Therapy of Oral Lichen Planus with Monochromatic Excimer Light

Abstract

Oral lichen planus can cause considerable inconvenience to the patient and is often resistant to the various therapeutic options used, tending to become chronic. The monochromatic excimer light 308 nm is UVB radiation generated and has already been used with good results in the treatment of psoriasis, vitiligo and, less frequently, lichen cutaneous. The purpose of this study is to assess the clinical efficacy of monochromatic excimer light in the treatment of symptomatic oral lichen planus. Twenty patients were treated weekly with single phototherapic sessions. The therapy was suspended on achieving a total score of gravity at least 35% or less than the score of departure. At the end of the study scoring on the size of lesions, intensity of white, intensity of erythema, grade of sick oral gingiva, for both gingival and non-gingival lichen was improved. The statistical processing found a highly significant reduction in post-therapy (p< 0002) of all subjective manifestations tested. Side effects were not observed. Our study shows that monochromatic excimer light 308 nm would appear to be an effective and well-tolerated treatment for oral lichen planus and could represent a new additional therapeutic strategy.

Microarray Analysis of NF-κB Signaling Pathways in PBMC of Mice Infected by Trichinella Spiralis

“…A previous study of the cDNA microarray analysis (1176 genes) suggested that many genes associated with cell differentiation, proliferation, cycle regulation, transformation and apoptosis are likely involved during T. spiralis infection (19). Further studies have confirmed that several signal pathways participate in the processes, such as the transforming growth factor (TGF)-beta signal in cell cycle arrest and transformation (20)(21)(22), myogenic regulatory factors in satellite cell activation and differentiation (23), mitochondriamediated (24)(25)(26)(27) and TNF-alpha signal pathways (28)(29)(30)(31) in apoptosis. However, to date, little is known concerning the NF-KB signaling pathway.…”

IL-31 a TH2 Cytokine Involved in Immunity and Inflammation

“…Recent studies revealed that IL-31 stimulates inflammatory responses in myofibroblasts and induces the generation of chemokines such as IL-8, GRO-u, MCP-3, CXCL3, CCLl3, CCLl5, IL-6, IL-16 and IL-32, and matrix metalloproteinases (MMP-I, MMP-3, MMP-25 and MMP-7) (14). In epithelial cells, IL-31 can activate p38 MAPK, ERK and JNK, and also increases protein expressions of epidermal growth factor (EGF), vascular endothelial growth factor (VEGF) and MCP-I (39)(40)(41)(42)(43)(44)(45)(46)(47)(48)(49)(50).…”