercial apple varieties, respectively. The most abundant polyphenol in traditional apple peel was chlorogenic acid, procyanidin B2 and epicatechin (1143 ± 755 µg/g dw, 954 ± 343 µg/g dw and 560 ± 362 µg/g dw, respectively). The peel of varieties ‘Apistar’, ‘Bobovac’ and ‘Božićnica’ could be highlighted as an important source of polyphenols.

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“…This compound acts in beta-cell damage prevention, as shown in rats. Additionally, studies performed in diabetic animal models with either epicatechin or a crude alcohol extract from P. marsupium have revealed their ability to regenerate pancreatic beta-cells with a preserved function [121]. Among the components of P. marsupium, epicatechin and catechin, which belong to flavan-3-ols family, are composed of glycosides and esters that may be responsible for their anti-diabetic action [122].…”

Section: Pterocarpus Marsupium and Other Epicatechin-containing Plantsmentioning

confidence: 99%

Sugar-Lowering Drugs for Type 2 Diabetes Mellitus and Metabolic Syndrome—Review of Classical and New Compounds: Part-I

et al. 2019

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Diabetes mellitus (DM) is a metabolic disorder characterized by chronic hyperglycemia together with disturbances in the metabolism of carbohydrates, proteins and fat, which in general results from an insulin availability and need imbalance. In a great number of patients, marketed anti-glycemic agents have shown poor effectiveness in maintaining a long-term glycemic control, thus being associated with severe adverse effects and leading to an emerging interest in natural compounds (e.g., essential oils and other secondary plant metabolites, namely, flavonoid-rich compounds) as a novel approach for prevention, management and/or treatment of either non-insulin-dependent diabetes mellitus (T2DM, type 2 DM) and/or Metabolic Syndrome (MS). In this review, some of these promising glucose-lowering agents will be comprehensively discussed.

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Therapeutic uses of epicatechin in diabetes and cancer

Cited by 91 publications

References 41 publications

A mechanistic approach to HPLC analysis, antinociceptive, anti-inflammatory and postoperative analgesic activities of panch phoron in mice

A mechanistic approach to HPLC analysis, antinociceptive, anti-inflammatory and postoperative analgesic activities of panch phoron in mice

Peel of Traditional Apple Varieties as a Great Source of Bioactive Compounds: Extraction by Micro-Matrix Solid-Phase Dispersion

Sugar-Lowering Drugs for Type 2 Diabetes Mellitus and Metabolic Syndrome—Review of Classical and New Compounds: Part-I

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