Thérapeutique du glaucome primitif à angle ouvert à Cotonou : à propos de 224 cas

Sounouvou, I.; Tchabi, S; Monteiro, Sara; Yehouessi, L; Doutétien, C; Bassabi, S

doi:10.1016/j.jfo.2011.02.015

Cited by 5 publications

(5 citation statements)

References 9 publications

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“…In fact, beta-blockers are the molecules prescribed as first-line treatment because of their efficacy, local tolerance and affordable cost. These results are similar to those of Eballe et al [12] and Sounouvou et al [14] in Benin, who observed a predominance of beta-blockers use at 77% and 54%, respectively. However, Domngang et al, in 2023, found monotherapy, in 60% of cases, with prostaglandin agonists as the most prescribed treatment from a hospital based study carried out in an urban area in Cameroon [9].…”

Section: Discussionsupporting

confidence: 91%

Epidemiological, Clinical, Therapeutic and Evolutive Profile of Primary Open-Angle Glaucoma in a Cameroonian Population

Domngang,

Makamwe Tagne,

Tedong

et al. 2024

OJOph

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Background: Sub-Saharan Africa has the highest prevalence of primary open-angle glaucoma (POAG), at 4.2%. The efficacy of medical treatment has been demonstrated and remains one of the treatments of choice for POAG. However, in sub-Saharan Africa, its effectiveness has many challenges, due to multiple factors, including cost and access to care. Thus, the present study aimed to determine the epidemiological, clinical, therapeutic and evolutive profile of primary open-angle glaucoma patients. Methodology: A descriptive cross-sectional study was carried out in two hospitals in western Cameroon. Epidemiological, clinical, therapeutic, and evolutionary data on intraocular pressure at one year after medical treatment were analyzed. SPSS version 23 software was used for statistical analysis, with a significant p-value set at 5%. Results: A total of 201 patients with POAG were included in the study. The population comprised 100 men and 101 women, with a mean age of 54 ± 12 years. At diagnosis, the mean intraocular pressure was 23.9 ± 8.70 mmHg for the right eye and 25.5 ± 9.57 mmHg for the left eye. The mean cup/disc ratio was 0.64 ± 0.2 [0.2 -1] and 0.67 ± 0.19 [02 -1] in the right and left eyes, respectively. Monotherapy was the most prescribed treatment [59.2%]. After one year of treatment, intraocular pressure was reduced by 15.5% with beta-blockers, 23.66% with prostaglandins, 19.11% with carbonic anhydrase inhibitors, 35, 92% with beta-blockers and carbonic anhydrase inhibitors, 25.92% with beta-blockers and prostaglandins, 48.03% with carbonic anhydrase inhibitors and prostaglandin agonists, and 38.77% with triple therapy. Taking glaucoma severity into account, a significant reduction in intraocular pressure at one year was observed in all participants [p < 0.05]. However, the target pressure was obtained in 47%, 20% and 14% of eyes suffering of mild, moderate, and severe grade of POAG respectively. Conclusion: In the present

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Section: Discussionsupporting

confidence: 91%

Epidemiological, Clinical, Therapeutic and Evolutive Profile of Primary Open-Angle Glaucoma in a Cameroonian Population

Domngang,

Makamwe Tagne,

Tedong

et al. 2024

OJOph

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“…As for treatment, most patients (64.91%) benefited from monotherapy. The same observation was made by Sounouvou [10] and Ouattara [13] who found respectively 59.4% and 54.16% of people benefiting from monotherapy. Monotherapies with a beta blocker were the most frequently used (50.88%), probably due to their relatively low costs since the advent of generics [15] [16].…”

Section: Discussionsupporting

confidence: 82%

“…The male gender was in the majority with a ratio of 1.5. The male predominance was found in most African studies, notably those of Ahnoux in Ivory Coast [9] and Sounouvou in Benin [10] with respective proportions of 59.4% and 57.6% men. However, other authors such as Demailly [11] in France and Mac Donald [12] in Canada noted an equal distribution between the sexes in a respective study.…”

Section: Discussionmentioning

confidence: 77%

“…However, other authors such as Demailly [11] in France and Mac Donald [12] in Canada noted an equal distribution between the sexes in a respective study. This difference could be explained by men's greater accessibility to medical care in the African context due to greater autonomy, particularly on the financial level [10], whereas in developed countries, insurance systems and health coverage has reduced this inequality. This male predominance would then be a selection bias because gender would not be a risk factor for the disease, given the discordant data from numerous studies on the subject.…”

Section: Discussionmentioning

confidence: 99%

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Cost of Medical Treatment for Primary Open-Angle Glaucoma in Relation to Patients’ Income and Its Impact on the Prognosis of the Disease, in Bouaké University Hospital

