Therapeutic value of oral supplementation with melon superoxide dismutase and wheat gliadin combination

Romão, Susana

doi:10.1016/j.nut.2014.10.006

Cited by 38 publications

(40 citation statements)

References 42 publications

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“…14 A combination of Cucumis melo extract and wheat gliadin increases endogenous antioxidant levels and also promoted the cellular defences by strengthening the antioxidant status, may also be useful in the treatment of endometriosis. 15 We are interested in researching three potential antioxidant sources: Kebar grass, green tea and the combination of melon superoxide dismutase and wheat gliadin (Glisodin). Kebar grass is one of Indonesia's medicinal plants originally from Papua and traditionally used as fertilising support since a long time ago.…”

Section: Introductionmentioning

confidence: 99%

“…We thought they could be used as alternative therapies for endometriosis. 19 This research examined endometriosis mice models fed with Kebar grass extract (KGE), green tea extract (GTE) or Cucumis melo extract and wheat gliadin combination (CME-gliadin) for 14 days, compared with the control group without any treatment. We used mice in this experiment because the existing research on KGE as an alternative therapy for endometriosis is still limited.…”

Section: Introductionmentioning

confidence: 99%

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Antioxidant Herbs Supplementation Inhibits Endometriosis Extension in Mice

Trisetiyono

Widjiati

Hidayat

et al. 2019

J. Biomed. Transl. Res.

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Background: Increased oxidative stress causes inflammation and increases angiogenesis. It presumed to promote the proliferation of endometriosis tissue. Kebar grass (Biophytum petersianum) and other herbs such as green tea and Cucumis melo, which contain high antioxidants, are expected to decrease oxidative stress, inflammation, angiogenesis, and reduced endometriosis implants.Objective: To investigate the effects of Kebar grass, green tea, and Cucumis melo to malondialdehyde serum, tumor necrosis factor alpha, and vascular endothelial growth factor expression, and the area of the endometriotic implants.Methods: Twenty-eight mice were divided into four groups, i.e., the first group of endometriosis mice was given Kebar grass extract; the second group was assigned green tea extract, the third group was given the combination of Cucumis melo extract–gliadin, and the last containing the untreated endometriosis mice as the control. Each treatment was given for 14 days. The data of MDA serum level, the area of the endometriotic implants, TNF-α, and VEGF expression were collected and analyzed.Results: The MDA serum levels of the groups treated with Kebar grass extract, green tea extract, and Cucumis melo extract – gliadin were significantly lower (p=0.001) than the control group. TNF-α expression of the groups provided with each treatment also lower than the control groups (p=0.002). However, only the administration of the Cucumis melo extract–gliadin resulted in lower VEGF expression compare with the control (p=0.017). Finally, the area of the endometriotic implants of the mice models administered with each treatment was smaller than the control group (p=0.003).Conclusion: Kebar grass as well as green tea and Cucumis melo–gliadin inhibits endometriotic implants extension by decreasing MDA serum and TNF-α expression.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Antioxidant Herbs Supplementation Inhibits Endometriosis Extension in Mice

Trisetiyono

Widjiati

Hidayat

et al. 2019

J. Biomed. Transl. Res.

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“…Oral formulations, in the form of coated gastroresistant tablets and capsules, allow SAM irritating activity on the gastric mucosa to be overcome, also hiding its unpleasant taste. SOD is widely used as nutritional supplements to contrast oxidative stress and ROS, with no side effects reported [ 48 ]. Nutritional lifestyle regulates the intake and bioavailability of metabolites and cofactors.…”

Section: Discussionmentioning

confidence: 99%

S-Adenosylmethionine and Superoxide Dismutase 1 Synergistically Counteract Alzheimer’s Disease Features Progression in TgCRND8 Mice

et al. 2017

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Recent evidence emphasizes the role of dysregulated one-carbon metabolism in Alzheimer’s Disease (AD). Exploiting a nutritional B-vitamin deficiency paradigm, we have previously shown that PSEN1 and BACE1 activity is modulated by one-carbon metabolism, leading to increased amyloid production. We have also demonstrated that S-adenosylmethionine (SAM) supplementation contrasted the AD-like features, induced by B-vitamin deficiency. In the present study, we expanded these observations by investigating the effects of SAM and SOD (Superoxide dismutase) association. TgCRND8 AD mice were fed either with a control or B-vitamin deficient diet, with or without oral supplementation of SAM + SOD. We measured oxidative stress by lipid peroxidation assay, PSEN1 and BACE1 expression by Real-Time Polymerase Chain Reaction (PCR), amyloid deposition by ELISA assays and immunohistochemistry. We found that SAM + SOD supplementation prevents the exacerbation of AD-like features induced by B vitamin deficiency, showing synergistic effects compared to either SAM or SOD alone. SAM + SOD supplementation also contrasts the amyloid deposition typically observed in TgCRND8 mice. Although the mechanisms underlying the beneficial effect of exogenous SOD remain to be elucidated, our findings identify that the combination of SAM + SOD could be carefully considered as co-adjuvant of current AD therapies.

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“…When mice received this it was found to promote antioxidant defenses in the brain and to prevent stress induced impairment of memory and in other animal studies, it was concluded that supplementation with gliadin-combined standardized melon SOD extract (Glisodin) promoted the cellular antioxidant status and protected against oxidative stress-induced cell death [45,46]. No concrete conclusions have been made about the health benefits of human SOD-2 supplementation and studies thus far all state that much larger studies are needed [47].…”

Section: Sod-2 Transcription Factorsmentioning

confidence: 99%

A Review of the Role of Mitochondrial Manganese Superoxide Dismutase in Human Disorders, such as, Diabetes

Houldsworth¹

2016

JED

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Therapeutic value of oral supplementation with melon superoxide dismutase and wheat gliadin combination

Cited by 38 publications

References 42 publications

Antioxidant Herbs Supplementation Inhibits Endometriosis Extension in Mice

Antioxidant Herbs Supplementation Inhibits Endometriosis Extension in Mice

S-Adenosylmethionine and Superoxide Dismutase 1 Synergistically Counteract Alzheimer’s Disease Features Progression in TgCRND8 Mice

A Review of the Role of Mitochondrial Manganese Superoxide Dismutase in Human Disorders, such as, Diabetes

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