Therapy for Cerebral Ischemic Injury with Erythropoietin-Containing Nanoparticles

He, Nongyue; Wang, Ting; Jiang, Li; Wang, Daxin; Hu, Yan; Zhang, Long

doi:10.1166/jnn.2010.3032

Cited by 16 publications

(11 citation statements)

References 26 publications

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“…These formulations contain chemotherapeutic agents inside the vehicle, resulting in better drug penetration into tumor tissue and less toxicity. Biodegradable polymeric nanoparticles are often used to achieve controlled release of drugs in advanced anticancer drug delivery systems 63–66. Further, some biodegradable polymer-derived drug delivery systems, such as nanoparticles delivering anticancer agents, are commercially available 67.…”

Section: Conp Prospects In Cancer Treatmentmentioning

confidence: 99%

Cerium oxide nanoparticles in cancer

Gao¹,

Chen²,

Ma³

et al. 2014

OTT

153

106

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With the development of many nanomedicines designed for tumor therapy, the diverse abilities of cerium oxide nanoparticles (CONPs) have encouraged researchers to pursue CONPs as a therapeutic agent to treat cancer. Research data have shown CONPs to be toxic to cancer cells, to inhibit invasion, and to sensitize cancer cells to radiation therapy and chemotherapy. CONPs also display minimal toxicity to normal tissues and provide protection from various forms of reactive oxygen species generation. Differential cytotoxicity is important for anticancer drugs to distinguish effectively between tumor cells and normal cells. The antioxidant capabilities of CONPs, which enable cancer therapy protection, have also resulted in the exploration of these particles as a potential anticancer treatment. Taken together, CONPs might be a potential nanomedicine for cancer therapy and this review highlights the current research into CONPs as a novel therapeutic for the treatment of cancer.

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Section: Conp Prospects In Cancer Treatmentmentioning

confidence: 99%

Cerium oxide nanoparticles in cancer

Gao¹,

Chen²,

Ma³

et al. 2014

OTT

153

106

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“…Recently, the nano-sized preparations 1 have attracted much attention due to the ability of nanoparticles, [2][3][4] nanocapsules, 5-6 micelles 7-9 and liopsomes 10 to act as a nanoreservoir for a variety of therapeutic agents including macromolecule drugs [11][12][13] and small molecular drugs. [14][15][16] Thereinto, amphiphilic copolymers micellar carriers with hydrophobic inner core has been widely investigated during the last two decades.…”

Section: Introductionmentioning

confidence: 99%

Micelles Based on Methoxy Poly(Ethylene Glycol)Cholesterol Conjugate for Controlled and Targeted Drug Delivery of a Poorly Water Soluble Drug

He²,

Yu³

et al. 2012

Journal of Biomedical Nanotechnology

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In this study, quercetin (QC) with cancer chemoprevention effect and anticancer potential was loaded into polymeric micelles of methoxy poly(ethylene glycol)-cholesterol conjugate (mPEG-Chol) in order to increase its water solubility. MPEG-Chol with lower critical micelle concentration (CMC) value (4 0 × 10 −7 M ∼ 13 × 10 −7 M) was firstly synthesized involving two steps of chemical modification on cholesterol by esterification, and then QC was incorporated into mPEG-Chol micelles by self-assembly method. After the process parameters were optimized, QC-loaded micelles had higher drug loading (3.66%) and entrapment efficiency (93.51%) and nano-sized diameter (116 nm). DSC analysis demonstrated that QC had been incorporated non-covalently into the micelles and existed as an amorphous state or a solid solution in the polymeric matrix. The freeze-dried formulation with addition of 1% (w/v) mannitol as cryoprotectant was successfully developed for the long-term storage of QC-loaded micelles. Compared to free QC, QC-loaded micelles could release QC more slowly. Moreover, the release of QC from micelles was slightly faster in PBS at pH 5 than that in PBS at pH 7.4, which implied that QC-loaded micelles might be pH-sensitive and thereby selectively deliver QC to tumor tissue with unwanted side effects. Therefore, mPEG-Chol was a promising micellar vector for the controlled and targeted drug delivery of QC to tumor and QCloaded micelles were also worth being further investigated as a potential formulation for cancer chemoprevention and treatment.

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“…After transient intrauterine ischemia, Epo reduces white matter injury as evidenced by myelin preservation in neonatal rats (Mazur et al, 2010). In addition, Epo-containing nanoparticles can ameliorate drug-induced liquefaction in a model of PVL (He et al, 2010).…”

Section: Protecting the White Mattermentioning

confidence: 99%