Therapy with Fluconazole for Tinea Corporis, Tinea Cruris, and Tinea Pedis

Abstract

We treated 20 patients who had tinea corporis and/or tinea cruris and 20 patients who had tinea pedis with oral fluconazole. All patients were given a single 150-mg dose of fluconazole upon entry into the study; at that time, and at each follow-up visit, clinical signs and symptoms were evaluated and mycological and laboratory examinations were performed. If clinical and/or mycological cure or significant improvement in a patient's condition was not evident at the 7-day follow-up visit, a second dose of fluconazole (150 mg) was given. A maximum of four doses, one week apart, were given. A long-term evaluation of the efficacy of fluconazole in the treatment of these infections was performed 28-30 days after the last dose was administered to each patient. For the treatment of tinea corporis and/or tinea cruris, 70% of patients required two doses, 20% required three doses, and 10% required four doses. At the long-term follow-up visit the clinical and mycological response rates were determined to be 95% cure and 5% relapse. For the treatment of tinea pedis, 20% of the patients required two doses, 20% required three doses, and 60% required four doses. For these patients, the long-term clinical response rates were 70% cure and 30% improvement; mycological response rates were 75% eradication, 10% persistence of infection, and 15% relapse. This treatment was well tolerated; no adverse effects or clinically significant laboratory abnormalities were reported.

A comparative study of mycological efficacy of terbinafine and fluconazole in patients of tinea corporis

“…2,3 An alternative is fluconazole which is given orally once a week for up to four consecutive weeks. 4,5 Fluconazole, a synthetic triazole derivative, is an azole antifungal agent. Terbinafine is an allylamine.…”

Dermatophytosis in Tulugudu Island, Ethiopia

“…It easily spreads among siblings and in schools [1,2]. Its prevalence is much higher in developing than in industrialized countries, because socio-economic factors, overcrowding, general hygiene and animal contact play an important role in transmission [3]. In Ethiopia, information about the prevalence of dermatophytoses has been limited [4].…”

A comparison of the efficacy of oral fluconazole, 150 mg/week versus 50 mg/day, in the treatment of tinea corporis, tinea cruris, tinea pedis, and cutaneous candidosis

“…This study confirms the findings of previous investigations that fluconazole is an effective, well‐tolerated antimycotic agent active against tinea corporis, tinea cruris, tinea pedis, and cutaneous candidosis in dosing regimens of 50 mg once daily or 150 mg once weekly. 1–6 There were no statistically significant differences in clinical or mycologic efficacy between 150‐mg once‐weekly and 50‐mg once‐daily fluconazole dosing regimen groups at the end of treatment or at follow‐up visits.…”