Therapy of Esophageal Carcinoma: Results from the Joint Group on Esophageal Carcinoma in Rotterdam

Andel, J.G. van; Dees, Jan; Eijkenboom, W. M. H.; Houten, Holly Van; Jobsen, Jan J.; Mud, H. J.; Obertop, H.; Putten, Wim L.J. van; Blankenstein, M. van; Schattenkerk, M. Eeftinck; Jong, P. C. De; Knegt, P.; Splinter, T. A. W.; Verweij, Jaap

doi:10.3109/02841868609136388

Cited by 4 publications

(1 citation statement)

References 22 publications

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“…This policy was based on studies in which a combined modality treatment strategy of preoperative radiation therapy and surgery was used for patients with esophageal cancer, suggesting superiority to surgery alone 5 . 6 Until 1987, post‐operative radiation therapy was administered to patients with a T3 or T4 tumor status and patients with positive lymph nodes or residual tumor at the resection margins. Later prospective studies showed no beneficial effects of pre‐ or post‐operative radiation therapy on recurrence of disease or on survival after resection of a carcinoma of the esophagus or the cardia 7 –9 .…”

Section: Methodsmentioning

confidence: 99%

Recurrence and survival after resection of adenocarcinoma of the gastric cardia

Stassen

Bosman

Siersema

et al. 2000

Diseases of the Esophagus

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In a retrospective study, the results after resection of carcinoma of the gastric cardia in the era without neoadjuvant therapy or extended lymph node dissection were evaluated. All 184 patients who underwent resection between January 1983 and December 1993 were included. Recurrence of disease, survival and prognostic factors were determined. The overall cumulative 5-year recurrence rate was 71% and the survival rate 23%. Multivariate analysis identified locoregional lymph node and distant metastases as the crucial prognosticators of recurrence of disease and survival. These results were similar to those from a previous study concerning our patients operated during the years 1983-88. The prognosis of a resected cardiacarcinoma has remained unchanged in our hands over the past 10 years. These results stress the importance of exploring new ways, such as the use of new diagnostic tools, to optimize preoperative patient selection and more aggressive treatment regimens to improve final outcome.

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Section: Methodsmentioning

confidence: 99%