There and Back Again: Hippocampus and Retrosplenial Cortex Track Homing Distance during Human Path Integration

Chrastil, Elizabeth R.; Sherrill, Katherine R.; Hasselmo, Michael E.; Stern, Chantal E.

doi:10.1523/jneurosci.1209-15.2015

Cited by 112 publications

(147 citation statements)

References 74 publications

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“…Such a result fits with research that has indicated that connections between the MTL and visuo‐spatial cortical areas serve several goal‐directed spatial navigation functions. Some of this work has provided evidence that cross‐talk between these regions is needed to code for visual cues (e.g., optic flow) present in the external world in service of forming a spatial map (Brown, Hasselmo, & Stern, ; Chrastil, Sherrill, Hasselmo, & Stern, ; Sherrill et al, ). Our results suggest that this relationship is present even when forming mental simulations of spatial representations.…”

Section: Discussionmentioning

confidence: 99%

The medial temporal lobe functional connectivity patterns associated with forming different mental representations

Levine

2018

Hippocampus

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The medial temporal lobes (MTL), and more specifically the hippocampus, are critical for forming mental representations of past experiences-autobiographical memories-and for forming other "nonexperienced" types of mental representations, such as imagined scenarios. How the MTL coordinate with other brain areas to create these different types of representations is not well understood. To address this issue, we performed a task-based functional connectivity analysis on a previously published dataset in which fMRI data were collected as participants created different types of mental representations under three conditions. One condition required forming and relating together details from a past event (autobiographical task), another required forming and relating together details of a spatial context (spatial task) and another condition required relating together conceptual/perceptual features of an object (conceptual task). We contrasted the connectivity patterns associated with a functionally defined region in the parahippocampal cortex (PHC) and anatomically defined anterior and posterior hippocampal segments across these tasks. Examining PHC connectivity patterns revealed that the PHC seed was distinctly connected to other MTL structures during the autobiographical task, to posterior parietal regions during the spatial task and to a distributed network of regions for the conceptual task. Examining hippocampal connectivity patterns revealed that the anterior hippocampus was preferentially connected to regions of default mode network during the autobiographical task and to areas implicated in semantic processing for the conceptual task whereas the posterior hippocampus was preferentially connected to medial-posterior regions of the brain during the spatial task. We interpret our findings as evidence that there are MTL-guided networks for forming distinct types of mental representations that align with functional distinctions within the hippocampus.

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Section: Discussionmentioning

confidence: 99%

The medial temporal lobe functional connectivity patterns associated with forming different mental representations

Levine

2018

Hippocampus

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“…Using a novel loop closure task in 31 participants, Chrastil et al (2015) found that the hippocampus, RSC, para-hippocampal cortex and medial prefrontal cortex (mPFC) were recruited during successful path integration. Interestingly, in our results, the course of fiber tractography of the CB-II associates with all these brain regions, suggests a potential role of the CB-II in supporting path integration.…”

Section: Discussionmentioning

confidence: 99%

Segmentation of the Cingulum Bundle in the Human Brain: A New Perspective Based on DSI Tractography and Fiber Dissection Study

et al. 2016

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The cingulum bundle (CB) is a critical white matter fiber tract in the brain, which forms connections between the frontal lobe, parietal lobe and temporal lobe. In non-human primates, the CB is actually divided into distinct subcomponents on the basis of corticocortical connections. However, at present, no study has verified similar distinct subdivisions in the human brain. In this study, we reconstructed these distinct subdivisions in the human brain, and determined their exact cortical connections using high definition fiber tracking (HDFT) technique on 10 healthy adults and a 488-subject template from the Human Connectome Project (HCP-488). Fiber dissections were performed to verify tractography results. Five CB segments were identified. CB-I ran from the subrostral areas to the precuneus and splenium, encircling the corpus callosum (CC). CB-II arched around the splenium and extended anteriorly above the CC to the medial aspect of the superior frontal gyrus (SFG). CB-III connected the superior parietal lobule (SPL) and precuneus with the medial aspect of the SFG. CB-IV was a relatively minor subcomponent from the SPL and precuneus to the frontal region. CB-V, the para-hippocampal cingulum, stemmed from the medial temporal lobe and fanned out to the occipital lobes. Our findings not only provide a more accurate and detailed description on the associated architecture of the subcomponents within the CB, but also offer new insights into the functional role of the CB in the human brain.

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“…Modeling also demonstrates how coding of spatial location and time can form a framework to form the associations necessary to link events to the spatiotemporal trajectory of an episodic memory [56,82]. Modeling of episodic memories as trajectories has inspired experimental tests of the coding of memory in humans [1–3,69,73]. However, a full understanding of the network dynamics for coding space and time in episodic memory will require both more sophisticated and detailed models as well as more explicit experimental tests of the different mechanistic components of these computational models.…”

Section: Resultsmentioning

confidence: 99%

“…Subsequent work showed that retrieval of a planned trajectory involves reactivation of intermediate locations on the trajectory [2]. Studies show coding of navigationally relevant information in fMRI activity, with hippocampus coding path length and entorhinal cortex coding the Euclidean distance to the goal [3,73]. Modeling shows how interaction of brain regions can allow performance based on semantic memory for the allocentric position of landmarks translated to the egocentric position of landmarks [45].…”

Section: Modeling Of Spatial Memory (Grid Cells Place Cells and Splimentioning

confidence: 99%

“…Modeling shows how interaction of brain regions can allow performance based on semantic memory for the allocentric position of landmarks translated to the egocentric position of landmarks [45]. These models and other work on the influence of visual cues [47] are relevant to data showing the interaction of regions coding visual cues such as optic flow and feature angle with regions involved in navigation [73,74]. …”

Section: Modeling Of Spatial Memory (Grid Cells Place Cells and Splimentioning

confidence: 99%

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Models of spatial and temporal dimensions of memory

Hasselmo

Hinman

Dannenberg

et al. 2017

Current Opinion in Behavioral Sciences

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Episodic memory involves coding of the spatial location and time of individual events. Coding of space and time is also relevant to working memory, spatial navigation, and the disambiguation of overlapping memory representations. Neurophysiological data demonstrate that neuronal activity codes the current, past and future location of an animal as well as temporal intervals within a task. Models have addressed how neural coding of space and time for memory function could arise, with both dimensions coded by the same neurons. Neural coding could depend upon network oscillatory and attractor dynamics as well as modulation of neuronal intrinsic properties. These models are relevant to the coding of space and time involving structures including the hippocampus, entorhinal cortex, retrosplenial cortex, striatum and parahippocampal gyrus, which have been implicated in both animal and human studies.

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There and Back Again: Hippocampus and Retrosplenial Cortex Track Homing Distance during Human Path Integration

Cited by 112 publications

References 74 publications

The medial temporal lobe functional connectivity patterns associated with forming different mental representations

The medial temporal lobe functional connectivity patterns associated with forming different mental representations

Segmentation of the Cingulum Bundle in the Human Brain: A New Perspective Based on DSI Tractography and Fiber Dissection Study

Models of spatial and temporal dimensions of memory

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