Therapy with angiotensin-converting enzyme inhibitors, angiotensin II receptor blockers, and statins: No effect on ablation outcome after ablation of atrial fibrillation

Richter, Bernhard; Derntl, Michael; Marx, Manfred; Lercher, Peter; Gössinger, Heinz

doi:10.1016/j.ahj.2006.09.006

Cited by 78 publications

(58 citation statements)

References 32 publications

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“…This finding suggests that a systemic anti-inflammatory strategy may not be appropriate for therapeutic intervention after radiofrequency maze procedure adjunct to mitral valve surgery. Our finding is supported by the clinical observation that the routine use of statins, angiotensin converting enzyme inhibitor or type I angiotensin II receptor blocker do not improve outcomes of AF catheter ablation [17].…”

Section: Discussionsupporting

confidence: 77%

Plasma C-Reactive Protein Is Not Related to Sinus Non-Conversion by Maze Procedure Adjunct to Mitral Valve Surgery

Chen¹,

Liu²,

Chang

et al. 2012

Disease Markers

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Abstract. In Framingham cohort study, C-reactive protein was not associated with incident atrial fibrillation (AF) after adjustment for left atrial size. This study examined whether levels of plasma inflammatory markers would be significant risk factors for failed maze procedure for AF. This study enrolled 88 patients with mitral valve disease undergoing valve surgery (n = 32, sinus control group) or concomitant maze procedure for persistent atrial fibrillation (AF) (n = 56, AF group). The mean follow-up in the AF group was 55.0 ± 17.5 months. The AF and sinus control groups did not differ in preoperative levels of C-reactive protein (p = 0.636). In the AF group receiving maze procedure, the sinus conversion (n = 37) and non-conversion (n = 19) groups did not significantly differ in preoperative levels of interleukin-6 (p = 0.607) and tumor necrosis factor-α (p = 0.379). In multivariate analysis after adjustment for preoperative plasma inflammatory markers, independent factors associated with sinus conversion were AF duration (p = 0.003), and left atrial area (p = 0.014). In conclusion, plasma inflammatory markers are not associated with sinus non-conversion by radiofrequency maze procedure.

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Section: Discussionsupporting

confidence: 77%

Plasma C-Reactive Protein Is Not Related to Sinus Non-Conversion by Maze Procedure Adjunct to Mitral Valve Surgery

Chen¹,

Liu²,

Chang

et al. 2012

Disease Markers

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“…6,8,[16][17][18][19] On the other hand, a suppressive effect of RASIs on AF recurrences after PVI was demonstrated in patients with a relatively small LA. 15,20 The present study showed that the use of RASIs was closely associated with the AF recurrence-free rates in the patients with a non-dilated LA, but not at all in the patients with a dilated LA.…”

Section: La Size and Fibrosismentioning

confidence: 99%

“…[16][17][18][19][20][21] A few retrospective trials have demonstrated that the routine use of statins, ACEIs or ARBs did not improve the outcome of AF ablation among patients with drug-resistant paroxysmal or persistent. 16,17 Tayebjee et al also recently identified that RASIs had no beneficial effect on the long-term sinus maintenance after catheter ablation of PAF and PerAF. 18 Zheng et al showed that RASIs could not prevent AF recurrences in patients with chronic AF.…”

Section: Effect Of Rasis On Af Recurrences As Compared With Previous mentioning

confidence: 99%

Renin–angiotensin system inhibitors can suppress atrial fibrillation recurrence after encircling ipsilateral pulmonary vein isolation in patients with a non-dilated left atrium

Takigawa

Yamada

Yoshida

et al. 2012

J Renin Angiotensin Aldosterone Syst

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Introduction: The purpose of this study was to investigate whether the effects of renin-angiotensin system inhibitors (RASIs) after encircling ipsilateral pulmonary veins isolation (EIPVsI) for atrial fibrillation (AF) differed between patients with non-dilated and dilated left atria. Materials and methods: We retrospectively studied 292 consecutive patients (mean age=61±11 years, 75% males) who underwent successful EIPVsI for paroxysmal or persistent AF. RASIs' effects were compared between the patients with a non-dilated left atrium of <40 mm (n=178) and dilated left atrium of ≥40 mm (n=114). Results: During a mean follow-up period of 18.9±12.7 months, AF recurred in 38 (21.4%) and 45 (39.5%) patients with non-dilated and dilated left atria, respectively. A multivariate Cox proportional analysis revealed that treatment with RASIs (hazard ratio (HR) 0.30, 95% confidence interval (CI) =0.13-0.66, p=0.003), the duration of AF (HR 1.08/year, 95% CI=1.01-1.16, p=0.03), a history of hypertension (HR 2.86, 95% CI=1.21-6.85, p=0.02) and the left ventricular ejection fraction (HR 0.54/10%↑, 95% CI=0.34-0.87, p=0.01) were associated with AF recurrences in patients with a non-dilated left atrium. On the other hand, only the duration of AF (HR 1.11/year, 95% CI=1.01-1.21, p=0.03) was associated with AF recurrences in those with a dilated LA, and RASIs had no effect on AF recurrences (p=0.65). Conclusions: RASIs suppressed AF recurrences after EIPVsI only in patients with a non-dilated left atrium.

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“…4,5 Although the exact cause and mechanism of AF following cardiac surgery have not been testified, inflammatory component of this postoperative arrhythmia has been verified by several articles. 6,7 Statin drugs, which have both antioxidant and antiinflammatory properties, have showed efficacy in attenuating postoperative AF and may constitute a potential preventive approach [8][9][10] for postoperative arrhythmia.…”

Section: 3mentioning

confidence: 99%

Effect of Statins in Preventing Postoperative Atrial Fibrillation Following Cardiac Surgery

Liang¹,

Wang²,

Zhang³

et al. 2010

J.A.F.I.B

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Therapy with angiotensin-converting enzyme inhibitors, angiotensin II receptor blockers, and statins: No effect on ablation outcome after ablation of atrial fibrillation

Cited by 78 publications

References 32 publications

Plasma C-Reactive Protein Is Not Related to Sinus Non-Conversion by Maze Procedure Adjunct to Mitral Valve Surgery

Plasma C-Reactive Protein Is Not Related to Sinus Non-Conversion by Maze Procedure Adjunct to Mitral Valve Surgery

Renin–angiotensin system inhibitors can suppress atrial fibrillation recurrence after encircling ipsilateral pulmonary vein isolation in patients with a non-dilated left atrium

Effect of Statins in Preventing Postoperative Atrial Fibrillation Following Cardiac Surgery

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