Thérapie cellulaire par cellules souches mésenchymateuses, un nouvel espoir pour les pathologies oculaires

Denoyer, Alexandre; Brignole‐Baudouin, Françoise

doi:10.1016/j.jfo.2015.05.003

Cited by 4 publications

(1 citation statement)

References 62 publications

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“…MSCs are known for their ability to differentiate into multiple cell types, high migratory and immunomodulatory capacities, and low immunogenicity activity. Recent studies have shown that MSCs could potentially restore certain eye diseases, making them an advanced technology with therapeutic applications [4]. This review study examined different types of stem cells based on their origin and differentiation abilities.…”

Section: Introductionmentioning

confidence: 99%

Exploring the Regenerative Potential of Stem Cells for Treating Eye Diseases: A Review of the New Findings

Akbaribazm

2024

OBM Genet

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The escalating prevalence of vision loss due to eye diseases has instigated a quest for innovative therapies, given that conventional approaches often fall short in repairing and regenerating damaged eye tissues, particularly the retina. Stem cell-based interventions have emerged as a promising avenue, with numerous studies in animal models and human trials exploring their potential to enhance visual acuity. Beyond addressing conditions like age-related macular degeneration (AMD) and diabetic retinopathy (DR), stem cell therapies demonstrate efficacy in treating genetic disorders such as retinitis pigmentosa (RP). In severe eye damage necessitating regeneration, stem cells play a pivotal role, leveraging their regenerative capabilities. Noteworthy is the transplantation of retinal pigment epithelial (RPE) cells derived from embryonic stem cells (ESCs) and induced pluripotent stem cells (iPSCs), showcasing promising results in preclinical models and clinical studies, leading to improved retinal function without severe side effects. Mesenchymal stem cells (MSCs) have successfully treated optic neuropathy, RP, DR, and glaucoma, yielding positive clinical outcomes. The safety of adult stem cells, particularly MSCs derived from adipose tissue or bone marrow, has been firmly established. This review highlights significant advancements in utilizing human ESC-derived retinal pigmented epithelium and iPSCs for treating eye injuries. While cell-based therapy is relatively nascent, with numerous clinical trials pending review, stem cells' regenerative potential and clinical applications in addressing eye diseases offer substantial promise. This study aims to comprehensively examine the applications of stem cells in the context of eye diseases and their potential role in regenerative medicine.

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Section: Introductionmentioning

confidence: 99%

Exploring the Regenerative Potential of Stem Cells for Treating Eye Diseases: A Review of the New Findings

Akbaribazm

2024

OBM Genet

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The Potentials and Caveats of Mesenchymal Stromal Cell-Based Therapies in the Preterm Infant

Gronbach

Shahzad

Radajewski

et al. 2018

Stem Cells International

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Preponderance of proinflammatory signals is a characteristic feature of all acute and resulting long-term morbidities of the preterm infant. The proinflammatory actions are best characterized for bronchopulmonary dysplasia (BPD) which is the chronic lung disease of the preterm infant with lifelong restrictions of pulmonary function and severe consequences for psychomotor development and quality of life. Besides BPD, the immature brain, eye, and gut are also exposed to inflammatory injuries provoked by infection, mechanical ventilation, and oxygen toxicity. Despite the tremendous progress in the understanding of disease pathologies, therapeutic interventions with proven efficiency remain restricted to a few drug therapies with restricted therapeutic benefit, partially considerable side effects, and missing option of applicability to the inflamed brain. The therapeutic potential of mesenchymal stromal cells (MSCs)—also known as mesenchymal stem cells—has attracted much attention during the recent years due to their anti-inflammatory activities and their secretion of growth and development-promoting factors. Based on a molecular understanding, this review summarizes the positive actions of exogenous umbilical cord-derived MSCs on the immature lung and brain and the therapeutic potential of reprogramming resident MSCs. The pathomechanistic understanding of MSC actions from the animal model is complemented by the promising results from the first phase I clinical trials testing allogenic MSC transplantation from umbilical cord blood. Despite all the enthusiasm towards this new therapeutic option, the caveats and outstanding issues have to be critically evaluated before a broad introduction of MSC-based therapies.

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Potential of Mesenchymal Stem Cell-Derived Conditioned Medium/Secretome as a Therapeutic Option for Ocular Diseases

Bouche Djatche,

Zhu,

et al. 2023

Regen. Med.

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Research has shown that the therapeutic effect of mesenchymal stem cells (MSCs) is partially due to its secreted factors as opposed to the implantation of the cells into the treated tissue or tissue replacement. MSC secretome, especially in the form of conditioned medium (MSC-CM) is now being explored as an alternative to MSCs transplantation. Despite the observed benefits of MSC-CM, only a few clinical trials have evaluated it and other secretome components in the treatment of eye diseases. This review provides insight into the potential therapeutic use of MSC-CM in eye conditions, such as corneal diseases, dry eye, glaucoma, retinal diseases and uveitis. We discuss the current evidence, some limitations, and the progress that remains to be achieved before clinical translation becomes possible.

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Thérapie cellulaire par cellules souches mésenchymateuses, un nouvel espoir pour les pathologies oculaires

Cited by 4 publications

References 62 publications

Exploring the Regenerative Potential of Stem Cells for Treating Eye Diseases: A Review of the New Findings

Exploring the Regenerative Potential of Stem Cells for Treating Eye Diseases: A Review of the New Findings

The Potentials and Caveats of Mesenchymal Stromal Cell-Based Therapies in the Preterm Infant

Potential of Mesenchymal Stem Cell-Derived Conditioned Medium/Secretome as a Therapeutic Option for Ocular Diseases

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