Therapy for chronic viral hepatitis: current indications, optimal therapies and delivery of care

Cowan, Matthew; Thomas, Howard; Foster, Graham R.

doi:10.7861/clinmedicine.11-2-184

Cited by 2 publications

(2 citation statements)

References 15 publications

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“…There is a need to formulate more potent, side-effect free therapeutics for treatment of viral hepatitis cases ( Cowan et al, 2011 ). Controlled zinc supplementation is known to be a safe, side effect free therapy against Wilson’s disease ( Brewer et al, 2000 ).…”

Section: Antiviral Effect Of Zinc On Hepatitis Virusesmentioning

confidence: 99%

Antiviral activity of zinc against hepatitis viruses: current status and future prospects

Kumar,

Ansari,

Narayanan

et al. 2023

Front. Microbiol.

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Viral hepatitis is a major public health concern globally. World health organization aims at eliminating viral hepatitis as a public health threat by 2030. Among the hepatitis causing viruses, hepatitis B and C are primarily transmitted via contaminated blood. Hepatitis A and E, which gets transmitted primarily via the feco-oral route, are the leading cause of acute viral hepatitis. Although vaccines are available against some of these viruses, new cases continue to be reported. There is an urgent need to devise a potent yet economical antiviral strategy against the hepatitis-causing viruses (denoted as hepatitis viruses) for achieving global elimination of viral hepatitis. Although zinc was known to mankind for a long time (since before Christ era), it was identified as an element in 1746 and its importance for human health was discovered in 1963 by the pioneering work of Dr. Ananda S. Prasad. A series of follow up studies involving zinc supplementation as a therapy demonstrated zinc as an essential element for humans, leading to establishment of a recommended dietary allowance (RDA) of 15 milligram zinc [United States RDA for zinc]. Being an essential component of many cellular enzymes and transcription factors, zinc is vital for growth and homeostasis of most living organisms, including human. Importantly, several studies indicate potent antiviral activity of zinc. Multiple studies have demonstrated antiviral activity of zinc against viruses that cause hepatitis. This article provides a comprehensive overview of the findings on antiviral activity of zinc against hepatitis viruses, discusses the mechanisms underlying the antiviral properties of zinc and summarizes the prospects of harnessing the therapeutic benefit of zinc supplementation therapy in reducing the disease burden due to viral hepatitis.

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Section: Antiviral Effect Of Zinc On Hepatitis Virusesmentioning

confidence: 99%

Antiviral activity of zinc against hepatitis viruses: current status and future prospects

Kumar,

Ansari,

Narayanan

et al. 2023

Front. Microbiol.

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“…4 For some years now, patients have been able to benefit from medical interventions that may reduce the risk of developing end-stage liver disease and also improve long-term survival, even if this goal is often achieved with continuous antiviral treatment. 5 In the meantime, the World Health Organization and other international scientific societies have issued and updated a number of recommendations to increase the awareness of HBV and HCV infections among health care providers and to contribute to the prevention and management of these infections. [6][7][8] Unfortunately, despite attempts to ensure that the medical community has access to this growing knowledge there is still a high frequency of patients with liver cirrhosis who require hospitalization on Internal Medicine wards because of complications, including the development of hepatocellular carcinoma (HCC), without any evidence of previous management of their liver disease.…”

Section: Introductionmentioning

confidence: 99%

Compliance with the clinical practice guidelines for the management of hepatitis B and C virus-related chronic liver disease: a survey based on hospitalized cirrhotic patients

Spada

Augello²,

Anastasi³

et al. 2013

Ital J Med

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In recent years, significant progress has been made in furthering our knowledge of chronic liver disease (CLD) and evaluating the therapeutic approaches. These have been updated in the form of recommendations by international scientific societies. Through a retrospective analysis, this study aimed to verify whether these recommendations have been applied in real practice. The study design included data gathered from all patients consecutively hospitalized for decompensated liver cirrhosis during one year. A pre-made master form was used to record data on the patients’ past knowledge of the etiology and management of their liver disease. As expected, hepatitis C virus (HCV) was the most frequent cause of CLD, while 41 cases were cryptogenic. In 69 of 263 patients with HCV infection, viral genotyping had been performed, although only 39 of these cases had been treated. Only 3 of 44 patients suffering from hepatitis B virus (HBV)-related liver cirrhosis had been treated in the past, while 11 patients were still being treated. Among the remaining patients, 15 were not aware that they had CLD and 15 had never been considered for antiviral treatment. In 81 cases, the disease had progressed to hepatocellular carcinoma, but only 19 patients had discovered the tumor following regular ultrasound screening. Thirty-seven patients were receiving specific treatment consistent with the stage of their disease. The management of HBV- and HCV-related CLD in Sicily is far from optimal, and although the natural history and management practices of these diseases are well known, this knowledge is a long way from being applied in our daily practice.

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Therapy for chronic viral hepatitis: current indications, optimal therapies and delivery of care

Cited by 2 publications

References 15 publications

Antiviral activity of zinc against hepatitis viruses: current status and future prospects

Antiviral activity of zinc against hepatitis viruses: current status and future prospects

Compliance with the clinical practice guidelines for the management of hepatitis B and C virus-related chronic liver disease: a survey based on hospitalized cirrhotic patients

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