Therapy For Intrauterine Growth Restriction: Current Options and Future Directions

Pollack, Raphael N.; Yaffe, Haim; Divon, Michael Y.

doi:10.1097/00003081-199712000-00017

Cited by 4 publications

(3 citation statements)

References 68 publications

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“…Intrauterine demise of the fetus will always involve mitochondrial energy failure. Therapeutic interventions that include bed rest [124], low dose aspirin [125], or conventional nutrient supplementation [126] have been shown to have limited success in reducing perinatal morbidity and mortality. Creatine supplementation of the maternal diet is consistent with conservative management and would not interfere with the increased surveillance of such high-risk patients that is now standard clinical practice.…”

Section: Reviewmentioning

confidence: 99%

Creatine supplementation during pregnancy: summary of experimental studies suggesting a treatment to improve fetal and neonatal morbidity and reduce mortality in high-risk human pregnancy

Dickinson

Ellery

Ireland

et al. 2014

BMC Pregnancy Childbirth

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While the use of creatine in human pregnancy is yet to be fully evaluated, its long-term use in healthy adults appears to be safe, and its well documented neuroprotective properties have recently been extended by demonstrations that creatine improves cognitive function in normal and elderly people, and motor skills in sleep-deprived subjects. Creatine has many actions likely to benefit the fetus and newborn, because pregnancy is a state of heightened metabolic activity, and the placenta is a key source of free radicals of oxygen and nitrogen. The multiple benefits of supplementary creatine arise from the fact that the creatine-phosphocreatine [PCr] system has physiologically important roles that include maintenance of intracellular ATP and acid–base balance, post-ischaemic recovery of protein synthesis, cerebral vasodilation, antioxidant actions, and stabilisation of lipid membranes. In the brain, creatine not only reduces lipid peroxidation and improves cerebral perfusion, its interaction with the benzodiazepine site of the GABAA receptor is likely to counteract the effects of glutamate excitotoxicity – actions that may protect the preterm and term fetal brain from the effects of birth hypoxia. In this review we discuss the development of creatine synthesis during fetal life, the transfer of creatine from mother to fetus, and propose that creatine supplementation during pregnancy may have benefits for the fetus and neonate whenever oxidative stress or feto-placental hypoxia arise, as in cases of fetal growth restriction, premature birth, or when parturition is delayed or complicated by oxygen deprivation of the newborn.

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Section: Reviewmentioning

confidence: 99%

Creatine supplementation during pregnancy: summary of experimental studies suggesting a treatment to improve fetal and neonatal morbidity and reduce mortality in high-risk human pregnancy

Dickinson

Ellery

Ireland

et al. 2014

BMC Pregnancy Childbirth

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show abstract

“…einer Senkung der perinatalen Mortalität zeigten, hat keine dieser Therapien praktische Bedeutung erlangt [13]. einer Senkung der perinatalen Mortalität zeigten, hat keine dieser Therapien praktische Bedeutung erlangt [13].…”

Section: Therapieansätzeunclassified

Untitled

Crombach¹,

Tandu-Umba²

2001

Der Gynäkologe

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“…Impaired fetal growth can result from fetal causes (e.g., major congenital anomalies, congenital infections), placental pathology (e.g., abnormal cord insertions, abruptio placenta), and maternal factors (e.g., poor diet, smoking, environmental exposures), which can be inter-related with each other (3). Adequate uteroplacental hemodymamics and fetal tissue oxygenation are crucial to the maintenance of normal fetal development and growth.…”

Section: Introductionmentioning

confidence: 99%

Effect of Maternal Asthma and Gestational Asthma Therapy on Fetal Growth

2007

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Asthma is a common chronic condition that might seriously complicate pregnancy and fetal development. This article provides a comprehensive review of the existing literature regarding the effect on fetal growth of maternal asthma and common asthma medications used during pregnancy, including short-and long-acting beta (2)-agonists, inhaled and oral corticosteroids, chromones, leukotriene receptor agonists, and theophylline. Evaluated outcomes of fetal growth include low birth weight, mean birth weight, small for gestational age, birth length and head circumference, and measures of asymmetrical growth retardation. Methodological and practical considerations related to safety of asthma medications in pregnancy and management of gestational asthma are discussed.

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Therapy For Intrauterine Growth Restriction: Current Options and Future Directions

Cited by 4 publications

References 68 publications

Creatine supplementation during pregnancy: summary of experimental studies suggesting a treatment to improve fetal and neonatal morbidity and reduce mortality in high-risk human pregnancy

Creatine supplementation during pregnancy: summary of experimental studies suggesting a treatment to improve fetal and neonatal morbidity and reduce mortality in high-risk human pregnancy

Untitled

Effect of Maternal Asthma and Gestational Asthma Therapy on Fetal Growth

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