Therapy-related,<i>mixed-lineage leukaemia</i>translocation-positive, monoblastic myeloid sarcoma of the uterus

Pullarkat, Vinod; Veliz, Leslie; Chang, Karen L.; Mohrbacher, Ann; Teotico, A.L.; Forman, Stephen J.; Slovak, Marilyn L.

doi:10.1136/jcp.2005.033266

Cited by 8 publications

(3 citation statements)

References 12 publications

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“… FIP1L1- PDGFRA rearrangement NA NA [ 7 ] 8 4 m NA Skin NA 0.245 for primary monocytes and juvenile monocytes S-100, CD68, CD4, CD56, CD123, CD163, Ki-67(40%) CD1, CD21, MPO NA NA NA 10 [ 8 ] 9 49 F Uterus Leukemia NA CD15, CD43, CD45, CD68, Lysozyme, Ki-67(70%) CD3, CD5, CD10, CD20, CD34, CD79a, CD117, CK, TdT, MPO Chemo. (cytarabine and idarubicin) MLL gene rearrangement NA NA [ 9 ] 10 2 M Lower jaw Primary No abnormalities CD45, CD68, Lysozyme CD3, CD20, CD99, TdT, MPO, CD138 Chemo. (cytarabine and anthracyclines) NA NA NA [ 10 ] Chemo Chemotherapy, F Female, M Male, m Month, NA Not applicable, Radio Radiotherapy …”

Section: Discussionmentioning

confidence: 99%

Exome sequencing analysis of gastric primary myeloid sarcoma with monocytic differentiation with altered immunophenotype after chemotherapy: case report

Zhang²,

Cui³

et al. 2023

Diagn Pathol

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Background Myeloid Sarcoma with monocytic differentiation is rare and quite likely is missed by surgical pathologists. However it is frequently misdiagnosed because of its non-specific imaging and histological pattern. Case presentation We report the case of a 64-year-old woman with gastric primary myeloid sarcoma with monocytic differentiatio. Upper endoscopy revealed a neoplastic growth at the junction of the lesser curvature and gastric antrum. Except for a slightly increased peripheral monocyte count, no abnormalities were found on hematological and bone-marrow examination. Gastroscopic biopsy showed poorly differentiated atypical large cells with visible nucleoli and nuclear fission. Immunohistochemistry showed positive CD34, CD4, CD43, and CD56 expression, and weakly positive lysozyme expression. Immune markers for poorly differentiated adenocarcinoma, malignant melanoma, and lymphohematopoietic-system tumors were negative. The final diagnosis was myeloid sarcoma with monocytic differentiation. Chemotherapy did not shrink the tumor, so, radical surgery was performed. Although the tumor morphology did not change postoperatively, the immunophenotype did. CD68 and lysozyme expression (tumor tissue markers) changed from negative and weakly positive to strongly positive, AE1/3 expression (epithelial marker) changed from negative to positive, and CD34, CD4, CD43, and CD56 expression (common in naive hematopoietic cell-derived tumors) was greatly attenuated. Exome sequencing revealed missense mutations in FLT3 and PTPRB, which are associated with myeloid sarcoma, and in TP53, CD44, CD19, LTK, NOTCH2, and CNTN2, which are associated with lymphohematopoietic tumors and poorly differentiated cancers. Conclusion We diagnosed myeloid sarcoma with monocytic differentiation after excluding poorly differentiated adenocarcinoma, common lymphohematopoietic-system tumors, epithelioid sarcoma, and malignant melanoma. We identified that the immunophenotypic of patient had alterations after chemotherapy, and FLT3 gene mutations. We hope that the above results will improve our understanding of this rare tumor.

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Section: Discussionmentioning

confidence: 99%

Exome sequencing analysis of gastric primary myeloid sarcoma with monocytic differentiation with altered immunophenotype after chemotherapy: case report

Zhang²,

Cui³

et al. 2023

Diagn Pathol

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“…In isolated EMS cases, bone marrow involvement is observed within 2 years (2, 7). Immunohistochemistry testing remains essential for making the right diagnosis of EMS (1,5). Hence, the most common positive markers include CD68, CD34, CD43, lysozyme, etc.…”

Section: Discussionmentioning

confidence: 99%

“…Mediastinal involvement is reported only in a few cases (3,4). Rarely, it occurs in patients without the manifestation of acute leukemia in blood and bone marrow (1)(2)(3)(4)(5). There are no age limits, but it is still more prevalent in children younger than 15 years (1).…”

Section: Introductionmentioning

confidence: 99%