Therapie des chronischen Koronararterienverschlusses

Abstract

The present article discusses the current status of treatment strategies for chronic total occlusion (CTO) and the prospects offered by new therapies. The indication for revascularisation recognized in the current European guidelines includes the presence of typical symptoms and evidence of ischemia of over 10% of the total myocardium, while in patients with multiple vascular diseases the aim is complete revascularisation. Although the vast majority of patients with CTO fulfil these criteria, they are currently not receiving interventional treatment as frequently as expected. The reasons often given for this include the low success rates and high recurrence rates. However, both problems have been improved by drug-eluting stents (DES) on the one hand and by wire techniques and strategies on the other, such that results almost comparable with non-occluded coronary lesions can be achieved. While more advanced approaches like retrograde recanalization should be restricted to specialized centres, marked improvements can be achieved even without these special techniques by means of consistent further training and the application of modern techniques. Despite the aggressiveness of these approaches to pass through an occluded artery, the complication rate is not higher than with non-occluded lesions when the specific complications of recanalization are avoided in a careful approach. Further technical improvements are expected with the use of modern imaging techniques such as intravascular ultrasound and high-resolution CT imaging of coronary arteries.

A comparison of procedural success rate and long-term clinical outcomes between in-stent restenosis chronic total occlusion and de novo chronic total occlusion using multicenter registry data

“…Therefore, precise analysis of tissue characteristics such as calcium distribution and anatomical morphology of CTO segments such as lumen size, vessel size, lesion length, plaque burden, and optimal lesion preparation is extremely important for successful wiring and optimal stenting, which might be relevant to long-term stent patency. Modern imaging techniques, including coronary computed tomography angiogram, intravascular ultrasound, and optical coherence tomography, enable us to conduct examinations prior to and during PCI for ISR CTO [27,28]. Due to the guidance using these advanced imaging technologies, results of wire passage and optimal stent implantation are improving [29][30][31].…”

Chronic total coronary occlusion recanalization: Current techniques and new devices

“…The main reasons for this mismatch are significant technical challenges, a huge shortage of sophisticated and specialized interventionalists, the considerable time resources needed for the revascularization procedures, and a comparatively low level of reimbursement [4].…”