There is no more wound complications with transabdominal open abdominal aortic aneurysm repair compared with the retroperitoneal approach

Schiava, Nellie Della; Lermusiaux, Patrick

doi:10.1016/j.jvs.2020.09.045

Cited by 2 publications

(1 citation statement)

References 8 publications

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“…In addition to midline abdominal incision to expose AAA, some chirurgeons make incisions outside the peritoneum from the left side, but whether the latter would reduce the incidence of postoperative intestinal obstruction, pulmonary complications, cardiovascular complications and fluid transfer needs further research. 286 Moreover, because patients with aneurysm are at high risk of cardiovascular disease, the cardiac function of patients should be evaluated before surgery. Some studies have found that the perioperative mortality of AAA surgery is significantly related to the preoperative cardiac function of patients.…”

Section: Clinical Cohort Studymentioning

confidence: 99%

The mechanism and therapy of aortic aneurysms

Gao

Cao

et al. 2023

Sig Transduct Target Ther

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Aortic aneurysm is a chronic aortic disease affected by many factors. Although it is generally asymptomatic, it poses a significant threat to human life due to a high risk of rupture. Because of its strong concealment, it is difficult to diagnose the disease in the early stage. At present, there are no effective drugs for the treatment of aneurysms. Surgical intervention and endovascular treatment are the only therapies. Although current studies have discovered that inflammatory responses as well as the production and activation of various proteases promote aortic aneurysm, the specific mechanisms remain unclear. Researchers are further exploring the pathogenesis of aneurysms to find new targets for diagnosis and treatment. To better understand aortic aneurysm, this review elaborates on the discovery history of aortic aneurysm, main classification and clinical manifestations, related molecular mechanisms, clinical cohort studies and animal models, with the ultimate goal of providing insights into the treatment of this devastating disease. The underlying problem with aneurysm disease is weakening of the aortic wall, leading to progressive dilation. If not treated in time, the aortic aneurysm eventually ruptures. An aortic aneurysm is a local enlargement of an artery caused by a weakening of the aortic wall. The disease is usually asymptomatic but leads to high mortality due to the risk of artery rupture.

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Section: Clinical Cohort Studymentioning

confidence: 99%

The mechanism and therapy of aortic aneurysms

Gao

Cao

et al. 2023

Sig Transduct Target Ther

View full text Add to dashboard Cite

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Causal Effect of Multi-cohort Circulating Proteome on the Risk of Aortic Aneurysm: A Mendelian Randomization Study

Zheng,

Qin,

et al. 2024

Preprint

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BackgroundThe pathogenesis of aortic aneurysm (AA) remains unclear, and there are no effective therapeutic drugs or targets. Circulating plasma proteins are considered biomarkers of AA and potential therapeutic targets for AA. This study aimed to systematically evaluate the causal effects of plasma proteins on AA using a multi-cohort Mendelian randomization (MR) approach.MethodsProtein quantitative trait loci (pQTLs) was obtained from 9 published proteome genome-wide association studies (GWAS) and AA GWAS data from the FinnGen cohort. Independent pQTLs were selected as instrumental variables (IVs). Two-sample MR analysis was performed using inverse-variance weighted, MR-Egger regression, weighted median, weighted mode, and simple mode methods. Heterogeneity and pleiotropy were assessed using Cochran’s Q test, I² statistic, MR-Egger intercept, MR-PRESSO, and Leave-one-out analysis. Steiger filtering was used to test the causal direction. Colocalization analysis and pQTL-eQTL overlap assessment were conducted to validate the findings. Pathway enrichment and drug target analyses were performed to explore the biological and clinical implications of the MR results.ResultsA total of 8,285 pQTLs for 4,421 proteins were retained as IVs. Using cis-pQTLs for IVs, MR analysis identified 154 proteins causally associated with TAA (76 protective factors and 78 risk factors) and 211 proteins with AAA (112 protective factors and 99 risk factors). Using cis-pQTLs+trans-pQTLs for IVs, MR analysis identified 236 proteins causally associated with TAA (113 protective factors and 123 risk factors) and 309 proteins with AAA (143 protective factors and 166 risk factors). The MR results showed no significant heterogeneity or pleiotropy. Steiger filtering confirmed the causal direction from circulating proteins to AA. Colocalization analysis found evidence of shared causal variants between multiple proteins and AA. The majority of AA-associated proteins had pQTLs overlapping with blood eQTLs or proxy eQTLs. Pathway enrichment analysis revealed that these proteins were involved in stress response, immune regulation, cytokine-cytokine receptor interaction, metabolic processes and so on. Nearly two-thirds of the causally related proteins were classified as druggable or potentially druggable targets.ConclusionsThis study identified a large number of potentially novel pathogenic proteins and therapeutic targets for AA, providing important references for elucidating the molecular pathogenesis of AA and advancing drug development.

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There is no more wound complications with transabdominal open abdominal aortic aneurysm repair compared with the retroperitoneal approach

Cited by 2 publications

References 8 publications

The mechanism and therapy of aortic aneurysms

The mechanism and therapy of aortic aneurysms

Causal Effect of Multi-cohort Circulating Proteome on the Risk of Aortic Aneurysm: A Mendelian Randomization Study

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