Therapies in Autoimmune Peripheral Neuropathies beyond Intravenous Immunoglobulin, Plasma Exchange and Corticosteroids: An Analytical Review

Sivadasan, Ajith; Bril, Vera

doi:10.1016/j.tmrv.2022.05.002

Cited by 5 publications

(4 citation statements)

References 87 publications

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“…However, we are unable to comment on the optimal IVIG frequency in children using our study results. We anticipate the use of above‐mentioned outcome measures in future clinical trials investigating IVIG, PLEX, and novel immunomodulatory therapies in children with CIDP 21,34,35 …”

Section: Discussionmentioning

confidence: 99%

“…use of above-mentioned outcome measures in future clinical trials investigating IVIG, PLEX, and novel immunomodulatory therapies in children with CIDP. 21,34,35 The limitations in this study include retrospective study design and lack of healthy age-and sex-matched controls to compare the grip strength. When using a dynamometer in young children, variables to be considered include hand size, ability to follow directions, and monitoring for compensations at the shoulder, elbow, or wrist that could potentially impact reliability.…”

Section: Conflict Of Interest Statementmentioning

confidence: 99%

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Outcome measures in pediatric chronic inflammatory demyelinating polyradiculoneuropathy

Guttikonda,

Ahmad,

Goyal

et al. 2024

Muscle and Nerve

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Introduction/AimsObjective outcome measures in children undergoing treatment for chronic inflammatory demyelinating polyradiculoneuropathy (CIDP) are lacking. The aim of the study was to record serial grip strength and motor nerve conduction studies to assess interval change.MethodsThis was a retrospective review of 16 children (8 females and 8 males; median age, 9.7 years; interquartile range, 6–13 years) with CIDP followed at a tertiary children's hospital from 2013 to 2021. Subjects were treated with intravenous immunoglobulin (IVIG). Right and left grip strength measurements were obtained at each clinic visit using a handheld dynamometer. Annual right median motor nerve conduction study data were recorded during the study period.ResultsMean duration of follow‐up was 2.9 years. Grip strength (right: 0.19 kg/month, p < 0.001; left 0.23 kg/month, p < 0.001) and median F‐wave latencies (−0.23/month, p = 0.015) showed significant improvement over time. Akaike information criterion showed time + IVIG frequency <21 days as best fit for grip strength and distal compound muscle action potential amplitude.DiscussionOur study results indicate serial grip strength measurements are a feasible and objective way to assess motor strength improvement in children with CIDP receiving immunotherapy.

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Section: Discussionmentioning

confidence: 99%

Section: Conflict Of Interest Statementmentioning

confidence: 99%

Outcome measures in pediatric chronic inflammatory demyelinating polyradiculoneuropathy

Guttikonda,

Ahmad,

Goyal

et al. 2024

Muscle and Nerve

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“…Immunoglobulins are Y-shaped glycoproteins. They belong to the adaptive immune system and perform a wide range of effector functions that are essential for humoral immunity [ 16 ]. The most common type in the circulatory system, immunoglobulin G (IgG), is highly involved in the adaptive immune response.…”

Section: Introductionmentioning

confidence: 99%

Neutrophil Depletion Changes the N-Glycosylation Pattern of IgG in Experimental Murine Sepsis

Yaykasli,

van Schie,

Toes

et al. 2024

IJMS

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Sepsis is a life-threatening condition with a rising disease burden worldwide. It is a multifactorial disease and is defined as a dysregulated host response to infection. Neutrophils have been shown to be involved in the pathogenesis of sepsis by exacerbating inflammation. However, the exact effector mechanism of action still remains a mystery. Changes in the glycosylation pattern of the immunoglobulin G (IgG) Fc region are described for several diseases including meningococcal sepsis. In this study, we investigated the possible contribution of neutrophils and neutrophil implication, potentially related to degranulation or neutrophil extracellular trap (NET) formation in changing the IgG Fc N-glycosylation pattern in a murine sepsis model. We have measured the serum level of cytokines/chemokines and immunoglobulins, the serum activity of neutrophil elastase (NE), and analyzed the IgG Fc glycosylation pattern by Liquid Chromatography-Electrospray Ionization-Mass Spectrometry (LC-ESI-MS) and Lectin enzyme-linked immunosorbent assay (ELISA). We observed an increased activity of NE- and neutrophil-associated cytokines such as keratinocyte chemoattractant (KC) with the development of sepsis. Regarding the IgG Fc N-glycosylation, we observed an increase in fucosylation and α1,3-galactosylation and a decrease for sialyation. Interestingly, these changes were not uniform for all IgG subclasses. After depletion of neutrophils, we saw a change in the exposure of fucose and α2,6-linked sialic acid during the time course of our experimental sepsis model. In conclusion, neutrophils can influence changes in the IgG glycosylation pattern in experimental sepsis.

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“…Molecular mimicry between the lipopolysaccharides of the infectious organism and the glycosphingolipids or similar nerve antigens in our body triggers the immune response. [ 1 ]…”

mentioning

confidence: 99%

COVID-19, Vaccine, and Guillain–Barré Syndrome: Association or Causation

Agarwal

Srivastava

Vishnu

2023

Annals of Indian Academy of Neurology

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Therapies in Autoimmune Peripheral Neuropathies beyond Intravenous Immunoglobulin, Plasma Exchange and Corticosteroids: An Analytical Review

Cited by 5 publications

References 87 publications

Outcome measures in pediatric chronic inflammatory demyelinating polyradiculoneuropathy

Outcome measures in pediatric chronic inflammatory demyelinating polyradiculoneuropathy

Neutrophil Depletion Changes the N-Glycosylation Pattern of IgG in Experimental Murine Sepsis

COVID-19, Vaccine, and Guillain–Barré Syndrome: Association or Causation

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