Therapie der respiratorischen Insuffizienz

Benzer, H

doi:10.1007/978-3-642-78933-5_10

Cited by 1 publication

(1 citation statement)

References 21 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…From the very onset, barotrauma (or volutrauma) and unnecessarily high fractions of inspired oxygen should be avoided [17,45,48,76,119]. Numerous variations in ventilation techniques offer alternatives to conventional volume-controlled PEEP ventilation [4,16,17,82,90,135]. These partially maintain the patient's spontaneous respiratory drive and his respiratory muscle function while supporting ventilation with flexible technology (e.g.…”

Section: Respirator Therapymentioning

confidence: 99%

Prevention and therapy of the adult respiratory distress syndrome

Temmesfeld-Wollbrück

Walmrath

Grimminger

et al. 1995

Lung

View full text Add to dashboard Cite

The complex pathophysiology of adult respiratory distress syndrome (ARDS) makes preventive and therapeutic concepts difficult. Ample experimental evidence indicates that ARDS can be prevented by blocking systemic inflammatory agents. Clinically, only heparin, for inhibition of coagulation phenomena, is presently used among this array of approaches. Corticosteroids have not proven to be beneficial in ARDS. Alternative antiinflammatory agents are being proposed and are under current clinical investigation (e.g. indomethacin, acetylcysteine, alpha 1-proteinase inhibitor, antitumor necrosis factor, interleukin 1 receptor antagonist, platelet-activating factor antagonists). Symptomatic therapeutic strategies in early ARDS include selective pulmonary vasodilation (preferably by inhaled vasorelaxant agents) and optimal fluid balance. Transbronchial surfactant application, presently tested in pilot studies, may be available for ARDS patients in the near future and may have acute beneficial effects on gas exchange, pulmonary mechanics, and lung hemodynamics; its impact on survival cannot be predicted at the present time. Strong efforts should be taken to reduce secondary nosocomial pneumonia in ARDS patients and thus avoid the vicious circle of pneumonia, sepsis from lung infection, and perpetuation of multiple organ dysfunction syndrome. Optimal respirator therapy should be directed to ameliorate gas-exchange conditions acutely but at the same time should aim at minimizing potentially aggravating side effects of artificial ventilation (barotrauma, O2 toxicity). Several new techniques of mechanical ventilation and the concept of permissive hypercapnia address these aspects. Approaches with extracorporeal CO2 removal and oxygenation are being used in specialized centers.

show abstract