Therapeutic Uses of the Drugs of Abuse

“…Other studies with a lower quality control group (patients did not receive a treatment comparable to the treatment group) also found significant differences in favor of LSD treatment in alcoholism (60,81). Likewise, according to a retrospective analysis of studies published in the late 1960s, LSD is a potential therapeutic agent for the treatment of chronic alcoholism (82). A recent metaanalysis ( 83) of six of the clinical trials chosen for this review showed the superiority of LSD over placebo in the treatment of alcoholism with an odds ratio (OR) of 1.96 (95% confidence interval 1.36-2.84 OR, p = 0.0003).…”

Section: Discussionmentioning

confidence: 99%

Therapeutic Use of LSD in Psychiatry: A Systematic Review of Randomized-Controlled Clinical Trials

Fuentes

Fonseca

Elices³

et al. 2020

Front. Psychiatry

116

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“…However, it was Osmond who coined the term ‘psychedelics’ and revolutionized their use in chronic alcoholics in 1957 [Osmond, 1957]. LSD has the potential to treat alcoholism according to a retrospective analysis of studies published in the late 1960s [Ungerleider and Andrysiak, 2006].…”

Section: Is Lsd Only ‘Bad’? a Brief Passage Through Timementioning

confidence: 99%

“…In addition to the marked hallucinogenic effects, LSD exerts methylenedioxymethamphetamine-like empathogenic mood effects that may be useful in psychotherapy. In a recent study, LSD showed promising results in translational psychiatric research in a controlled clinical setting as it altered sensorimotor gating in a human model of psychosis [Schmid et al 2015; Ungerleider and Andrysiak, 2006].…”

Section: Looking At the Uses In The Present Lightmentioning

confidence: 99%

Lysergic acid diethylamide: a drug of ‘use’?

Das

Barnwal

Ramasamy

et al. 2016

Therapeutic Advances in Psychopharmacology

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Lysergic acid diethylamide (LSD), described as a classical hallucinogen, began its journey from the middle of the last century following an accidental discovery. Since then, it was used as a popular and notorious substance of abuse in various parts of the world. Its beneficial role as an adjunct to psychotherapy was much unknown, until some 'benevolent' experiments were carried out over time to explore some of its potential uses. But, many of its effects were unclear and seemed to be a psychedelic enigma. In this review article, we have described the receptor pharmacology, mechanism of action, effects and adverse effects of LSD on the normal body system. We have also highlighted its addictive potentials and the chances of developing tolerance. We have assimilated some of the interesting therapeutic uses of this drug, such as an antianxiety agent, a creativity enhancer, a suggestibility enhancer, and a performance enhancer. We have also described LSD to be successfully used in drug and alcohol dependence, and as a part of psychedelic peak therapy in terminally ill patients. The relevant chronological history and literature in the light of present knowledge and scenarios have been discussed. Based on available evidence, LSD could be tried therapeutically in certain specific conditions under controlled settings. But as we mention, due to all the safety concerns, the use of this nonaddictive 'entheogen' in actual practice warrants a lot of expertise, caution, cooperation and ethical considerations.

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Therapeutic Uses of the Drugs of Abuse

Cited by 6 publications

References 13 publications

After more than sixty years we are still unclear whether LSD has a place in clinical psychiatry

After more than sixty years we are still unclear whether LSD has a place in clinical psychiatry

Therapeutic Use of LSD in Psychiatry: A Systematic Review of Randomized-Controlled Clinical Trials

Lysergic acid diethylamide: a drug of ‘use’?

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