Therapy with Etamsylate in Chronic Simple Glaucoma

Vojniković, Božidar

doi:10.1159/000306920

Cited by 2 publications

(2 citation statements)

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“…Lowering of the IOP by etamsylate in human subjects was reported by Vojnikovic [10] in 1973. Oral administration of 500 mg thrice daily for 4 weeks brought about a fall in IOP from a mean of 30 to a mean of 15 mm Hg in 72 of 100 patients with openangle glaucoma.…”

Section: Discussionmentioning

confidence: 68%

“…Inhibition of prostaglandin biosynthesis by etamsylate has been demonstrated in vitro in pregnant human myometrium [6] and in rabbit irisciliary body [2]. It has been found to lower intraocular pressure (IOP) in human sub jects with glaucoma [10], and in rabbits in which IOP has been raised experimentally by prostaglandins [3,4], and it also facili tates the outflow of aqueous humor [8].…”

Section: Introductionmentioning

confidence: 99%

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Etamsylate (Dicynone) Reduces Aqueous Humor Formation and Intraocular Pressure in Rabbits

Jozsa

1983

Ophthalmic Res

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The rate of aqueous humor production (measured by the clearance of ¹²⁵I-labeled albumin administered into the anterior chamber) and the intraocular pressure (measured via an electronic transducer) fell after subconjunctival injection of 37 mg (0.3 ml) of etamsylate (Dicynone) in rabbits. The differences between treated and untreated animals with respect to both variables were statistically significant. It is conjectured that the action of etamsylate in lowering intraocular pressure may be mediated at least in part by its reduction of aqueous humor formation.

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Section: Discussionmentioning

confidence: 68%