Therapy of Oral and Cutaneous Dryness Manifestations in Sjögren’s Syndrome

Fox, Robert I.; Fox, Carla M.

doi:10.1007/978-0-85729-947-5_36

Cited by 3 publications

(5 citation statements)

References 90 publications

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“…Since salivary gland ductal cells are sensitive to extracellular [Ca 2+ ] [ 46 ], further study is warranted to determine the minimum CaCl 2 concentration needed to ensure the stability of alginate microtubes during long-term cell culture and to maintain normal salivary gland function. Since the calcium concentration in saliva is in the range of 1.2 mM–2.8 mM [ 47 ], in future studies, we will determine if 1 mM–2 mM CaCl 2 medium supplementation is sufficient to stabilize the alginate hydrogel microtube during culture. We will also examine the feasibility of using Ba 2 + to stabilize the alginate hydrogel microtube since Ba 2 + yields the most stable alginate hydrogel relative to other divalent cations [ 48 ].…”

Section: Discussionmentioning

confidence: 99%

Alginate Hydrogel Microtubes for Salivary Gland Cell Organization and Cavitation

et al. 2022

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Understanding the different regulatory functions of epithelial and mesenchymal cell types in salivary gland development and cellular organization is essential for proper organoid formation and salivary gland tissue regeneration. Here, we demonstrate a biocompatible platform using pre-formed alginate hydrogel microtubes to facilitate direct epithelial–mesenchymal cell interaction for 3D salivary gland cell organization, which allows for monitoring cellular organization while providing a protective barrier from cell-cluster loss during medium changes. Using mouse salivary gland ductal epithelial SIMS cells as the epithelial model cell type and NIH 3T3 fibroblasts or primary E16 salivary mesenchyme cells as the stromal model cell types, self-organization from epithelial–mesenchymal interaction was examined. We observed that epithelial and mesenchymal cells undergo aggregation on day 1, cavitation by day 4, and generation of an EpCAM-expressing epithelial cell layer as early as day 7 of the co-culture in hydrogel microtubes, demonstrating the utility of hydrogel microtubes to facilitate heterotypic cell–cell interactions to form cavitated organoids. Thus, pre-formed alginate microtubes are a promising co-culture method for further understanding epithelial and mesenchymal interaction during tissue morphogenesis and for future practical applications in regenerative medicine.

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Section: Discussionmentioning

confidence: 99%

Alginate Hydrogel Microtubes for Salivary Gland Cell Organization and Cavitation

et al. 2022

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“…Penurunan aktivitas kelenjar ini menyebabkan berkurangnya keringat dan kulit kering. 13,15,16 Xeroderma pada umumnya disertai keluhan gatal, terbakar, dan rasa seperti tertusuk. Garukan akibat rasa gatal dapat menyebabkan trauma pada kulit dan selanjutnya dapat terjadi perubahan kulit kronis yang ditandai dengan hiperpigmentasi.…”

Section: Xerodermaunclassified

“…17,18 Penggunaan obat anti kolinergik pada malam hari dapat mengganggu tidur karena rasa kering pada mulut yang membuat pasien minum terus menerus sehingga poliuria dan menyebabkan kelelahan pada pagi hari. 16 American Dental Association merekomendasikan untuk menghindari sukrosa, minuman berkarbonisasi, jus, dan minuman yang mengandung pemanis. Kopi, alkohol, dan nikotin sebaiknya juga dihindari karena dapat meningkatkan risiko karies.…”

Section: A Xerostomia Nonfarmakologi (Loe 5)unclassified

“…Kopi, alkohol, dan nikotin sebaiknya juga dihindari karena dapat meningkatkan risiko karies. 16 Selain itu, hidrasi yang cukup merupakan salah satu cara efektif dalam mencegah kekeringan mulut dan tidak membutuhkan biaya besar. Meminum air dalam jumlah sedikit secara berkala dilaporkan sebagai metode efektif untuk tata laksana xerostomia.…”

Section: A Xerostomia Nonfarmakologi (Loe 5)unclassified

“…Pencegahan karies dentis pada pasien SS merupakan hal yang penting karena tingginya insidensi karies dentis dan penyakit periodontal. 16 American Dental Association menyarankan individu yang berisiko tinggi mendapat karies dentis sebaiknya mendapatkan fluoride varnish dan gel setiap 3 hingga 6 bulan. 17 Fluoride diketahui dapat menghambat metabolisme bakteri, menurunkan ambang batas larutnya enamel terhadap asam sehingga karies dentis tidak mudah terbentuk.…”

Section: Fluoride (Loe 2)unclassified

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Penatalaksanaan Paripurna Sindrom Sjögren

Respati

Budianti

2021

J. Kdokt Meditek

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Sindrom Sjögren (SS) adalah penyakit autoimun yang ditandai dengan infiltrasi limfosit pada kelenjar eksokrin dan menyebabkan sindrom sika. Patogenesis SS masih belum diketahui sepenuhnya namun diduga terdapat kerusakan epitel kelenjar eksokrin karena peningkatan respons sel B dan sel T terhadap autoantigen Ro (SS-A) dan La (SS-B). Manifestasi klinis SS dibedakan menjadi glandular dan ekstraglandular. Tatalaksana SS terdiri atas lokal dan sistemik yang bertujuan untuk meningkatkan kualitas hidup dengan mengurangi gejala kekeringan.

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Diagnostic performance of serology against histologic assessment to diagnose Sjögren’s syndrome

Costa¹

2021

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Therapy of Oral and Cutaneous Dryness Manifestations in Sjögren’s Syndrome

Cited by 3 publications

References 90 publications

Alginate Hydrogel Microtubes for Salivary Gland Cell Organization and Cavitation

Alginate Hydrogel Microtubes for Salivary Gland Cell Organization and Cavitation

Penatalaksanaan Paripurna Sindrom Sjögren

Diagnostic performance of serology against histologic assessment to diagnose Sjögren’s syndrome

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