Ouattara,

Ella Godé,

Diabaté

et al. 2024

OJOph

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Introduction: Medical treatment for POAG is continuous and lifelong treatment. The aim of this study was to evaluate the relationship between the cost of this treatment and patients' income and the impact of this relationship on treatment compliance. Materials and Methods: Prospective cross-sectional study with a descriptive aim covering sociodemographic data, average incomes, and direct and indirect costs of treatment of 57 patients followed for POAG during the period from January 1, 2012, to December 31, 2016 (5 years). Results: The patients were aged 25 to 77 years (mean = 54.4 years) with a male predominance (sex ratio = 1.5). Retirees were the most represented (26.32%), followed by workers in the informal sector (14.04%) and housewives (12.28%). Patients who had an annual income less than or equal to 900,000 CFA francs (€1370.83) per year represented 56.14% and those who did not have health coverage represented 57.89%. The treatment was monotherapy (64.91%), dual therapy (31.58%) or triple therapy (3.05%) and the average ratio of "annual cost of treatment to annual income" was 0.56 with for maximum 2.23 and 0.02 as minimum. Patients who considered the cost of treatment unbearable for their income represented 78.95%. Conclusion: Prevention of blindness due to glaucoma requires early detection but also the establishment of health coverage mechanisms to improve compliance with medical treatment. In addition, consideration should be given to the development of glaucoma surgery in our country, the indication of which could be the first intention in certain patients, considering for those patients, the geographical and financial accessibility of medical treatment.

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“…The IOP-lowering effects of antiglaucoma medications on POAG patients ranged from 12.8% with the use of beta-blockers 17 to 63.7% with the use of Timolol–Latanoprost combination 40 ( Table 2 ). This evidence is, however, weak because all the three studies 17 , 36 , 40 that reported the IOP-lowering effects of medical treatment of glaucoma were retrospective patient record studies which are prone to selection and misclassification bias.…”

Section: Discussionmentioning

confidence: 99%

What Glaucoma Surgical Rate could Serve as a Target for West Africa? A Systematic Review

Eni¹,

Nolan²,

Eval³

2021

Journal of Current Glaucoma Practice

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A bstract Aim and objective This study aimed to use the available evidence to model a glaucoma surgical rate (GSR), which could serve as a target for West Africa. Materials and methods A comprehensive literature search was performed in Medline, Embase, Global Health, and CINAHL, and studies published between January 1, 2000, and June 19, 2020, were retrieved. Study selection, quality appraisal, and data extraction were performed and the results of individual studies aggregated and presented using a narrative synthesis. Using these data, we aimed to construct a target GSR per million population per year that is sufficient to offer trabeculectomy to most patients with glaucoma who are diagnosed, and for whom other treatment options are either ineffective or inappropriate. The findings were then used to develop a trabeculectomy target for West Africa. Results Initial searches returned 633 references, of which 33 unique studies were eligible for inclusion. The glaucoma prevalence population-based surveys identified, reported a wide range of prevalence of primary open-angle glaucoma (POAG) ranging from 1.0 to 8.4%. The studies on glaucoma medications reported intraocular pressure (IOP)-lowering effects ranging from 12.8% (beta-blockers) to 63.7% (Timolol–Latanoprost combinations). The adherence rate to antiglaucoma medications spanned from 10.3 to 82.3%. Regarding selective laser trabeculoplasty (SLT), only two studies were found. All the studies on trabeculectomy showed a significant reduction in IOPs at different follow-up periods with many reporting the absence of vision-threatening complications. From these available data, a GSR of 50 trabeculectomies was suggested for countries in West Africa. Conclusion This trabeculectomy target metric is expected to minimize POAG blindness in the West African subregion. Clinical significance The proposed GSR will enable eye care workers involved in glaucoma care in West Africa to assess their efforts compared with the proposed target. The gap will signal the potential for improvement. How to cite this article Eni EN, Nolan W, Eval B, et al. What Glaucoma Surgical Rate could Serve as a Target for West Africa? A Systematic Review. J Curr Glaucoma Pract 2021;15(1):19–27.

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Thérapeutique du glaucome primitif à angle ouvert à Cotonou : à propos de 224 cas

Cited by 5 publications

References 9 publications

Epidemiological, Clinical, Therapeutic and Evolutive Profile of Primary Open-Angle Glaucoma in a Cameroonian Population

Epidemiological, Clinical, Therapeutic and Evolutive Profile of Primary Open-Angle Glaucoma in a Cameroonian Population

Cost of Medical Treatment for Primary Open-Angle Glaucoma in Relation to Patients’ Income and Its Impact on the Prognosis of the Disease, in Bouaké University Hospital

What Glaucoma Surgical Rate could Serve as a Target for West Africa? A Systematic Review

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Thérapeutique du glaucome primitif à angle ouvert à Cotonou : à propos de 224 cas

Cited by 5 publications

References 9 publications

Epidemiological, Clinical, Therapeutic and Evolutive Profile of Primary Open-Angle Glaucoma in a Cameroonian Population

Epidemiological, Clinical, Therapeutic and Evolutive Profile of Primary Open-Angle Glaucoma in a Cameroonian Population

Cost of Medical Treatment for Primary Open-Angle Glaucoma in Relation to Patients’ Income and Its Impact on the Prognosis of the Disease, in Bouak&#233; University Hospital

What Glaucoma Surgical Rate could Serve as a Target for West Africa? A Systematic Review

Contact Info

Product

Resources

About

Cost of Medical Treatment for Primary Open-Angle Glaucoma in Relation to Patients’ Income and Its Impact on the Prognosis of the Disease, in Bouaké University Hospital