Therapy for inoperable hepatocellular carcinoma with selective transarterial radioembolization with yttrium-90 microspheres

Abstract

Hepatocellular carcinoma is generally diagnosed at a late stage, which makes surgical treatment difficult. According to the Barcelona Clinic Liver Cancer (BCLC) staging system, patients with inoperable tumors can undergo transarterial chemoembolization or palliative therapy with sorafenib, their response rate does not exceed 30%. At the same time, the results of transarterial radioembolization (TARE) using yttrium-90-containing microspheres demonstrate an optimistic picture. In this paper, the authors systematize from expert positions the current data from the literature on the use of TARE to treat liver cancer in clinical practice and formulate prospects for using the technique in the Russian Federation. Based on the literature data, the authors demonstrate the superiority of TARE over sorafenib therapy and the results that are comparable with chemoembolization.

RADIOEMBOLIZATION AS A METHOD FOR THE TREATMENT OF UNRESECTABLE PRIMARY AND METASTATIC LIVER CANCER (LITERATURE REVIEW)

“…В последние два года РЭ стала широко применяться в крупных медицинских центрах в мире, в настоящее время данный метод лечения начал внедряться и в России [6,7,8].…”