Therapie einer refraktären okulären Hypotonie bei Uveitis mit topischem Ibopamin

To report the incidence and management of elevated intraocular pressure (IOP) in patients with uveitis treated with the fluocinolone acetonide (FA) intravitreal implant. Design: Pooled data from 3 multicenter, doublemasked, randomized, controlled, phase 2b/3 clinical trials evaluating the safety and efficacy of the 0.59-mg or 2.1-mg FA intravitreal implant or standard therapy were analyzed. Results: During the 3-year follow-up, 71.0% of implanted eyes had an IOP increase of 10 mm Hg or more than baseline and 55.1%, 24.7%, and 6.2% of eyes reached an IOP of 30 mm Hg or more, 40 mm Hg or more, and 50 mm Hg or more, respectively. Topical IOP-lowering medication was administered in 74.8% of implanted eyes, and IOP-lowering surgeries, most of which were trabeculectomies (76.2%), were performed on 36.6% of implanted eyes. Intraocular pressure-loweringsurgerieswereconsideredasuccess(postoperative IOP of 6-21 mm Hg with or without additional IOP-lowering medication) in 85.1% of eyes at 1 year. The rate of hypotony (IOPՅ5 mm Hg) following IOP-lowering surgery (42.5%) was not different from that of implanted eyes not subjected to surgery (35.4%) (P=.09). Conclusion: Elevated IOP is a significant complication with the FA intravitreal implant but may be controlled with medication and surgery.

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Intraocular Pressure in Patients With Uveitis Treated With Fluocinolone Acetonide Implants

Goldstein

et al. 2007

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Current awareness: Pharmacoepidemiology and drug safety

2006

Pharmacoepidemiology and Drug

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Pars Plana Vitrectomy, Fluocinolone Acetonide Implantation, and Silicone Oil Infusion for the Treatment of Chronic, Refractory Uveitic Hypotony

Dayani

Chow

Stinnett

et al. 2011

American Journal of Ophthalmology

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Therapie einer refraktären okulären Hypotonie bei Uveitis mit topischem Ibopamin

Abstract: Ibopamine 2 % eye drops in combination with topical steroids are a therapeutic option in uveitis-associated ocular hypotony.

Cited by 5 publications

References 11 publications

Intraocular Pressure in Patients With Uveitis Treated With Fluocinolone Acetonide Implants

Intraocular Pressure in Patients With Uveitis Treated With Fluocinolone Acetonide Implants

Current awareness: Pharmacoepidemiology and drug safety

Pars Plana Vitrectomy, Fluocinolone Acetonide Implantation, and Silicone Oil Infusion for the Treatment of Chronic, Refractory Uveitic Hypotony

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