Therapy-induced neuroplasticity in chronic aphasia

Marcotte, Karine; Adrover‐Roig, Daniel; Damien, Brigitte; Préaumont, Mathilde de; Généreux, Suzanne; Hubert, M.; Ansaldo, Ana Inés

doi:10.1016/j.neuropsychologia.2012.04.001

Cited by 82 publications

(59 citation statements)

References 84 publications

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“…However, based on previous data from older patients with aphasia who received intensive language therapy, it seems that patients benefit from treatment and show neuroplastic changes after therapy, irrespective of their age. (Breier et al, 2007; Marcotte et al, 2012; Sickert et al, 2014). Still, future research is necessary to clarify whether the present therapy-induced ERP changes to well-formed meaningful strings and partly meaningless strings conforming to a construction pattern can be replicated in a larger population and across age groups.…”

Section: Discussionmentioning

confidence: 99%

“…Unfortunately, neuroimaging studies on PSA indicate a fairly heterogeneous pattern of cortical reorganization that seems to be modulated by patient characteristics, type of SLT, the language task applied, and the neuroimaging method (Crosson et al, 2005; Saur et al, 2006; Marcotte et al, 2012). Previous studies led to somewhat inconsistent results with regard to the contribution of the left (LH) and right (RH) hemispheres to language recovery (Weiller et al, 1995; Heiss et al, 1999; Saur et al, 2006).…”

Section: Introductionmentioning

confidence: 99%

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Therapy-Induced Neuroplasticity of Language in Chronic Post Stroke Aphasia: A Mismatch Negativity Study of (A)Grammatical and Meaningful/less Mini-Constructions

Lucchese

Pulvermüller

Stahl

et al. 2017

Front. Hum. Neurosci.

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Clinical language performance and neurophysiological correlates of language processing were measured before and after intensive language therapy in patients with chronic (time post stroke >1 year) post stroke aphasia (PSA). As event-related potential (ERP) measure, the mismatch negativity (MMN) was recorded in a distracted oddball paradigm to short spoken sentences. Critical ‘deviant’ sentence stimuli where either well-formed and meaningful, or syntactically, or lexico-semantically incorrect. After 4 weeks of speech-language therapy (SLT) delivered with high intensity (10.5 h per week), clinical language assessment with the Aachen Aphasia Test battery demonstrated significant linguistic improvements, which were accompanied by enhanced MMN responses. More specifically, MMN amplitudes to grammatically correct and meaningful mini-constructions and to ‘jabberwocky’ sentences containing a pseudoword significantly increased after therapy. However, no therapy-related changes in MMN responses to syntactically incorrect strings including agreement violations were observed. While MMN increases to well-formed meaningful strings can be explained both at the word and construction levels, the neuroplastic change seen for ‘jabberwocky’ sentences suggests an explanation in terms of constructions. The results confirm previous reports that intensive SLT leads to improvements of linguistic skills in chronic aphasia patients and now demonstrate that this clinical improvement is associated with enhanced automatic brain indexes of construction processing, although no comparable change is present for ungrammatical strings. Furthermore, the data confirm that the language-induced MMN is a useful tool to map functional language recovery in PSA.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Therapy-Induced Neuroplasticity of Language in Chronic Post Stroke Aphasia: A Mismatch Negativity Study of (A)Grammatical and Meaningful/less Mini-Constructions

Lucchese

Pulvermüller

Stahl

et al. 2017

Front. Hum. Neurosci.

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“…Studies on repetitive transcranial magnetic stimulation (rTMS) and transcranial direct current stimulation (tDCS) have affirmed their beneficial effects on post-stroke aphasia recovery by inducing neuroplasticity of targeted brain areas (Holland et al 2011;Marcotte et al 2012;Volpato et al 2013;Allendorfer et al 2012;Kakuda et al 2011;Naeser et al 2005). In summary the type, duration, intensity and earlier commencement of aphasia therapy may be considered a determinant factor for better recovery (David et al 1982).…”

Section: Accepted Manuscriptmentioning

confidence: 99%

“…Therapeutic techniques like melodic intonation therapy (MIT), constraint induced therapy (CID), action observation treatment (AOT), and semantic feature analysis (SFA) tend to also facilitate neuroplasticity(Marcotte et al 2012;Martins et al 2013; Conklyn et al 2014; Koenig-bruhin et al 2013;Pulvermüller et al 2005). Pharmacological trials of donepezil and galantamine have shown some beneficial effects compared with placebos, as these drugs promote reorganization and increase in acetylcholine concentration(Berthier et al 2006;Hong et al 2012).…”

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confidence: 99%

Factors predicting post-stroke aphasia recovery

Watila

Balarabe²

2015

Journal of the Neurological Sciences

196

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“…Many studies completed in the last decades indicate that, whether they rely on functional reorganization, functional reactivation, or a combination of both, specific mechanisms underlie recovery, and these mechanisms can be enhanced by language therapy (Fridriksson et al, 2007;Marcotte et al, 2012;Marcotte et al, 2010;Meinzer et al, 2008;Meinzer et al, 2010;van Oers et al, 2010). The advent of neuroimaging techniques has allowed us to deepen our knowledge of these neuroplasticity mechanisms and of how specific therapies can trigger them, thus contributing to the recovery from aphasia.…”

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confidence: 99%

Recovery from anomia following Semantic Feature Analysis

Durand¹,

Ansaldo

2013

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Our previous work (Marcotte et al., 2012) reported neurofunctional changes associated with recovery from anomia following Semantic Feature Analysis (SFA) in a group of participants with moderate to severe chronic anomia, providing evidence of therapy-induced neuroplasticity in chronic aphasia. The activation patterns observed concurrently with the recovery of naming suggest that SFA triggers the recruitment of an alternative pathway involving the left precentral gyrus and the left inferior parietal lobule, both of which are part of the Mirror Neuron System (MNS). SFA's potential role in triggering the recruitment of the MNS is discussed, in line with Embodied Cognition Theory and other theoretical frameworks opening a window on aphasia therapy issues and the intricate links between motor and language processing. Neuroplasticity Underlying Recovery from AphasiaStroke is a major health problem with potentially devastating consequences. Approximately 30% of stroke survivors are left with a language dysfunction of some kind. Aphasia is a language impairment that leads to persistent disability. Recovery from aphasia depends upon adaptive brain plasticity -the brain's potential

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Therapy-induced neuroplasticity in chronic aphasia

Cited by 82 publications

References 84 publications

Therapy-Induced Neuroplasticity of Language in Chronic Post Stroke Aphasia: A Mismatch Negativity Study of (A)Grammatical and Meaningful/less Mini-Constructions

Therapy-Induced Neuroplasticity of Language in Chronic Post Stroke Aphasia: A Mismatch Negativity Study of (A)Grammatical and Meaningful/less Mini-Constructions

Factors predicting post-stroke aphasia recovery

Recovery from anomia following Semantic Feature Analysis

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