Thérapeutique du rétinoblastome : expérience sénégalaise

Sow, Adjaratou Dieynabou; Roth, P.A. Ndoye; Moreira, Carlos Heitor Cunha; Akondé, F.B.; Ka, A.M.; Sow, M.; Ba, E.A.; Khouma, A.M. Wane; Ndiaye, Matar

doi:10.1016/j.jfo.2013.12.009

Cited by 14 publications

(17 citation statements)

References 14 publications

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“…We prospectively studied 12 consecutive children (16 eyes) diagnosed with extra-ocular retinoblastoma presenting 46% of all retinoblastoma diagnosed in our center. A comparatively larger percentage of orbital extensions (52%) have been reported in a Malaysian study [ 14 ], 37.1% in India [ 13 ], 52.3% in Senegal [ 15 ]. Orbital retinoblastoma was reported in very low frequency from some of the developed countries like USA (5%) [ 16 ].…”

Section: Discussionmentioning

confidence: 99%

“…Retinoblastoma has no sex predilection; there was not much difference in the occurrence of retinoblastoma in boys (60%) and girls (40%). The average age at diagnosis is 18 months and vast majority become clinically apparent before the age of 3 years, The age at diagnosis of retinoblastoma in developing countries varies from 24 months to 3 years [ 13 , 15 ]. In this study, the age of our patients ranged from 8 months to 4 years and averaged 27 months which is slightly higher.…”

Section: Discussionmentioning

confidence: 99%

“…In this study, the age of our patients ranged from 8 months to 4 years and averaged 27 months which is slightly higher. Patients with bilateral tumors present earlier than those with unilateral involvement [ 15 ]. In our series, Bilateral retinoblastoma was seen in 41,6% of patients which is similar to the figures reported from USA (41.5% ) [ 16 ], India (37.2% ) [ 13 ].…”

Section: Discussionmentioning

confidence: 99%

“…The mean lag period in our patients was 10 months, with no statistically significant difference as per laterality and age. Other studies from the developing world have also described a long lag period and have analyzed various reasons for the same [ 13 , 15 ]. Erwenne and Franco [ 12 ] concluded that delayed presentation with extra-ocular invasion is strongly associated with age at diagnosis and lateness of referral.…”

Section: Discussionmentioning

confidence: 99%

“…The frequency of common modes of presentation of retinoblastoma in our study is consistent with many studies from different parts of the world. Leucocoria as presenting sign was seen in 22.6% [ 13 ] to 97.9%[ 16 ] of patients of retinoblastoma, while strabismus was noted in 5.6% [ 13 ] to 26% [ 15 ] of these patients at the time of diagnosis. In addition to the above, Abramson [ 16 ] reported many uncommon/rare presenting signs like anisocoria, heterochromia iridis, inflammatory signs, nystagmus, microphthalmia/buphthalmos, proptosis, orbital cellulitis, hyphema, ptosis, aniridia, phthisis, vitreous haemorrhage in their study of 1265 patients of retinoblastoma.…”

Section: Discussionmentioning

confidence: 99%

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Extra-ocular retinoblastoma: about 12 cases followed at the Mohamed VI university hospital of Marrakech

Soltani¹,

Hajji²,

Hafsa³

et al. 2016

Pan Afr Med J

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Retinoblastoma is the most frequent childhood intraocular tumor. The aim of our study is to evaluate the clinical features and management of extra-ocular retinoblastoma in the Mohamed VI university hospital of Marrakech. Retrospective case series, the patient's records were reviewed for patient and tumor features, ocular management, histopathological findings, and patient survival. Over a period of three years, 35 eyes were diagnosed with retinoblastoma; 12 children (16 eyes) (46%) had extra-ocular retinoblastoma. Mean age was 27 months, 60% were males. Six cases had unilateral tumor, five bilateral and one case of trilateral retinoblastoma. There was no positive family history, proptosis was the mean mode of presentation (41,6%) followed by staphyloma (25%) orbital cellulitis (25%) and hyphema(8,3%). The median lag period was 18 months. On imaging and histopathological analysis, there was extrascleral involvement in 41.6%, involvement of orbital part of optic nerve (75%), of orbital muscles (50%) and eyelids in 16.6%. the surgical treatment included according to the degree of extension enucleation (75%) or exenteration (25%) associated to chemotherapy in all cases and one case of external beam radiation. There were 2 cases of orbital recurrence, one death and no metastases at 30 months follow-up.Orbital retinoblastoma still stands as a tall challenge requiring multi-modal and multi-disciplinary approach. Although the survival has increased over the last few years, lack of access to medical facilities, lack of education about the need for early medical attention and cultural resistance to enucleation continue to contribute to an epidemic of extra ocular disease at diagnosis in the developing world.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Extra-ocular retinoblastoma: about 12 cases followed at the Mohamed VI university hospital of Marrakech

Soltani¹,

Hajji²,

Hafsa³

et al. 2016

Pan Afr Med J

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Crocin inhibits proliferation and induces apoptosis through suppressing MYCN expression in retinoblastoma

Deng

Lü

et al. 2019

J Biochem & Molecular Tox

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The pathogenetic mechanisms of retinoblastoma are still not yet fully elucidated, putting limits to efficacious treatment. Crocin is the main component of saffron, which exhibits significant antitumorigenic properties. The aim of this paper is to investigate the effect of crocin on retinoblastoma. The effects of crocin on the proliferation of human retinoblastoma cells were determined by the 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide assay, cell number assay, and colony formation assay. Cell apoptosis induced by crocin was measured by flow cytometry analysis. Cleaved poly(ADP-ribose) polymerase and cleaved caspase-3 were tested by western blot analysis. The expression levels of MYCN were assessed by western blot and quantitative polymerase chain reaction and the stability of MYCN messenger RNA was determined by in vitro RNA degradation assays. We found that crocin significantly inhibited the cell proliferation and clonogenicity and induced cell apoptosis in Y79 and WERI-RB-1 cells. In addition, crocin treatment significantly reduced the expression and the stability of MYCN. Besides, overexpression of MYCN rescued the inhibitory effect of crocin in Y79 cells. Our findings suggest that crocin exhibits antitumorigenic effects in human retinoblastoma cell lines through a MYCN-dependent manner, which may provide guidance to logical therapeutic designs in prevention and treatment of retinoblastoma. K E Y W O R D S cleaved caspase-3, cleaved poly (ADP-ribose) polymerase, crocin, MYCN, retinoblastoma

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Retinoblastoma

Harif¹,

Stefan²

2017

Pediatric Cancer in Africa

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Thérapeutique du rétinoblastome : expérience sénégalaise

Cited by 14 publications

References 14 publications

Extra-ocular retinoblastoma: about 12 cases followed at the Mohamed VI university hospital of Marrakech

Extra-ocular retinoblastoma: about 12 cases followed at the Mohamed VI university hospital of Marrakech

Crocin inhibits proliferation and induces apoptosis through suppressing MYCN expression in retinoblastoma

Retinoblastoma

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